Rasim Masimov,Ellen K Wasan
Rasim Masimov
Chitosan is an extensively used polymer for drug delivery applications in particulate and non-particulate carriers. Chitosan-based particulate, nano-, and microparticle, carriers have been the most extensively studied for the delivery of th...
The role of acetylation in obesity-induced cardiac metabolic alterations [0.03%]
乙酰化在肥胖引起的心肌代谢重编程中的作用
Ezra B Ketema,Gary D Lopaschuk
Ezra B Ketema
Obesity is a growing public health problem, with its prevalence rate having tripled in the last five decades. It has been shown that obesity is associated with alterations in cardiac energy metabolism, which in turn plays a significant role...
From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling [0.03%]
从禁食到脂肪重塑：间歇性禁食诱导的脂肪组织重塑的分子途径探究
Nathaniel Vo,Qiwei Zhang,Hoon-Ki Sung
Nathaniel Vo
Obesity, characterised by excessive fat accumulation, is a complex chronic condition that results from dysfunctional adipose tissue expansion due to prolonged calorie surplus. This leads to rapid adipocyte enlargement that exceeds the suppo...
Brinda Prapaharan,Micah Lea,Jacqueline L Beaudry
Brinda Prapaharan
Brown adipose tissue (BAT) activation is an emerging target for obesity treatments due to its thermogenic properties stemming from its ability to shuttle energy through uncoupling protein 1 (Ucp1). Recent rodent studies show how BAT and whi...
Lipoprotein lipase as a target for obesity/diabetes related cardiovascular disease [0.03%]
脂蛋白脂肪酶作为肥胖/糖尿病相关心血管疾病的靶点
Rui Shang,Brian Rodrigues
Rui Shang
Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being their leading cause of death. Traditionally, the management of obesity and diabetes has focused mainly on weight reduction and controlling high blood...
The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance [0.03%]
支链氨基酸及其下游代谢产物介导胰岛素抵抗的作用机制
Abdualrahman Mohammed Abdualkader,Qutuba G Karwi,Gary D Lopaschuk et al.
Abdualrahman Mohammed Abdualkader et al.
Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite extensive research, the precise mechanisms linking increased BCA...
Development and validation of an LC-MS/MS method for ruxolitinib quantification: advancing personalized therapy in hematologic malignancies [0.03%]
芦可替尼定量的LC-MS/MS方法的开发与验证：推进血液系统恶性肿瘤的个性化治疗
Na Li,Huiying Zhang,Haochen Bai et al.
Na Li et al.
Background: Hematologic malignancies such as leukemia and lymphoma present treatment challenges due to their genetic and molecular heterogeneity. Ruxolitinib, a Janus kinase (JAK) inhibitor, has demonstrated efficacy in m...
Angela Wong,Qiuyu Sun,Ismail Ibrahim Latif et al.
Angela Wong et al.
Recent literature extensively investigates the crucial role of energy metabolism in determining the inflammatory response and polarization status of macrophages. This rapidly expanding area of research highlights the importance of understan...
Community pharmacists as antimicrobial resistance stewards: a narrative review on their contributions and challenges in low- and middle-income countries [0.03%]
社区药房从业人员作为抗菌药物管理者的角色：一项关于其在中低收入国家中的贡献与挑战的故事性回顾研究
Rosy Raju,Sunitha Chandrashekar Srinivas,Srikanth Malavalli Siddalingegowda et al.
Rosy Raju et al.
Antimicrobial resistance (AMR) is a global public health crisis that impedes the therapeutic effectiveness of available antimicrobial agents. Due to the high burden of infectious diseases and limited resources, especially trained healthcare...
Real-world community hospital hyperglycemia management in noncritically ill, type 2 diabetic patients: a comparison between basal-bolus insulin and correctional insulin [0.03%]
基础与餐时胰岛素治疗与校正剂量胰岛素治疗非重症2型糖尿病患者的院内高血糖管理效果的比较：一项真实世界社区医院的研究
Caiyun J Yang,Chelsey Bourgeois,Elina Delgado et al.
Caiyun J Yang et al.
Purpose: This study evaluated the safety and efficacy of two insulin regimens for inpatient hyperglycemia management: combination short-plus long-acting insulin (basal-bolus insulin regimen, BBIR) vs. short-acting insulin...