Editorial: Volume 2: real world evidence (RWE): paths to enhancing patient access to new medications [0.03%]
社论：第2卷：真实世界证据（RWE）：增强患者获取新药的途径
Allison Wills,Catherine Y Lau
Allison Wills
Corrigendum: Optimized Ginkgo biloba extract EGb 761®: boosted therapeutic benefits with minimized CYP enzyme interference [0.03%]
更正：优化的银杏叶提取物EGb 761：最大限度提高疗效，最小限度干扰CYP酶功能
Sunbeom Kwon,Suji Jeong,Seulah Lee
Sunbeom Kwon
[This corrects the article DOI: 10.3389/jpps.2025.14614.]. Keywords: CYP inhibition; EGb 761®; cognitive en...
The effect of cryoprotectant and storage conditions on the aggregation of poly(ethylene glycol)-poly(α-benzyl carboxylate-ε-caprolactone) nanoparticles [0.03%]
冻保护剂和储存条件对聚乙二醇-聚α-苄基焦谷酸-己内酯纳米粒子聚集的影响
Nasim Sarrami,Soheyla Honary,Mohammad Reza Vakili et al.
Nasim Sarrami et al.
Introduction: The preparation of nanoparticles (NPs) in aqueous media leads to thermodynamic instability and aggregation during storage. The objective of this study was to identify an optimum condition for the storage of ...
Targeted therapy and biomarker-guided applications of ecofriendly silver nanoparticles in precision oncology [0.03%]
用于精确诊断学的生物标志物导向型生态友好银纳米颗粒靶向疗法及应用
Haider Hamzah
Haider Hamzah
Eco-friendly silver nanoparticles (eco-AgNPs) represent a promising convergence of green nanotechnology and precision medicine for cancer treatment. This minireview examines the therapeutic potential of silver nanoparticles (AgNPs) synthesi...
Real-world safety profile of roflumilast: a pharmacovigilance analysis using FDA adverse event reporting system and Canada vigilance database [0.03%]
罗氟司特在真实世界中的安全特性：基于美国食品和药物管理局不良事件报告系统及加拿大监测数据库的药物流行病学分析
Rui Xu,Hui Peng,Chang Shu et al.
Rui Xu et al.
Background: Roflumilast, a highly selective phosphodiesterase 4 inhibitor, is used to treat with chronic obstructive pulmonary disease and psoriasis. We aim to determine potential roflumilast-associated adverse events (AE...
Enhancement of oral bioavailability of risedronate through xyloglucan rafts [0.03%]
黄原胶分子马达递药系统促进利塞磷酸盐口服吸收研究
Nader I Namazi,Rawan Bafail,Abdulkareem Ali Alanezi et al.
Nader I Namazi et al.
Bisphosphonates irritate the stomach and oesophagus and have a very limited absorption. The purpose of this study was to increase risedronate (RDN) oral bioavailability by causing a raft to form in the stomach. The creation of a raft preven...
Refined pharmacovigilance assessment of immune checkpoint inhibitors-related bullous pemphigoid: a multi-methodological approach utilizing FAERS database [0.03%]
利用FAERS数据库多方法学评估免疫检查点抑制剂相关大疱性类天疱疮的药物警戒事件
Yan Wang,Liu-Yi-Yi Yang,Ya-Gang Zuo
Yan Wang
Objectives: To evaluate the potential risk of bullous pemphigoid (BP) in patients treated with immune checkpoint inhibitors (ICIs) and to characterize ICI-related BP (irBP) using the United States Food and Drug Administra...
Harnessing DNA polymerase beta defect enhances synthetic lethality and treatment response in gastric cancer cells: implication for immunotherapy [0.03%]
DNA聚合酶β缺陷增强合成致死率和胃癌细胞治疗反应：对免疫疗法的意义
Aashirwad Shahi,Shengyuan Zhao,Dawit Kidane
Aashirwad Shahi
Gastric cancer remains a highly prevalent and accounts for a notable proportion of global cancer mortality. Both Intrinsic and exogenous agents can exacerbate reactive oxygen species (ROS) related oxidized DNA base lesions and single strand...
Intrahepatic cholestasis of pregnancy associated with azathioprine: first quantitative disproportionality analysis using the FDA adverse event reporting system [0.03%]
孕期与AZA相关的肝内胆汁淤积的首例定量不对比例分析（来自美国食品药品监督管理局不良事件报告系统）
Yonghoon Kwon,Nai Lee,Yun Kim
Yonghoon Kwon
Introduction: Azathioprine (AZA) is an immunosuppressant approved for renal transplant rejection and rheumatoid arthritis. Recent FDA alerts have raised concerns about its link to intrahepatic cholestasis of pregnancy (IC...
Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome [0.03%]
药理学增加循环酮体无法缓解Tafazzin敲低小鼠巴尔特综合征心肌病表型
Tanin Shafaati,Amanda A Greenwell,Christina T Saed et al.
Tanin Shafaati et al.
Objective: Mutations in the tafazzin gene lead to impaired remodeling of cardiolipin, thereby impairing mitochondrial function and causing Barth syndrome (BTHS), a rare X-linked genetic disorder characterized by cardiomyo...