Brinda Prapaharan,Micah Lea,Jacqueline L Beaudry
Brinda Prapaharan
Brown adipose tissue (BAT) activation is an emerging target for obesity treatments due to its thermogenic properties stemming from its ability to shuttle energy through uncoupling protein 1 (Ucp1). Recent rodent studies show how BAT and whi...
Lipoprotein lipase as a target for obesity/diabetes related cardiovascular disease [0.03%]
脂蛋白脂肪酶作为肥胖/糖尿病相关心血管疾病的靶点
Rui Shang,Brian Rodrigues
Rui Shang
Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being their leading cause of death. Traditionally, the management of obesity and diabetes has focused mainly on weight reduction and controlling high blood...
The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance [0.03%]
支链氨基酸及其下游代谢产物介导胰岛素抵抗的作用机制
Abdualrahman Mohammed Abdualkader,Qutuba G Karwi,Gary D Lopaschuk et al.
Abdualrahman Mohammed Abdualkader et al.
Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite extensive research, the precise mechanisms linking increased BCA...
Development and validation of an LC-MS/MS method for ruxolitinib quantification: advancing personalized therapy in hematologic malignancies [0.03%]
芦可替尼定量的LC-MS/MS方法的开发与验证：推进血液系统恶性肿瘤的个性化治疗
Na Li,Huiying Zhang,Haochen Bai et al.
Na Li et al.
Background: Hematologic malignancies such as leukemia and lymphoma present treatment challenges due to their genetic and molecular heterogeneity. Ruxolitinib, a Janus kinase (JAK) inhibitor, has demonstrated efficacy in m...
Angela Wong,Qiuyu Sun,Ismail Ibrahim Latif et al.
Angela Wong et al.
Recent literature extensively investigates the crucial role of energy metabolism in determining the inflammatory response and polarization status of macrophages. This rapidly expanding area of research highlights the importance of understan...
Community pharmacists as antimicrobial resistance stewards: a narrative review on their contributions and challenges in low- and middle-income countries [0.03%]
社区药房从业人员作为抗菌药物管理者的角色：一项关于其在中低收入国家中的贡献与挑战的故事性回顾研究
Rosy Raju,Sunitha Chandrashekar Srinivas,Srikanth Malavalli Siddalingegowda et al.
Rosy Raju et al.
Antimicrobial resistance (AMR) is a global public health crisis that impedes the therapeutic effectiveness of available antimicrobial agents. Due to the high burden of infectious diseases and limited resources, especially trained healthcare...
Real-world community hospital hyperglycemia management in noncritically ill, type 2 diabetic patients: a comparison between basal-bolus insulin and correctional insulin [0.03%]
基础与餐时胰岛素治疗与校正剂量胰岛素治疗非重症2型糖尿病患者的院内高血糖管理效果的比较：一项真实世界社区医院的研究
Caiyun J Yang,Chelsey Bourgeois,Elina Delgado et al.
Caiyun J Yang et al.
Purpose: This study evaluated the safety and efficacy of two insulin regimens for inpatient hyperglycemia management: combination short-plus long-acting insulin (basal-bolus insulin regimen, BBIR) vs. short-acting insulin...
Investigating the effect of prescribing status and patient characteristics on the therapeutic outcomes in patients with diabetes using a leftover drug adjustment protocol [0.03%]
探究处方状况和患者特征对糖尿病剩余药物调整方案治疗效果的影响
Toshiyuki Hirai,Shunsuke Hanaoka,Yuusuke Terakado et al.
Toshiyuki Hirai et al.
Treatment for diabetes includes anti-diabetic medication in addition to lifestyle improvements through diet and exercise. In Japan, protocol-based pharmacotherapy management allows drug treatment to be provided through cooperation between p...
Obesity management for the treatment of type 2 diabetes: emerging evidence and therapeutic approaches [0.03%]
肥胖管理在2型糖尿病的治疗中的新兴证据及治疗策略
Arianne Morissette,Erin E Mulvihill
Arianne Morissette
Excess adiposity can contribute to metabolic complications, such as type 2 diabetes mellitus (T2DM), which poses a significant global health burden. Traditionally viewed as a chronic and irreversible condition, T2DM management has evolved a...
Genetics, pharmacotherapy, and dietary interventions in childhood obesity [0.03%]
儿童肥胖的遗传学、药物治疗和饮食干预措施
Joe Eun Son
Joe Eun Son
Childhood obesity has emerged as a major global health issue, contributing to the increased prevalence of chronic conditions and adversely affecting the quality of life and future prospects of affected individuals, thereby presenting a subs...