Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy [0.03%]
肥胖和糖尿病心肌病中脂毒性的治疗靶点作用机制研究
Michinari Nakamura
Michinari Nakamura
Unhealthy sources of fats, ultra-processed foods with added sugars, and a sedentary lifestyle make humans more susceptible to developing overweight and obesity. While lipids constitute an integral component of the organism, excessive and ab...
Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties [0.03%]
泰国芒果种子内胚乳提取物敷料的抗菌性能与纳米结晶银敷料的对比研究
Sukhontha Hasatsri,Bajaree Jantrapanukorn
Sukhontha Hasatsri
Introduction: The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. This suggests tha...
The bioequivalence study design recommendations for immediate-release solid oral dosage forms in the international pharmaceutical regulators programme participating regulators and organisations: differences and commonalities [0.03%]
国际药品监管机构计划参与监管部门和组织针对口服固体制剂仿制药生物等效性研究设计的建议：异同点分析
Eduardo Agostinho Freitas Fernandes,Joy van Oudtshoorn,Andrew Tam et al.
Eduardo Agostinho Freitas Fernandes et al.
Bioequivalence (BE) studies are considered the standard for demonstrating that the performance of a generic drug product in the human body is sufficiently similar to that of its comparator product. The objective of this article is to descri...
Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery [0.03%]
近年来聚合物微针促进长效透皮给药的研究进展
Fanda Meng,Xinyu Qiao,Chenglong Xin et al.
Fanda Meng et al.
Microneedle (MN)-assisted drug delivery technology has gained increasing attention over the past two decades. Its advantages of self-management and being minimally invasive could allow this technology to be an alternative to hypodermic need...
Alistair K C Chan,Nehil Ranjitham Gopalakrishnan,Yannick Leandre Traore et al.
Alistair K C Chan et al.
Additive manufacturing, commonly referred to as three-dimensional (3D) printing, has the potential to initiate a paradigm shift in the field of medicine and drug delivery. Ever since the advent of the first-ever United States Food and Drug ...
Real-world data: a comprehensive literature review on the barriers, challenges, and opportunities associated with their inclusion in the health technology assessment process [0.03%]
真实世界数据：系统回顾在卫生技术评估过程中纳入所面临的障碍、挑战和机遇
Konstantinos Zisis,Elpida Pavi,Mary Geitona et al.
Konstantinos Zisis et al.
Objective: This review aimed to assess the current use and acceptance of real-world data (RWD) and real-world evidence (RWE) in health technology assessment (HTA) process. It additionally aimed to discern stakeholders' viewpoints concerning...
Ali Ghayoor,Hamed Gilzad Kohan
Ali Ghayoor
This editorial explores how artificial intelligence (AI) is revolutionizing the science of pharmacokinetics (PK). It discusses the challenges of conventional PK analysis and how AI has transformed this area. It highlights the promise of art...
What a pain in the … back: a review of current treatment options with a focus on naproxen sodium [0.03%]
什么痛苦在…背部：当前治疗选择综述并重点关注钠盐naproxen的治疗
Steven M Weisman,Giovanni Ciavarra,Grant Cooper
Steven M Weisman
Non-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological appr...
Catherine Y Lau
Catherine Y Lau
Effect of Oregon grape root extracts on P-glycoprotein mediated transport in in vitro cell lines [0.03%]
小檗根提取物对体外细胞模型中P-糖蛋白介导的转运的影响
Ying Fan,Zhu Zhou,Lei Zhang
Ying Fan
Purpose: This study aims to investigate the potential of Oregon grape root extracts to modulate the activity of P-glycoprotein. Methods: We performed 3H-CsA or 3H-digoxin transport experiments in the absence or presence of two sources of Or...