Experimental estimation of the role of P-Glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the Caco-2 cell model [0.03%]
Jean I Pachot,Roger P Botham,Klaus D Haegele et al.
Jean I Pachot et al.
Purpose: The aim of this study was to examine the transport mechanism of telithromycin in comparison with erythromycin, azithromycin, clarithromycin and roxithromycin. ...
Hydroxypropyl-beta-cyclodextrin-flutamide inclusion complex. II. Oral and intravenous pharmacokinetics of flutamide in the rat [0.03%]
2-羟丙基-B-环糊精-氟他胺包合物的口服和静脉给药动力学研究(英文)
Zhong Zuo,Yun K Tam,James Diakur et al.
Zhong Zuo et al.
Purpose: The objective of this work was to determine the pharmacokinetics of flutamide (FLT) and its active metabolite, 2-hydroxy-flutamide (FLT-2-OH) in rats, following formulation in hydroxypropyl-Beta-cyclodextrin (FLT...
Mathematical modelling of preparation of acyclovir liposomes: reverse phase evaporation method [0.03%]
阿昔洛韦脂质体反向蒸发法制备的数学模型研究
Avinash Kumar Seth,Ambikanandan Misra
Avinash Kumar Seth
Purpose: The aim of this study was to derive simple reduced second order polynomial equation for constructing contour plots to obtain predetermined % drug entrapment (PDE) within liposomes of acyclovir (ACY) when prepared...
M E Christine Lutsiak,Glen S Kwon,John Samuel
M E Christine Lutsiak
Purpose: To evaluate several methods for extraction of peptides from liposomal formulations as a first step in their quantification, and to determine the encapsulation efficiency for a panel of 8 peptides. ...
Response surface optimization of the critical medium components for the production of alkaline protease by a newly isolated Bacillus sp [0.03%]
通过正交实验优化新分离芽孢杆菌产生碱性蛋白酶的培养基成分
K Adinarayana,P Ellaiah
K Adinarayana
Purpose: Optimization of the fermentation medium for maximum alkaline protease production was carried out using a new strain, Bacillus Sp. PE-11. Methods:...
Synthesis of isatin semicarbazones as novel anticonvulsants--role of hydrogen bonding [0.03%]
氢键在新型抗惊厥药异咯酸半卡比酮合成中的作用
Surendra Nath Pandeya,Ayyannan Senthil Raja,James P Stables
Surendra Nath Pandeya
Purpose: A series of substituted isatin semicarbazones and related bioisosteric hydrazones were designed and synthesised to meet the structural requirements essential for anticonvulsant properties. ...
Molecular descriptor based on a molar refractivity partition using Randic-type graph-theoretical invariant [0.03%]
基于瑞提类型图论不变量的摩尔折射率划分的分子描述符
J A Padrón,R Carrasco,R F Pellón
J A Padrón
Purpose: Development of a novel semi-empirical descriptor (MR(chi) for molecular modelling. Method: The index is based on a molar refra...
Molecular modeling of potential new and selective PET radiotracers for the serotonin transporter. Positron Emission Tomography [0.03%]
新型选择性血清素摄取体的潜在正电子发射断层显像剂的分子建模研究
Julia Wellsow,Karl-Artur Kovar,Hans-Jürgen Machulla
Julia Wellsow
Purpose: Imaging the serotonin transporter (SERT) with Positron Emission Tomography (PET) provides a useful tool for understanding alterations of the serotonergic system. However, no optimal PET radiotracer for the SERT y...
Ahmed Kashif Alavi,Emilio Squillante rd,Ketan A Mehta
Ahmed Kashif Alavi
Purpose: A microencapsulation method that preserves the activity of an acid labile protein was developed. Methods: Solvent evaporation ...
Fatty acid composition of Dracunculus vulgaris Schott (Araceae) seed oil from Turkey [0.03%]
土耳其Dracunculus vulgaris Schott (天南星科)种子油的脂肪酸组成
Serap Saglik,Kerim Alpnar,Sedat Imre
Serap Saglik
Dracunculus vulgaris Schott is only one taxon of the genus Dracunculus (Araceae) in Turkey. The tubers and the fruits with the seeds of D. vulgaris have long been in use for the treatment of rheumatism and hemorrhoids, respectively. The fat...