Development and validation of an LC-MS/MS method for ruxolitinib quantification: advancing personalized therapy in hematologic malignancies [0.03%]
芦可替尼定量的LC-MS/MS方法的开发与验证：推进血液系统恶性肿瘤的个性化治疗
Na Li,Huiying Zhang,Haochen Bai et al.
Na Li et al.
Background: Hematologic malignancies such as leukemia and lymphoma present treatment challenges due to their genetic and molecular heterogeneity. Ruxolitinib, a Janus kinase (JAK) inhibitor, has demonstrated efficacy in m...
Angela Wong,Qiuyu Sun,Ismail Ibrahim Latif et al.
Angela Wong et al.
Recent literature extensively investigates the crucial role of energy metabolism in determining the inflammatory response and polarization status of macrophages. This rapidly expanding area of research highlights the importance of understan...
Community pharmacists as antimicrobial resistance stewards: a narrative review on their contributions and challenges in low- and middle-income countries [0.03%]
社区药房从业人员作为抗菌药物管理者的角色：一项关于其在中低收入国家中的贡献与挑战的故事性回顾研究
Rosy Raju,Sunitha Chandrashekar Srinivas,Srikanth Malavalli Siddalingegowda et al.
Rosy Raju et al.
Antimicrobial resistance (AMR) is a global public health crisis that impedes the therapeutic effectiveness of available antimicrobial agents. Due to the high burden of infectious diseases and limited resources, especially trained healthcare...
Real-world community hospital hyperglycemia management in noncritically ill, type 2 diabetic patients: a comparison between basal-bolus insulin and correctional insulin [0.03%]
基础与餐时胰岛素治疗与校正剂量胰岛素治疗非重症2型糖尿病患者的院内高血糖管理效果的比较：一项真实世界社区医院的研究
Caiyun J Yang,Chelsey Bourgeois,Elina Delgado et al.
Caiyun J Yang et al.
Purpose: This study evaluated the safety and efficacy of two insulin regimens for inpatient hyperglycemia management: combination short-plus long-acting insulin (basal-bolus insulin regimen, BBIR) vs. short-acting insulin...
Investigating the effect of prescribing status and patient characteristics on the therapeutic outcomes in patients with diabetes using a leftover drug adjustment protocol [0.03%]
探究处方状况和患者特征对糖尿病剩余药物调整方案治疗效果的影响
Toshiyuki Hirai,Shunsuke Hanaoka,Yuusuke Terakado et al.
Toshiyuki Hirai et al.
Treatment for diabetes includes anti-diabetic medication in addition to lifestyle improvements through diet and exercise. In Japan, protocol-based pharmacotherapy management allows drug treatment to be provided through cooperation between p...
Obesity management for the treatment of type 2 diabetes: emerging evidence and therapeutic approaches [0.03%]
肥胖管理在2型糖尿病的治疗中的新兴证据及治疗策略
Arianne Morissette,Erin E Mulvihill
Arianne Morissette
Excess adiposity can contribute to metabolic complications, such as type 2 diabetes mellitus (T2DM), which poses a significant global health burden. Traditionally viewed as a chronic and irreversible condition, T2DM management has evolved a...
Genetics, pharmacotherapy, and dietary interventions in childhood obesity [0.03%]
儿童肥胖的遗传学、药物治疗和饮食干预措施
Joe Eun Son
Joe Eun Son
Childhood obesity has emerged as a major global health issue, contributing to the increased prevalence of chronic conditions and adversely affecting the quality of life and future prospects of affected individuals, thereby presenting a subs...
Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy [0.03%]
肥胖和糖尿病心肌病中脂毒性的治疗靶点作用机制研究
Michinari Nakamura
Michinari Nakamura
Unhealthy sources of fats, ultra-processed foods with added sugars, and a sedentary lifestyle make humans more susceptible to developing overweight and obesity. While lipids constitute an integral component of the organism, excessive and ab...
Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties [0.03%]
泰国芒果种子内胚乳提取物敷料的抗菌性能与纳米结晶银敷料的对比研究
Sukhontha Hasatsri,Bajaree Jantrapanukorn
Sukhontha Hasatsri
Introduction: The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. This suggests tha...
The bioequivalence study design recommendations for immediate-release solid oral dosage forms in the international pharmaceutical regulators programme participating regulators and organisations: differences and commonalities [0.03%]
国际药品监管机构计划参与监管部门和组织针对口服固体制剂仿制药生物等效性研究设计的建议：异同点分析
Eduardo Agostinho Freitas Fernandes,Joy van Oudtshoorn,Andrew Tam et al.
Eduardo Agostinho Freitas Fernandes et al.
Bioequivalence (BE) studies are considered the standard for demonstrating that the performance of a generic drug product in the human body is sufficiently similar to that of its comparator product. The objective of this article is to descri...