A review on lipid and polymeric nano-based 17-β-estradiol delivery systems: advances and challenges [0.03%]
脂质和聚合物纳米基17-β-雌二醇输送体系的研究进展与挑战综述
Mayara Munhoz de Assis Ramos,Fernanda Yamamoto Ricardo-da-Silva,Luiza de Oliveira Macedo et al.
Mayara Munhoz de Assis Ramos et al.
17β-estradiol (E2) is an endogenous steroid hormone pivotal for the development of female secondary sexual characteristics and the maintenance of the female reproductive system. Its roles extend beyond these physiological functions, as E2 ...
Development of a dry powder formulation for pulmonary delivery of azithromycin-loaded nanoparticles [0.03%]
一种用于肺部给药的红霉素载药纳米颗粒干粉雾化吸入剂的研发
Alison Tatiana Madrid Sani,Khellida Loiane V Ramos-Rocha,Michelle Alvares Sarcinelli et al.
Alison Tatiana Madrid Sani et al.
The COVID-19 pandemic has raised concern regarding respiratory system diseases and oral inhalation stands out as an attractive non-invasive route of administration for pulmonary diseases such as chronic bronchitis, cystic fibrosis, COVID-19...
Sora Kwon,Reshani Jeyaratnam,Kyoung-Han Kim
Sora Kwon
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disorder marked by excessive accumulation of lipids within the liver. If untreated, this condition can progress to metabolic dysfunction-associated steatohepati...
Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study [0.03%]
磺酰脲类药物的药理代谢组学在2型糖尿病患者中的应用：横断面研究
Khaled Naja,Najeha Anwardeen,Sara S Bashraheel et al.
Khaled Naja et al.
Background: Sulfonylureas have been a longstanding pharmacotherapy in the management of type 2 diabetes, with potential benefits beyond glycemic control. Although sulfonylureas are effective, interindividual variability e...
Evaluation of the rational prescription of linezolid, the prevalence of thrombocytopenia and major drug interactions in patients with cardiovascular diseases: are there any cautions? [0.03%]
评价抗葡萄球菌药物利福平的合理用药、血小板减少症的患病率及心血管系统疾病患者的重大药物相互作用：应注意什么？
Mehrnoush Dianatkhah,Hamed Salami,Rasool Soltani et al.
Mehrnoush Dianatkhah et al.
The present study evaluated the rational prescription of linezolid, the prevalence of thrombocytopenia, and major drug interactions in patients with cardiovascular diseases. We conducted a retrospective cross-sectional study on linezolid-tr...
Safety and efficacy of phosphodiesterase-5 (PDE-5) inhibitors in fetal growth restriction: a systematic literature review and meta-analysis [0.03%]
磷酸二酯酶-5抑制剂治疗胎儿生长受限的安全性和有效性的系统综述和meta分析
Ying Liu,Ella Man-Wai Un,Ying Bai et al.
Ying Liu et al.
Introduction: Fetal growth restriction (FGR) is associated with a higher risk of perinatal morbidity and mortality, as well as long-term health issues in newborns. Currently, there is no effective medicine for FGR. Phosphodiesterase-5 (PDE-...
Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy [0.03%]
叉头框O1转录因子；糖尿病心肌病治疗靶点研究进展
Tanin Shafaati,Keshav Gopal
Tanin Shafaati
Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. Th...
Preparation, solubility, and anti-inflammatory effects of a complex of diphenylcyclopropenone/β-cyclodextrin derivatives as the treatment of alopecia areata [0.03%]
茋环丙烯酮/β-环糊精包合物的制备、溶解性及抗炎作用研究及其治疗斑秃的效果
Yutaka Inoue,Kaede Yoshino,Suzu Kudo et al.
Yutaka Inoue et al.
Purpose: To investigate the preparation of inclusion complexes of diphenylcyclopropenone (DPCP)/β-cyclodextrin (β-CD) derivatives using a three-dimensional (3D) ball mill, and verify the inclusion behavior of the solid ...
Development of modular polymeric nanoparticles for drug delivery using amine reactive chemistry [0.03%]
采用胺反应化学用于药物输送的模块化聚合成纳米粒子的发展
Calvin Wong,Emmanuel A Ho
Calvin Wong
Curcumin has been explored for its anti-cancer potential, but is severely limited by its hydrophobicity and sensitivity to light and water. In this study, poly (lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) were synthesized to encapsu...