Targeted therapy and biomarker-guided applications of ecofriendly silver nanoparticles in precision oncology [0.03%]
用于精确诊断学的生物标志物导向型生态友好银纳米颗粒靶向疗法及应用
Haider Hamzah
Haider Hamzah
Eco-friendly silver nanoparticles (eco-AgNPs) represent a promising convergence of green nanotechnology and precision medicine for cancer treatment. This minireview examines the therapeutic potential of silver nanoparticles (AgNPs) synthesi...
Real-world safety profile of roflumilast: a pharmacovigilance analysis using FDA adverse event reporting system and Canada vigilance database [0.03%]
罗氟司特在真实世界中的安全特性：基于美国食品和药物管理局不良事件报告系统及加拿大监测数据库的药物流行病学分析
Rui Xu,Hui Peng,Chang Shu et al.
Rui Xu et al.
Background: Roflumilast, a highly selective phosphodiesterase 4 inhibitor, is used to treat with chronic obstructive pulmonary disease and psoriasis. We aim to determine potential roflumilast-associated adverse events (AE...
Enhancement of oral bioavailability of risedronate through xyloglucan rafts [0.03%]
黄原胶分子马达递药系统促进利塞磷酸盐口服吸收研究
Nader I Namazi,Rawan Bafail,Abdulkareem Ali Alanezi et al.
Nader I Namazi et al.
Bisphosphonates irritate the stomach and oesophagus and have a very limited absorption. The purpose of this study was to increase risedronate (RDN) oral bioavailability by causing a raft to form in the stomach. The creation of a raft preven...
Refined pharmacovigilance assessment of immune checkpoint inhibitors-related bullous pemphigoid: a multi-methodological approach utilizing FAERS database [0.03%]
利用FAERS数据库多方法学评估免疫检查点抑制剂相关大疱性类天疱疮的药物警戒事件
Yan Wang,Liu-Yi-Yi Yang,Ya-Gang Zuo
Yan Wang
Objectives: To evaluate the potential risk of bullous pemphigoid (BP) in patients treated with immune checkpoint inhibitors (ICIs) and to characterize ICI-related BP (irBP) using the United States Food and Drug Administra...
Harnessing DNA polymerase beta defect enhances synthetic lethality and treatment response in gastric cancer cells: implication for immunotherapy [0.03%]
DNA聚合酶β缺陷增强合成致死率和胃癌细胞治疗反应：对免疫疗法的意义
Aashirwad Shahi,Shengyuan Zhao,Dawit Kidane
Aashirwad Shahi
Gastric cancer remains a highly prevalent and accounts for a notable proportion of global cancer mortality. Both Intrinsic and exogenous agents can exacerbate reactive oxygen species (ROS) related oxidized DNA base lesions and single strand...
Intrahepatic cholestasis of pregnancy associated with azathioprine: first quantitative disproportionality analysis using the FDA adverse event reporting system [0.03%]
孕期与AZA相关的肝内胆汁淤积的首例定量不对比例分析（来自美国食品药品监督管理局不良事件报告系统）
Yonghoon Kwon,Nai Lee,Yun Kim
Yonghoon Kwon
Introduction: Azathioprine (AZA) is an immunosuppressant approved for renal transplant rejection and rheumatoid arthritis. Recent FDA alerts have raised concerns about its link to intrahepatic cholestasis of pregnancy (IC...
Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome [0.03%]
药理学增加循环酮体无法缓解Tafazzin敲低小鼠巴尔特综合征心肌病表型
Tanin Shafaati,Amanda A Greenwell,Christina T Saed et al.
Tanin Shafaati et al.
Objective: Mutations in the tafazzin gene lead to impaired remodeling of cardiolipin, thereby impairing mitochondrial function and causing Barth syndrome (BTHS), a rare X-linked genetic disorder characterized by cardiomyo...
Compounding and stability studies of liquid oral formulations of beta-blockers (bisoprolol, betaxolol, and nadolol) for paediatric patients [0.03%]
β受体阻滞剂（比索洛尔、贝他洛尔和纳多洛尔）液体制剂的复方及稳定性研究（用于儿科患者）
Laura Dubois,Cyrielle Bouguergour,Romain Paoli-Lombardo et al.
Laura Dubois et al.
In paediatric wards, bisoprolol, betaxolol, or nadolol can be administered orally at non-licensed dosages. To provide paediatric patients with appropriate treatment, batches of beta-blocker oral suspensions must be compounded, which involve...
Reuse of unused medications: a cross-sectional study on public willingness and influencing factors [0.03%]
关于药物再利用的横断面研究：公众意愿及影响因素分析
Faten Alhomoud,Sakinah Alalwyat,Lama Alanzi et al.
Faten Alhomoud et al.
Medication waste is a significant global concern with environmental, economic, and healthcare implications. In Saudi Arabia, approximately 25.8% of dispensed medications are wasted, resulting in an annual cost of $150 million. Re-dispensing...
Hypoglycemia and associated cardiovascular diseases, morbidity and mortality in patients with type 2 diabetes mellitus in university teaching hospitals in Rwanda [0.03%]
Rwanda大学教学医院中2型糖尿病患者的低血糖及相关的发病率和死亡率心血管疾病
Jean Baptiste Nyandwi,Pierre Celestin Munezero,Charles Uwambajimana et al.
Jean Baptiste Nyandwi et al.
Background: Hypoglycemia is a common yet underrecognized complication in patients with type 2 diabetes mellitus (T2DM), often linked with increased cardiovascular (CV) morbidity and mortality. Despite its clinical importa...