Refined pharmacovigilance assessment of immune checkpoint inhibitors-related bullous pemphigoid: a multi-methodological approach utilizing FAERS database [0.03%]
利用FAERS数据库多方法学评估免疫检查点抑制剂相关大疱性类天疱疮的药物警戒事件
Yan Wang,Liu-Yi-Yi Yang,Ya-Gang Zuo
Yan Wang
Objectives: To evaluate the potential risk of bullous pemphigoid (BP) in patients treated with immune checkpoint inhibitors (ICIs) and to characterize ICI-related BP (irBP) using the United States Food and Drug Administra...
Harnessing DNA polymerase beta defect enhances synthetic lethality and treatment response in gastric cancer cells: implication for immunotherapy [0.03%]
DNA聚合酶β缺陷增强合成致死率和胃癌细胞治疗反应：对免疫疗法的意义
Aashirwad Shahi,Shengyuan Zhao,Dawit Kidane
Aashirwad Shahi
Gastric cancer remains a highly prevalent and accounts for a notable proportion of global cancer mortality. Both Intrinsic and exogenous agents can exacerbate reactive oxygen species (ROS) related oxidized DNA base lesions and single strand...
Intrahepatic cholestasis of pregnancy associated with azathioprine: first quantitative disproportionality analysis using the FDA adverse event reporting system [0.03%]
孕期与AZA相关的肝内胆汁淤积的首例定量不对比例分析（来自美国食品药品监督管理局不良事件报告系统）
Yonghoon Kwon,Nai Lee,Yun Kim
Yonghoon Kwon
Introduction: Azathioprine (AZA) is an immunosuppressant approved for renal transplant rejection and rheumatoid arthritis. Recent FDA alerts have raised concerns about its link to intrahepatic cholestasis of pregnancy (IC...
Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome [0.03%]
药理学增加循环酮体无法缓解Tafazzin敲低小鼠巴尔特综合征心肌病表型
Tanin Shafaati,Amanda A Greenwell,Christina T Saed et al.
Tanin Shafaati et al.
Objective: Mutations in the tafazzin gene lead to impaired remodeling of cardiolipin, thereby impairing mitochondrial function and causing Barth syndrome (BTHS), a rare X-linked genetic disorder characterized by cardiomyo...
Compounding and stability studies of liquid oral formulations of beta-blockers (bisoprolol, betaxolol, and nadolol) for paediatric patients [0.03%]
β受体阻滞剂（比索洛尔、贝他洛尔和纳多洛尔）液体制剂的复方及稳定性研究（用于儿科患者）
Laura Dubois,Cyrielle Bouguergour,Romain Paoli-Lombardo et al.
Laura Dubois et al.
In paediatric wards, bisoprolol, betaxolol, or nadolol can be administered orally at non-licensed dosages. To provide paediatric patients with appropriate treatment, batches of beta-blocker oral suspensions must be compounded, which involve...
Reuse of unused medications: a cross-sectional study on public willingness and influencing factors [0.03%]
关于药物再利用的横断面研究：公众意愿及影响因素分析
Faten Alhomoud,Sakinah Alalwyat,Lama Alanzi et al.
Faten Alhomoud et al.
Medication waste is a significant global concern with environmental, economic, and healthcare implications. In Saudi Arabia, approximately 25.8% of dispensed medications are wasted, resulting in an annual cost of $150 million. Re-dispensing...
Hypoglycemia and associated cardiovascular diseases, morbidity and mortality in patients with type 2 diabetes mellitus in university teaching hospitals in Rwanda [0.03%]
Rwanda大学教学医院中2型糖尿病患者的低血糖及相关的发病率和死亡率心血管疾病
Jean Baptiste Nyandwi,Pierre Celestin Munezero,Charles Uwambajimana et al.
Jean Baptiste Nyandwi et al.
Background: Hypoglycemia is a common yet underrecognized complication in patients with type 2 diabetes mellitus (T2DM), often linked with increased cardiovascular (CV) morbidity and mortality. Despite its clinical importa...
Standard formulas and individualised parenteral nutrition preparations in very low birth weight infants [0.03%]
极低出生体重儿的标准配方和个体化肠外营养准备
Laurie Dez,Stéphane Haÿs,Gilles Leboucher et al.
Laurie Dez et al.
Background/objectives: Optimal nutrition in very low birth weight (VLBW) infants is associated with improved clinical outcomes. When parenteral nutrition (PN) with a marketing authorisation is not appropriate, hospital ph...
Development of a submicron emulsion-based delivery system to improve the anti-inflammatory activity of urolithin A [0.03%]
基于亚微米乳剂递送系统开发提高 ellithin A抗炎活性的方法
Elisabetta Esposito,Valentyn Dzyhovskyi,Federico Santamaria et al.
Elisabetta Esposito et al.
Objective: Despite the antioxidant, anti-inflammatory, and anti-cellular-aging activities of urolithin A (UroA), a naturally occurring postbiotic, its high lipophilicity hampers its pharmaceutical application. To overcome...
Zaleplon nanospanlastics loaded transdermal patches: formulation, optimization, ex-vivo permeation, and in-vivo studies [0.03%]
zaleplon纳米颗粒经皮吸收贴剂：处方，优化，体外透皮及体内研究
Ahmed A El-Shenawy,Reham A Abd Elkarim,Reda A Mahmoud et al.
Ahmed A El-Shenawy et al.
Zaleplon (ZLP) is a commonly used sedative-hypnotic drug that has low oral bioavailability because of its poor water solubility and extensive hepatic metabolism. This study aimed to encapsulate ZLP into spanlastic nanovesicles to enhance it...