Abstracts of poster presentations at the 2021 virtual annual of the Canadian Society for Pharmaceutical Sciences [0.03%]
2021年加拿大制药科学虚拟年度会议上张贴的海报摘要
Kristine Warman
Kristine Warman
In 2021, the Canadian Society for Pharmaceutical Sciences (CSPS) partnered with the Pharmaceutical Society of Japan (PSJ) and the Canadian Chapter of Controlled Release Society (CC-CRS) to present its annual meeting in the virtual style. Ke...
Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms [0.03%]
双光动力疗法有效清除口腔链球菌生物膜
Jessica Hentilä,Noora Laakamaa,Timo Sorsa et al.
Jessica Hentilä et al.
Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the he...
Clinical Importance of Plasma Drug Concentration of Oral Molecular Targeted Drugs for Renal Cell Carcinoma [0.03%]
口服肾细胞癌分子靶向药物血浆浓度的临床意义
Shinya Takasaki,Yoshihide Kawasaki,Masafumi Kikuchi et al.
Shinya Takasaki et al.
Purpose: Therapeutic drug monitoring (TDM) is widely used in clinical practice to maximize drug efficacy and minimize toxicities. Currently, it is also practiced in the use of oral molecular targeted drugs. The objective ...
Angiotensin-Converting Enzyme Inhibitor Induced Cough in Chinese Patients: a Systematic Review and Meta-analysis [0.03%]
血管紧张素转化酶抑制剂引起中国患者咳嗽的系统评价和荟萃分析
Ling Liang,Janice Y Kung,Bradley Mitchelmore et al.
Ling Liang et al.
Purpose: To determine the risk of angiotensin converting enzyme inhibitor (ACEI)-induced cough compared to non-ACEI cough among Chinese patients. Methods:...
Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds [0.03%]
表达功能人有机阴离子转运多肽(OATP)1B3的夹层培养大鼠肝细胞模型的建立：一种潜在的肝脏靶向化合物筛选工具
Taleah Farasyn,Chao Xu,Wei Yue
Taleah Farasyn
Purpose: Organic anion transporting polypeptide (OATP) 1B3 transports many clinically important drugs, including statins, from blood into the liver. It exclusively expresses in human liver under normal physiological condi...
Factors Influencing 1st and 2nd Generation Drug-Eluting Stent Performance: Understanding the Basic Pharmaceutical Drug-in-Polymer Formulation Factors Contributing to Stent Thrombosis Do We Really Need to Eliminate the Polymer? [0.03%]
影响第一代和第二代药物洗脱支架性能的因素：理解药物-高分子配方的基本药理学因素对支架血栓形成的贡献真的需要去除聚合物吗？
Iva Srdanovic
Iva Srdanovic
Drug-eluting stents (DES) have a major role in treating cardiovascular disease. The evolution of bare metal stents into 1st generation durable-polymer DES (DP-DES) reduced the rate of in-stent restenosis (ISR) and the need for repeat-revasc...
Explosions, Burn Injuries and Adverse Health Effects of Electronic Nicotine Delivery Systems: A Review of Current Regulations and Future Perspectives [0.03%]
电子尼古丁输送系统爆炸、灼伤及其他不良健康影响：现有规定及未来展望综述
Ayesha Rahman Ahmed,Beverly Etchey,Mahiba Ahmed
Ayesha Rahman Ahmed
Purpose: While there is a declining trend in the use of traditional methods of smoking tobacco, electronic nicotine delivery systems (ENDS) have gained popularity worldwide. ENDS are marketed as safe for the primary reaso...
Synthesis of New Hybrid Derivatives from Metronidazole and Eugenol Analogues as Trypanocidal Agents [0.03%]
基于甲硝唑和丁香酚类似物的杂化衍生物作为抗锥虫剂的合成研究
Mônica Fraccarolli Pelozo,Giovanna Fiori Serpa Lima,Cleydson Finotti Cordeiro et al.
Mônica Fraccarolli Pelozo et al.
Background: The search for new drug compounds is always challenging and there are several different strategies that involve the most varied and creative approaches in medicinal chemistry. One of them is the technique of m...
Li-Juan Zhu,Chengcheng Zhang,Ce Chen
Li-Juan Zhu
Neurons are special polarized cells whose synaptic vesicles release neurotransmitters into the synaptic cleft, acting on postsynaptic receptors and thus transmitting information from presynaptic to postsynaptic states. The integrity of the ...
Professor Endrenyi's Legacy: An Evaluation of the Regulatory Requirement "Fixed Effects, Rather Than Random Effects, Should Be Used for All Terms" [0.03%]
Endrenyi教授的遗产：评估“固定效应而非随机效应应被用于所有项”的法规要求
Anders Fuglsang
Anders Fuglsang
Purpose: In the latest revision of the guideline for evaluation of bioequivalence (BE), European regulators introduced the requirement for using subjects as fixed factors in the underlying statistical models, even in repl...