Investigating the effect of prescribing status and patient characteristics on the therapeutic outcomes in patients with diabetes using a leftover drug adjustment protocol [0.03%]
探究处方状况和患者特征对糖尿病剩余药物调整方案治疗效果的影响
Toshiyuki Hirai,Shunsuke Hanaoka,Yuusuke Terakado et al.
Toshiyuki Hirai et al.
Treatment for diabetes includes anti-diabetic medication in addition to lifestyle improvements through diet and exercise. In Japan, protocol-based pharmacotherapy management allows drug treatment to be provided through cooperation between p...
Obesity management for the treatment of type 2 diabetes: emerging evidence and therapeutic approaches [0.03%]
肥胖管理在2型糖尿病的治疗中的新兴证据及治疗策略
Arianne Morissette,Erin E Mulvihill
Arianne Morissette
Excess adiposity can contribute to metabolic complications, such as type 2 diabetes mellitus (T2DM), which poses a significant global health burden. Traditionally viewed as a chronic and irreversible condition, T2DM management has evolved a...
Genetics, pharmacotherapy, and dietary interventions in childhood obesity [0.03%]
儿童肥胖的遗传学、药物治疗和饮食干预措施
Joe Eun Son
Joe Eun Son
Childhood obesity has emerged as a major global health issue, contributing to the increased prevalence of chronic conditions and adversely affecting the quality of life and future prospects of affected individuals, thereby presenting a subs...
Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy [0.03%]
肥胖和糖尿病心肌病中脂毒性的治疗靶点作用机制研究
Michinari Nakamura
Michinari Nakamura
Unhealthy sources of fats, ultra-processed foods with added sugars, and a sedentary lifestyle make humans more susceptible to developing overweight and obesity. While lipids constitute an integral component of the organism, excessive and ab...
Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties [0.03%]
泰国芒果种子内胚乳提取物敷料的抗菌性能与纳米结晶银敷料的对比研究
Sukhontha Hasatsri,Bajaree Jantrapanukorn
Sukhontha Hasatsri
Introduction: The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. This suggests tha...
The bioequivalence study design recommendations for immediate-release solid oral dosage forms in the international pharmaceutical regulators programme participating regulators and organisations: differences and commonalities [0.03%]
国际药品监管机构计划参与监管部门和组织针对口服固体制剂仿制药生物等效性研究设计的建议：异同点分析
Eduardo Agostinho Freitas Fernandes,Joy van Oudtshoorn,Andrew Tam et al.
Eduardo Agostinho Freitas Fernandes et al.
Bioequivalence (BE) studies are considered the standard for demonstrating that the performance of a generic drug product in the human body is sufficiently similar to that of its comparator product. The objective of this article is to descri...
Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery [0.03%]
近年来聚合物微针促进长效透皮给药的研究进展
Fanda Meng,Xinyu Qiao,Chenglong Xin et al.
Fanda Meng et al.
Microneedle (MN)-assisted drug delivery technology has gained increasing attention over the past two decades. Its advantages of self-management and being minimally invasive could allow this technology to be an alternative to hypodermic need...
Alistair K C Chan,Nehil Ranjitham Gopalakrishnan,Yannick Leandre Traore et al.
Alistair K C Chan et al.
Additive manufacturing, commonly referred to as three-dimensional (3D) printing, has the potential to initiate a paradigm shift in the field of medicine and drug delivery. Ever since the advent of the first-ever United States Food and Drug ...
Real-world data: a comprehensive literature review on the barriers, challenges, and opportunities associated with their inclusion in the health technology assessment process [0.03%]
真实世界数据：系统回顾在卫生技术评估过程中纳入所面临的障碍、挑战和机遇
Konstantinos Zisis,Elpida Pavi,Mary Geitona et al.
Konstantinos Zisis et al.
Objective: This review aimed to assess the current use and acceptance of real-world data (RWD) and real-world evidence (RWE) in health technology assessment (HTA) process. It additionally aimed to discern stakeholders' viewpoints concerning...
Ali Ghayoor,Hamed Gilzad Kohan
Ali Ghayoor
This editorial explores how artificial intelligence (AI) is revolutionizing the science of pharmacokinetics (PK). It discusses the challenges of conventional PK analysis and how AI has transformed this area. It highlights the promise of art...