Evaluating gelatin based nanoparticles as a carrier system for double stranded oligonucleotides [0.03%]
基于明胶的纳米颗粒作为双链寡核苷酸载体系统的评价研究
Jan Zillies,Conrad Coester
Jan Zillies
Purpose: Surface modified gelatin nanoparticles were tested as a potential carrier system for double stranded DNA and RNA oligonucleotides. The results will be discussed with regard to former experiments conducted with si...
Molecular zipper assays: a simple homosandwich with the sensitivity of PCR [0.03%]
分子拉链检测法：具有PCR灵敏度的简单同三聚体检测方法
Sujatha Guttikonda,Welson Wang,Mavanur Suresh
Sujatha Guttikonda
Purpose: The purpose of this study is to develop a simple and inexpensive method for detection of viral load or antigens present in the body fluids as for diagnosis or monitoring of infectious diseases. For example, in ca...
Spectroscopic investigation of the aggregation state of amphotericin B during loading, freeze-drying, and reconstitution of polymeric micelles [0.03%]
聚丙烯酸micelles载两性霉素B的冻干前后两性霉素B聚集态的光谱学研究
Monica Adams,Glen S Kwon
Monica Adams
Purpose: To investigate the relative aggregation state of amphotericin B (AmB) during loading and reconstitution of polymeric micelles. Methods: ...
Effect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide [0.03%]
利用超临界二氧化碳考察酸性三元复合物对克霉唑/ cyclodextrin 包合物形成的影响
Valéry Barillaro,Pascal Bertholet,Sandrine Henry de Hassonville et al.
Valéry Barillaro et al.
Purpose: The aim of the study is to evaluate the effect of different acidic compounds on the inclusion of miconazole (MICO) in several cyclodextrins (CDs) using supercritical carbon dioxide (SCCO(2) ) processing. ...
Angiographic patency study of an albumin-free recombinant streptokinase formulation in acute myocardial infarction [0.03%]
无人血白蛋白重组链激酶新制剂治疗急性心肌梗死的血管通畅度研究
Lorenzo D Llerena,Juan J Quirós,Benito Sainz et al.
Lorenzo D Llerena et al.
Purpose: Fibrinolytic therapy restores coronary patency and reduces mortality in patients with acute myocardial infarction. Albumin is present in most of the streptokinase formulation as a stabilizer but it is not known w...
Influence of the pro-inflammatory cytokines on P-glycoprotein expression and functionality [0.03%]
促炎细胞因子对P-糖蛋白表达及功能的影响研究进展
Christine Fernandez,Marion Buyse,Michèle German-Fattal et al.
Christine Fernandez et al.
Purpose: P-glycoprotein (P-gp) is involved in the transport of many drugs at different barriers with consequence in terms of drug distribution and elimination. The expression and activity of P-gp can be modulated by diffe...
Isoforms of serum gamma-glutamyltransferase in epileptic patients treated with enzyme-inducing anticonvulsant drugs [0.03%]
酶诱导抗惊厥药治疗的癫痫患者血清谷氨酰转移酶同工酶的研究
María Tutor-Crespo,Jesús Hermida,Carlos Tutor
María Tutor-Crespo
Purpose: The increase of serum activity of gamma-glutamyltranferase (gammaGT) through the action of enzyme-inducing anticonvulsant drugs has been widely documented; however, the behaviour of its multiple forms and its rel...
Unaffordable drug prices: the major cause of non-compliance with hypertension medication in Ghana [0.03%]
高血压药物依从性差的主要原因是药品价格过高——以冈比亚为例
Kwame Ohene Buabeng,Lloyd Matowe,Jacob Plange-Rhule
Kwame Ohene Buabeng
Purpose: The prevalence of hypertension is increasing in Ghana. In addition hypertension has been identified as the most common cause of heart failure, stroke, chronic renal disease and spontaneous sudden deaths in Ghana....
A pilot study to evaluate the pharmacokinetics of sibutramine in healthy subjects under fasting and fed conditions [0.03%]
塞洛特林在健康受试者空腹及餐后条件下的药代动力学研究的探索性试验
Zohreh Abolfathi,Jean Couture,François Vallée et al.
Zohreh Abolfathi et al.
Purpose: The purpose of this study was to characterize the food effect on the pharmacokinetics of sibutramine and its pharmacologically active metabolites. ...
Formulation of sustained - release lithium carbonate matrix tablets: influence of hydrophilic materials on the release rate and in vitro-in vivo evaluation [0.03%]
缓释碳酸锂矩阵片剂的制备：亲水性辅料对释放速率的影响及体内外相关性评价
Jaber Emami,Naser Tavakoli,Ahmad Movahedian
Jaber Emami
Purpose: Conventional lithium carbonate (LC) tablets not only produce rapid and relatively high peak blood levels resulting in adverse effects but also should be administered 3 to 4 times daily. These drawbacks can be ove...