Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study [0.03%]
右美托咪啶鼻喷剂用于颌面手术后首夜睡眠障碍的临床观察：单中心双盲随机对照试验
Ye Wang,Zibin Jin,Wenli Xu et al.
Ye Wang et al.
Purpose: Dexmedetomidine exerts a sedative effect by promoting the sleep pathway endogenously and producing a state similar to N2 sleep. This study aimed to study the efficacy and safety of dexmedetomidine nasal spray in the treatment of po...
Integration of real-world evidence from different data sources in health technology assessment [0.03%]
基于不同数据来源的真实世界证据在卫生技术评估中的整合
Pooyeh Graili,Jason R Guertin,Kelvin K W Chan et al.
Pooyeh Graili et al.
Real-world evidence (RWE) is being increasingly used by a wide range of stakeholders involved in the therapeutic product lifecycle but remains underutilized in the health technology assessment (HTA) process. RWE aims to fill the current evi...
COVID-19 mRNA vaccination is associated with IgA nephropathy: an analysis of the Japanese adverse drug event report database [0.03%]
新冠mRNA疫苗接种与IgA肾病相关性分析：基于日本药品不良事件报告数据库的一项研究
Hiroka Nakao,Takenao Koseki,Koki Kato et al.
Hiroka Nakao et al.
Purpose: Coronavirus disease 2019 (COVID-19) mRNA vaccines are used worldwide to prevent severe symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. IgA nephropathy (IgAN) is the most common form of glomerular...
Network pharmacology and molecular docking reveal the immunomodulatory mechanism of rhubarb peony decoction for the treatment of ulcerative colitis and irritable bowel syndrome [0.03%]
网络药理学和分子对接揭示了大黄牡丹汤治疗溃疡性结肠炎和肠易激综合症的免疫调节机制
Leilei Zhai,Weiming Yang,Dianrong Li et al.
Leilei Zhai et al.
Background: Ulcerative colitis (UC) and irritable bowel syndrome (IBS) share various similarities in clinical symptoms, pathogenesis, and treatment. UC concurrent IBS tends toward more severe symptoms and worse prognosis, and promising feas...
A new method for investigating bioequivalence of inhaled formulations: A pilot study on salbutamol [0.03%]
一种新的吸入制剂生物等效性研究方法：一项关于沙丁胺醇的试点研究
Homa Rezaei,Maryam Khoubnasabjafari,Vahid Jouyban-Gharamaleki et al.
Homa Rezaei et al.
Purpose: An efficient, cost-effective and non-invasive test is required to overcome the challenges faced in the process of bioequivalence (BE) studies of various orally inhaled drug formulations. Two different types of pressurized meter dos...
Occurrence of intraocular hemorrhages under monotherapy or combination therapy of antiplatelets and anticoagulants using the Japanese Adverse Drug Event Report database [0.03%]
基于日本药品不良反应报告数据库的抗血小板药和抗凝药单独或联合治疗的眼内出血事件分析
Junko Tanaka,Takenao Koseki,Kohsuke Sekido et al.
Junko Tanaka et al.
Purpose: An intraocular hemorrhage is an adverse event that can lead to visual acuity impairment. Antithrombotic therapy with antiplatelet agents and anticoagulants may increase intraocular hemorrhage. However, since their frequency is low,...
Adapting artificial intelligence into the evolution of pharmaceutical sciences and publishing: Technological darwinism [0.03%]
人工智能在药学科学和出版业发展中的应用：技术达尔文主义
Neal M Davies
Neal M Davies
Grading pharmacists' risk of complaints to a regulator: A retrospective cohort study [0.03%]
药剂师向监管机构投诉风险的分级：一项回顾性队列研究
Katherine Morris,Matthew J Spittal
Katherine Morris
Background: Tools to grade risk of complaint to a regulatory board have been developed for physicians but not for other health practitioner groups, including pharmacists. We aimed to develop a score that classified pharmacists into low, med...
Shared decision-making practices and patient values in pharmacist outpatient care for rheumatic disease: A multiple correspondence analysis [0.03%]
风湿病药学门诊的共同决策实践与患者价值观：多重对应分析法研究
Ikkou Hirata,Shunsuke Hanaoka,Ryo Rokutanda et al.
Ikkou Hirata et al.
Purpose: To investigate the value-to-value relationships, relationship between values and patient background, continuation rate of treatment after shared decision-making (SDM), and disease status in order to clarify the values involved in d...
The role of CYP2C9*2, CYP2C9*3 and VKORC1- 1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study [0.03%]
CYP2C9*2、CYP2C9*3和VKORC1-1639基因多态性与消化性出血的相关性研究：全病例对照研究
Marcela Forgerini,Gustavo Urbano,Tales Rubens De Nadai et al.
Marcela Forgerini et al.
Purpose: To investigate whether interindividual variability in the CYP2C9 (*2 and *3 alleles) and VKORC1 (rs9923231) genes is associated with increased risk of upper gastrointestinal bleeding (UGIB) in users of non-steroidal anti-inflammato...