Remdesivir-induced conduction abnormalities: A molecular model-based explanation [0.03%]
瑞德西韦引起的心脏传导异常：基于分子模型的解释
Ryan Kingsley,Christopher Rohlman,Ashley Otto et al.
Ryan Kingsley et al.
Purpose: Remdesivir use in COVID-19 is associated with cardiac conduction abnormalities from unclear mechanisms. A proposed mechanism is the bioaccumulation of the intermediate metabolite GS-441524 resulting in exogenous activation of cardi...
Drug-disease interaction: Clinical consequences of inflammation on drugs action and disposition [0.03%]
药物-疾病相互作用：炎症对药效和代谢的影响
Yasmeen El Hajj Abdallah,Sukhman Chahal,Fakhreddin Jamali et al.
Yasmeen El Hajj Abdallah et al.
Inflammation is a culprit in many conditions affecting millions of people worldwide. A plethora of studies has revealed that inflammation and inflammatory mediators such as cytokines and chemokines are associated with altered expression and...
Persistence and switching patterns of migraine prophylactic medications in Canada: A retrospective claims analysis comparing adherence and evaluating the economic burden of illness [0.03%]
加拿大偏头痛预防药物的用药持续性和换药模式：一项回顾性保险索赔分析，比较依从性并评估疾病经济负担
Andrew Ojo,Steven Zhang,Nataly Bleibdrey et al.
Andrew Ojo et al.
Purpose: To describe patient characteristics, treatment patterns, and the burden of illness among adult migraine patients in Canada prescribed migraine prophylactics. Little is known about the relative persistence of trea...
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea [0.03%]
阿戈美拉汀对阻塞性睡眠呼吸暂停患者的多导睡眠图参数的影响评估
Farzaneh Dastan,Behnaz Gholizadeh Niari,Parisa Adimi Naghan et al.
Farzaneh Dastan et al.
Purpose: Obstructive sleep apnea (OSA) is a common serious sleep disorder. Melatonin-based drugs such as agomelatine may have beneficial effects on patients with sleep disorders. This study aimed to evaluate agomelatine e...
Post-Marketing Safety of Vemurafenib: A Real-World Pharmacovigilance Study of the FDA Adverse Event Reporting System [0.03%]
Vemurafenib上市后安全性的研究：来自FDA不良事件报告系统的实际药物警戒研究
Yanxin Liu,Changjiang Dong,Xucheng He et al.
Yanxin Liu et al.
Purpose: Vemurafenib received approval for treatment of BRAF V600 variation metastatic melanoma in August 2011. This study analyzed Vemurafenib-related adverse events (AEs) to detect and characterize relevant safety signa...
Applications of Exhaled Breath Condensate Analysis for Drug Monitoring and Bioequivalence Study of Inhaled Drugs [0.03%]
呼吸冷凝液分析在吸入药物体内药物监测与生物等效性研究中的应用
Nastaran Hashemzadeh,Elaheh Rahimpour,Abolghasem Jouyban
Nastaran Hashemzadeh
The exhaled breath condensate (EBC) presents a simple and non-invasive alternative approach for bioequivalence assessments and therapeutic drug monitoring of inhaled drugs. EBC better represents the drug at the site of action and eliminates...
Analysis of Prednisolone-Induced Osteoporosis Using the Japanese Adverse Drug Event Report Database [0.03%]
使用日本药物不良事件报告数据库分析泼尼松龙引起的骨质疏松症
Wataru Wakabayashi,Mizuki Tanaka,Kiyoka Matsumoto et al.
Wataru Wakabayashi et al.
Purpose: Osteoporosis is an adverse event of prednisolone. This study aimed to assess prednisolone-induced osteoporosis (PIO) profiles and patient backgrounds by analyzing data from the Japanese Adverse Drug Event Report ...
A Review of Electronic Cigarettes and Liquid Nicotine Poisoning Exposure Cases in the United States [0.03%]
美国电子烟和液态尼古丁中毒曝光案例综述
Ayesha Ahmed
Ayesha Ahmed
Purpose: In 2007, electronic cigarettes (e-cigarette) were introduced as a smoking cessation device. Since then, its sale and marketing has been expanded annually. Concomitantly, there is an increase in the electronic cig...
Review of Pharmaceutical Applications of Diethylene Glycol Monoethyl Ether [0.03%]
二乙烯基乙醚在制药领域中的应用综述
Nastaran Hashemzadeh,Abolghasem Jouyban
Nastaran Hashemzadeh
Diethylene glycol monoethyl ether (DEGME) is a hydroalcoholic solvent that gained tremendous attention in the cosmetics, food, nanoformulations, and pharmaceutical industries. Due to its physicochemical features, it has been widely used as ...
A Survey of the Criteria Used for the Selection of Alternative Comparator Products by Participating Regulators and Organizations of the International Pharmaceutical Regulators Programme [0.03%]
国际药品监管项目参议组织选用对照药的评定标准调查研究报告
Andrew Tam,Alfredo Garcia-Arieta,Ivana Abalos et al.
Andrew Tam et al.
The safety and efficacy of a generic product are partly based on demonstrating bioequivalence to the innovator product; however, when the innovator product is no longer available as a comparator product, a survey conducted within the Bioequ...