Safety and efficacy of phosphodiesterase-5 (PDE-5) inhibitors in fetal growth restriction: a systematic literature review and meta-analysis [0.03%]
磷酸二酯酶-5抑制剂治疗胎儿生长受限的安全性和有效性的系统综述和meta分析
Ying Liu,Ella Man-Wai Un,Ying Bai et al.
Ying Liu et al.
Introduction: Fetal growth restriction (FGR) is associated with a higher risk of perinatal morbidity and mortality, as well as long-term health issues in newborns. Currently, there is no effective medicine for FGR. Phosphodiesterase-5 (PDE-...
Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy [0.03%]
叉头框O1转录因子；糖尿病心肌病治疗靶点研究进展
Tanin Shafaati,Keshav Gopal
Tanin Shafaati
Cardiovascular disease including diabetic cardiomyopathy (DbCM) represents the leading cause of death in people with diabetes. DbCM is defined as ventricular dysfunction in the absence of underlying vascular diseases and/or hypertension. Th...
Preparation, solubility, and anti-inflammatory effects of a complex of diphenylcyclopropenone/β-cyclodextrin derivatives as the treatment of alopecia areata [0.03%]
茋环丙烯酮/β-环糊精包合物的制备、溶解性及抗炎作用研究及其治疗斑秃的效果
Yutaka Inoue,Kaede Yoshino,Suzu Kudo et al.
Yutaka Inoue et al.
Purpose: To investigate the preparation of inclusion complexes of diphenylcyclopropenone (DPCP)/β-cyclodextrin (β-CD) derivatives using a three-dimensional (3D) ball mill, and verify the inclusion behavior of the solid ...
Development of modular polymeric nanoparticles for drug delivery using amine reactive chemistry [0.03%]
采用胺反应化学用于药物输送的模块化聚合成纳米粒子的发展
Calvin Wong,Emmanuel A Ho
Calvin Wong
Curcumin has been explored for its anti-cancer potential, but is severely limited by its hydrophobicity and sensitivity to light and water. In this study, poly (lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) were synthesized to encapsu...
Rasim Masimov,Ellen K Wasan
Rasim Masimov
Chitosan is an extensively used polymer for drug delivery applications in particulate and non-particulate carriers. Chitosan-based particulate, nano-, and microparticle, carriers have been the most extensively studied for the delivery of th...
The role of acetylation in obesity-induced cardiac metabolic alterations [0.03%]
乙酰化在肥胖引起的心肌代谢重编程中的作用
Ezra B Ketema,Gary D Lopaschuk
Ezra B Ketema
Obesity is a growing public health problem, with its prevalence rate having tripled in the last five decades. It has been shown that obesity is associated with alterations in cardiac energy metabolism, which in turn plays a significant role...
From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling [0.03%]
从禁食到脂肪重塑：间歇性禁食诱导的脂肪组织重塑的分子途径探究
Nathaniel Vo,Qiwei Zhang,Hoon-Ki Sung
Nathaniel Vo
Obesity, characterised by excessive fat accumulation, is a complex chronic condition that results from dysfunctional adipose tissue expansion due to prolonged calorie surplus. This leads to rapid adipocyte enlargement that exceeds the suppo...
Brinda Prapaharan,Micah Lea,Jacqueline L Beaudry
Brinda Prapaharan
Brown adipose tissue (BAT) activation is an emerging target for obesity treatments due to its thermogenic properties stemming from its ability to shuttle energy through uncoupling protein 1 (Ucp1). Recent rodent studies show how BAT and whi...
Lipoprotein lipase as a target for obesity/diabetes related cardiovascular disease [0.03%]
脂蛋白脂肪酶作为肥胖/糖尿病相关心血管疾病的靶点
Rui Shang,Brian Rodrigues
Rui Shang
Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being their leading cause of death. Traditionally, the management of obesity and diabetes has focused mainly on weight reduction and controlling high blood...
The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance [0.03%]
支链氨基酸及其下游代谢产物介导胰岛素抵抗的作用机制
Abdualrahman Mohammed Abdualkader,Qutuba G Karwi,Gary D Lopaschuk et al.
Abdualrahman Mohammed Abdualkader et al.
Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite extensive research, the precise mechanisms linking increased BCA...