Monkeypox: Virology, Pathophysiology, Clinical Characteristics, Epidemiology, Vaccines, Diagnosis, and Treatments [0.03%]
猴痘病毒学、病理生理、临床特征、流行病学、疫苗、诊断和治疗
Marzieh Soheili,Sherko Nasseri,Maryam Afraie et al.
Marzieh Soheili et al.
The World Health Organization, has declared the recent multiregional outbreak of monkeypox, a global public health emergency. Monkeypox is a zoonotic viral infection endemic to the west and central Africa. It belongs to the Poxviridae famil...
Helmut Schütz,Detlew Labes,Martin J Wolfsegger
Helmut Schütz
Purpose: More than a decade ago the option to assess highly variable drugs / drug products by reference-scaled average bioequivalence was introduced in regulatory practice. Recommended approaches differ between jurisdicti...
Efficacy and Safety of Anticoagulants for COVID-19 Patients in the Intensive Care Unit: A Systematic Review and Meta-Analysis [0.03%]
抗凝药物治疗重症监护病房中新冠肺炎患者的疗效和安全性：系统评价和 meta 分析
Yulistiani,Vina Neldi,Budi Suprapti et al.
Yulistiani et al.
Purpose: This study aims to analyze the efficacy and safety of anticoagulants for COVID-19 patients in the intensive care unit. Methods: ...
Evaluation of Clinical Outcomes of Intravenous Drug Use-Related Infective Endocarditis in Buprenorphine-Treated Patients [0.03%]
丁丙诺啡治疗对静脉药物滥用相关感染性心内膜病临床疗效的影响评估
Cavan O&#x;Kane,Kara Piechowski,Abigail Hoff et al.
Cavan O&#x;Kane et al.
Purpose: Intravenous drug use (IVDU) is an independent risk factor for infective endocarditis (IE). IVDU-related IE is associated with poor clinical outcomes, such as infection-related and drug abuse-related readmissions ...
Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy [0.03%]
探索钠-葡萄糖同向转运蛋白作为癌症治疗的新靶点
Sanaa Bardaweel,Ahmad Issa
Sanaa Bardaweel
Purpose: To evaluate the effects of SGLT2 inhibitors on the proliferation, tumorigenesis, migration, colony formation, apoptosis, selected gene expression pattern, and combination with known chemotherapeutic drugs in diff...
Effect of Concomitant Drug Use on the Onset and Exacerbation of Diabetes Mellitus in Everolimus-Treated Cancer [0.03%]
接受依维莫司治疗的癌症患者中并发用药对糖尿病发病和恶化的 影响
Katsuhiro Ohyama,Hiroyuki Tanaka,Yusuke Hori
Katsuhiro Ohyama
Purpose: Everolimus-induced diabetes mellitus (DM) outcomes include everolimus-resistant tumors and poor hyperglycemia outcomes, which lead to various other negative clinical outcomes. This study aimed to evaluate the eff...
Torsade de Pointes/QT Prolongation Associated with Antifungal Triazoles: A Pharmacovigilance Study Based on the U.S. FDA Adverse Event Reporting System（FAERS） [0.03%]
基于美国FDA不良事件报告系统（FAERS）的抗真菌三唑类药物致尖端扭转室速/QT间期延长的信号检测研究
Zicheng Yu,Xiaolan Liao
Zicheng Yu
Purpose: Torsade de pointes (TdP)/QT prolongation is a fatal adverse event (AE) when using antifungal triazoles. We aimed to compare the AE signals of TdP/QT prolongation and onset time among different drugs of this kind ...
Progress and Prospects of Research Ideas and Methods in the Network Pharmacology of Traditional Chinese Medicine [0.03%]
网络药理学研究思路与方法的进展和展望
Zhongzhu Yuan,Yingying Pan,Tian Leng et al.
Zhongzhu Yuan et al.
In recent years, the emerging network pharmacology has been extensively applied to the field of traditional Chinese medicine and has made great contributions to the modernization of TCM. Therefore, this paper provides an overview of the pro...
Health Canada Usage of Real World Evidence (RWE) in Regulatory Decision Making compared with FDA/EMA usage based on publicly available information [0.03%]
基于公开信息的健康加拿大真实世界证据（RWE）监管决策应用与FDA/EMA的应用相比如何
Catherine Lau,Fakhreddin Jamali,Raimar Loebenberg
Catherine Lau
Purpose: Between January 2020 and December 2021, Health Canada provided a Summary Basis of Decision (SBD) for each of 110 products approved, including 29 oncology products and 21 non-oncology orphan drugs. This review sou...
Shiva Golshani,Alireza Vatanara,Mohsen Amin
Shiva Golshani
The oral cavity is one of the most important routes for local and systemic drug delivery, as it has a large surface, high permeability, and rich blood supply. Oral mucosal drug delivery has some advantages, such as enhancing bioavailability...