Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum [0.03%]
几种巴西药用植物在离体 Guinea pig 回肠和平滑肌条的解痉活性评价
Fernanda Emendörfer,Fabiane Emendörfer,Fernanda Bellato et al.
Fernanda Emendörfer et al.
Purpose: The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants. M...
Transbuccal delivery of lamotrigine across porcine buccal mucosa: in vitro determination of routes of buccal transport [0.03%]
拉莫三嗪经猪颊粘膜传递的颊道传输途径的体外测定研究
Rajashree Mashru,Vijay Sutariya,Mayur Sankalia et al.
Rajashree Mashru et al.
Purpose: To determine the major routes of buccal transport of lamotrigine and to examine the effects of pH on drug permeation. Methods: ...
Steady-state bioequivalence study of clozapine tablet in schizophrenic patients [0.03%]
精神分裂症患者稳态生物等效性研究clozapinetablet
Wongwiwat Tassaneeyakul,Khanogwan Kittiwattanagul,Suda Vannaprasaht et al.
Wongwiwat Tassaneeyakul et al.
Purpose: To compare the bioavailability of two clozapine formulations (100 mg Clozaril tablet from Novartis Pharmaceuticals UK Ltd., UK, as a Reference formulation and 100 mg Cloril tablet from Atlantic Laboratories Corp....
Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals [0.03%]
Asparagus racemosus野生根提取物的止泻潜力实验研究
N Venkatesan,Vadivu Thiyagarajan,Sathiya Narayanan et al.
N Venkatesan et al.
Purpose: Asparagus racemosus Wild root has been used traditionally in Ayurveda for the treatment of diarrhoea and dysentery. However, the claims of Ayurveda need to be validated by a suitable experimental model. Therefore...
Formulation development, in vitro and in vivo evaluation of membrane controlled transdermal systems of glibenclamide [0.03%]
格列本脲膜控释经皮给药系统的处方设计、体内外评价研究
Srinivas Mutalik,Nayanabhirama Udupa
Srinivas Mutalik
Purpose: The objective of the present study was to develop the membrane controlled transdermal systems of glibenclamide and to evaluate with respect o various in vitro and in vivo parameters. ...
The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts [0.03%]
载体类型和浓度对难溶性药物(吲哚美辛)从液固密实剂中溶解速率的影响研究
Ali Nokhodchi,Yousef Javadzadeh,Mohammad Reza Siahi-Shadbad et al.
Ali Nokhodchi et al.
Purpose: For poorly soluble, highly permeable (Class II) drugs, such as indomethacin, the rate of oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Therefore together with the perm...
Sodium citrate cross-linked chitosan films: optimization as substitute for human/rat/rabbit epidermal sheets [0.03%]
用于替代人/大鼠/兔表皮片的壳聚糖薄膜的抗坏血酸优化研究
Vikas Rana,Kumar Babita,Dinesh Goyal et al.
Vikas Rana et al.
PURPOSE. To prepare chitosan films that shall be capable of simulating in vitro permeation of polar (5-FU) and non polar (indomethacin) drugs across rat/rabbit/human epidermis. ...
Evaluation of the first-pass glucuronidation of selected flavones in gut by Caco-2 monolayer model [0.03%]
人Caco-2单层细胞模型评价肠道首过代谢中葡萄糖醛酸结合反应对选择性黄酮的转化作用
Siu Pong Ng,Ka Yin Wong,Li Zhang et al.
Siu Pong Ng et al.
Purpose: Four flavones, namely Apigenin, Baicalein, Chrysin and Luteolin, were selected for study and comparison of their absorption and metabolism in gut using the in vitro Caco-2 monolayer model. ...
Preliminary results of nanopharmaceuticals used in the radioimmunotherapy of ovarian cancer [0.03%]
纳米药物用于卵巢癌放射免疫治疗的初步结果
Steve McQuarrie,John Mercer,Alasdair Syme et al.
Steve McQuarrie et al.
Purpose: The treatment of late stage ovarian cancer presents an unmet clinical need for women around the world. A multistep radioimmunotherapeutic (RIT) approach, exploiting the combination of a bispecific monoclonal anti...
Klaus Zwiorek,Julia Kloeckner,Ernst Wagner et al.
Klaus Zwiorek et al.
Purpose: The aim of this study was to evaluate cationized gelatin nanoparticles as biodegradable and low cell toxic alternative carrier to existing DNA delivery systems. ...