COX-2 selective inhibitors cardiac toxicity: getting to the heart of the matter [0.03%]
选择性环氧合酶-2抑制剂的心脏毒性：问题核心所在
Neal M Davies,Fakhreddin Jamali
Neal M Davies
On September 30, 2004, Merck and Co. voluntary withdrew rofecoxib (Vioxx) from the market due to increased risk of cardiovascular events associated with the drug. This raised some issues. It is unclear whether the cardiac toxicities associa...
In vitro studies on guar gum based formulation for the colon targeted delivery of Sennosides [0.03%]
基于瓜尔胶的塞诺苷结肠定位给药制剂的体外研究
Munira Momin,K Pundarikakshudu
Munira Momin
Purpose: The objective of the present study is to develop colon targeted drug delivery systems for sennosides using guar gum as a carrier. Methods: ...
Artificial cell microcapsule for oral delivery of live bacterial cells for therapy: design, preparation, and in-vitro characterization [0.03%]
口服递送治疗用活细菌细胞的仿生微胶囊的设计、制备及体外评价研究
Wei Ouyang,Hongmei Chen,Mitchell L Jones et al.
Wei Ouyang et al.
Purpose: Bacterial cells can be engineered to synthesize a wide array of disease modifying substrates such as cytokines, vaccines and antibodies; however, their use as an orally delivered therapeutic is limited by poor ga...
Alteration of rat hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities by Satureja khuzestanica Jamzad essential oil [0.03%]
Satureja khuzestanica Jamzad精油对大鼠肝脏糖原磷酸化酶和丙酮酸羧化酶活性的影响
Maryan Saadat,Shirin Pournourmohammadi,Mohadeseh Donyavi et al.
Maryan Saadat et al.
Purpose: Regarding reported antidiabetic effect of Satureja khuzestanica essential oil (SKEO) and important role of liver on body glucose metabolism by glycogenolysis and gluconeogenesis, we were interested to examine eff...
High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms [0.03%]
高效液相色谱法测定银杏固体制剂中选氟烷醇的含量
Mary-Jean Dubber,Isadore Kanfer
Mary-Jean Dubber
Purpose: This paper describes a validated high-performance liquid chromatographic (HPLC) - photodiode array (PDA) detection method to quantitate five flavonol components as markers; rutin, quercitrin, quercetin, kaempfero...
Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress [0.03%]
姜黄素及其类似物对抗酒精和不饱和脂肪酸诱导的氧化应激的比较研究
Rajagopalan Rukkumani,Kode Aruna,Penumathsa Suresh Varma et al.
Rajagopalan Rukkumani et al.
Purpose: Alcoholic liver disease is a major medical complication of alcohol abuse and a common liver disease in western countries. Increasing evidence demonstrates that oxidative stress plays an important etiologic role i...
In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4 [0.03%]
缬草根商业提取物的人体细胞色素P450 3A4的在内的活性
Tania Lefebvre,Brian C Foster,Cathy E Drouin et al.
Tania Lefebvre et al.
Purpose: Valerian root ( Valeriana officinalis L.) has been used since antiquity as a medicinal herb. Recent studies have found that certain herbal products used concomitantly with conventional therapeutic products can ma...
Synthesis of 4-aryl substituted semicarbazones of some terpenes as novel anticonvulsants [0.03%]
合成某些萜类化合物的4-芳基半卡巴唑
Navneet Aggarwal,Pradeep Mishra
Navneet Aggarwal
Purpose: A series of 4-aryl substituted semicarbazones of citral and R- (-) carvone were designed and synthesized to meet the structural requirements essential for anticonvulsant activity. ...
Tamoxifen in topical liposomes: development, characterization and in-vitro evaluation [0.03%]
他莫西芬载脂质体及其体外实验研究与发展表征工作研究报告摘要
Amit Bhatia,Rajiv Kumar,Om Prakash Katare
Amit Bhatia
Purpose: Tamoxifen, an anti-estrogen compound, has recently been figured as a useful agent in the treatment of certain skin specific disorders. This recent found application has generated an interest in its topical formul...
Multicomposite ultrathin capsules for sustained ocular delivery of ciprofloxacin hydrochloride [0.03%]
用于盐酸环丙沙星眼用缓释给药的多组分超薄囊壳
Dipankar Bhadra,Girish Gupta,Sulekha Bhadra et al.
Dipankar Bhadra et al.
Purpose: The present work is intended to develop a sustained bioadhesive drug delivery system for delivery of Ciprofloxacin Hydrochloride in Cul-de-Sac for sustained and effective antimicrobial chemotherapy. For this, ult...