Standard formulas and individualised parenteral nutrition preparations in very low birth weight infants [0.03%]
极低出生体重儿的标准配方和个体化肠外营养准备
Laurie Dez,Stéphane Haÿs,Gilles Leboucher et al.
Laurie Dez et al.
Background/objectives: Optimal nutrition in very low birth weight (VLBW) infants is associated with improved clinical outcomes. When parenteral nutrition (PN) with a marketing authorisation is not appropriate, hospital ph...
Development of a submicron emulsion-based delivery system to improve the anti-inflammatory activity of urolithin A [0.03%]
基于亚微米乳剂递送系统开发提高 ellithin A抗炎活性的方法
Elisabetta Esposito,Valentyn Dzyhovskyi,Federico Santamaria et al.
Elisabetta Esposito et al.
Objective: Despite the antioxidant, anti-inflammatory, and anti-cellular-aging activities of urolithin A (UroA), a naturally occurring postbiotic, its high lipophilicity hampers its pharmaceutical application. To overcome...
Zaleplon nanospanlastics loaded transdermal patches: formulation, optimization, ex-vivo permeation, and in-vivo studies [0.03%]
zaleplon纳米颗粒经皮吸收贴剂：处方，优化，体外透皮及体内研究
Ahmed A El-Shenawy,Reham A Abd Elkarim,Reda A Mahmoud et al.
Ahmed A El-Shenawy et al.
Zaleplon (ZLP) is a commonly used sedative-hypnotic drug that has low oral bioavailability because of its poor water solubility and extensive hepatic metabolism. This study aimed to encapsulate ZLP into spanlastic nanovesicles to enhance it...
A survey of regulatory recommendations for waivers of in vivo bioequivalence studies of generic products for certain dosage forms by participating regulators and organisations of the International Pharmaceutical Regulators Programme. Part 2 [0.03%]
国际药品监管机构计划参与监管机构和组织对某些给药形式仿制药体内生物等效性研究豁免的监管建议调查。第二部分
Alfredo García-Arieta,Andrew Tam,Florencia Tiseyra et al.
Alfredo García-Arieta et al.
A biowaiver generally refers to the request to waive an in vivo bioequivalence study. A biowaiver may be granted not only based on the Biopharmaceutics Classifications System (BCS) but also for many immediate-release dosage forms based on p...
The need to redefine diabetic cardiomyopathy as a unique clinical entity that requires pharmacotherapy [0.03%]
糖尿病心肌病是一种需要药物治疗的独特临床实体，该疾病需重新定义
Alexa N King,John R Ussher
Alexa N King
Personalizing immunosuppressive therapy: predictors of drug switches in Malaysian kidney transplant recipients [0.03%]
马来西亚肾移植受者的免疫抑制治疗转换因素分析
Chiau Ling Choong,Farida Islahudin,Mohd Makmor-Bakry et al.
Chiau Ling Choong et al.
Objective: Tacrolimus-mycophenolic acid (MPA)-prednisolone immunosuppression remains the first-line management of kidney transplantation. Despite this, a switch to low-dose tacrolimus in combination with an mTOR inhibitor...
Corrigendum: Metabolic flux in macrophages in obesity and type-2 diabetes [0.03%]
肥胖和2型糖尿病中巨噬细胞的代谢通量の勘误公告
Angela Wong,Qiuyu Sun,Ismail Ibrahim Latif et al.
Angela Wong et al.
[This corrects the article DOI: 10.3389/jpps.2024.13210.]. Keywords: amino acids; fatty acids; glucose; keto...
Adverse drug events associated with tiotropium: a real-world pharmacovigilance study of FDA adverse event reporting system database [0.03%]
托特罗定相关不良事件的药物警戒研究
Yang Rui,Tianyuan Xin,Yu Chen et al.
Yang Rui et al.
Introduction: Tiotropium, a long-acting muscarinic antagonist, is commonly employed for the maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma. While its efficacy has been validated through n...
A systematic review of real-world evidence on the clinical relevance, characterization, and utility of CYP2D6 biomarker testing [0.03%]
一项关于CYP2D6生物标志物检测的临床相关性、特征和应用的现实世界证据系统评价
Patrick Rodriguez,Emma Kikerkov,Nora Emmott et al.
Patrick Rodriguez et al.
Pharmacogenomic (PGx) research investigates how an individual's genetic make-up impacts their drug metabolism. PGx testing can therefore inform therapeutic decision-making, especially as compelling evidence develops over time to substantiat...
Optimized Ginkgo biloba extract EGb 761®: boosted therapeutic benefits with minimized CYP enzyme interference [0.03%]
优化的银杏叶提取物EGb 761：提高疗效并减少对CYP酶的影响
Sunbeom Kwon,Suji Jeong,Seulah Lee
Sunbeom Kwon
Object: The development of cognitive-enhancing drugs from Ginkgo biloba extract is actively pursued worldwide. This study compares the chemical compositions of different G. biloba extracts and their formulated drugs, high...