Long-term Storage of Diluted Antibody in Tris-buffered Saline with Tween 20 [0.03%]
吐温-20含三羟甲基氨基甲烷缓冲盐水中的低浓抗体长期保存稳定性研究
Sunmin Kwon,Ha-Na Park,Min Seok Song et al.
Sunmin Kwon et al.
Background: Western blotting is a fundamental technique for protein detection and quantification, with critical dependence on antibody for its sensitivity and specificity. Antibody solutions are frequently reused to conse...
Anti-CD133-grafted single-walled carbon nanotubes as doxorubicin carrier [0.03%]
抗CD133单壁碳纳米管载多柔比星送递体系
Elham Momeni,Rahime Eshaghi Malekshah,Ali Khaleghian et al.
Elham Momeni et al.
Background: Advances in nanomedicine have spurred interest in antibody-conjugated carbon nanotubes for targeted cancer therapy. CD133, a marker enriched in chemoresistant cancer stem cells, presents a strategic target for...
Inhalable Herbal Nano-Liposomes Co-Delivering Astragaloside IV and Polyphyllin VII Reprogram Immunosuppressive Microenvironment To Overcome Anti-PD-1 Resistance in NSCLC [0.03%]
可吸入的载黄芪苷IV和百秋李醇VII纳米脂质体制剂重编免疫抑制微环境以克服NSCLC中抗PD-1耐药性
Yao Liu,Tianqi An,Zujun Que et al.
Yao Liu et al.
Non-small cell lung cancer (NSCLC) frequently develops acquired resistance to immune checkpoint inhibitors (ICIs), necessitating innovative strategies to remodel the immunosuppressive tumor microenvironment (TME). This study engineered an i...
Pan-Cancer Landscape of Magnesium Homeostasis: Bulk Omics Research and Single-Cell Sequencing Validation [0.03%]
泛癌镁稳态全景图：组学分析与单细胞测序验证
Yan Qin,Zhuo-Er Yuan,De Yin et al.
Yan Qin et al.
Introduction: Magnesium homeostasis is critical for cellular growth and metabolism, yet its pan-cancer implications remain poorly characterized. This study aims to comprehensively analyze magnesium homeostasis across 33 c...
Unraveling the Gut Microbiota-mediated Anti-tumor Mechanisms of ShenXia KuanZhong Decoction in Gastric Cancer: a Systems Biology and Dose-weighted Network Pharmacology Approach [0.03%]
基于系统生物学和剂量加权网络药理学的神效宽中汤胃癌治疗机制研究及微生物介导作用探讨
Ziyi Zhou,Yuan Fang,Lijie Song et al.
Ziyi Zhou et al.
Introduction: Gastric cancer (GC) remains a formidable global health issue with limited therapeutic options. ShenXia KuanZhong Decoction (SXKZD), a classical traditional Chinese medicine (TCM) formula, is used to manage G...
Uncovering Novel Susceptible Genes and Therapeutic Targets of Prostate Cancer: a Multi-omics Study Integrating Summary-based Mendelian Randomization Analysis and Molecular Docking [0.03%]
基于汇总数据的孟德尔随机化分析和分子对接整合多组学研究揭示新型前列腺癌易感基因与治疗靶点
Xuemeng Qiu,Yifei Zhang,Jiyue Wu et al.
Xuemeng Qiu et al.
Background: Understanding the role of causal genes of prostate cancer (PrCa) can reveal key biological pathways and identify potential targets for treatment. ...
Rap2B-mediated reprogramming of the PI3K/AKT signaling axis drives resistance to cetuximab-targeted therapy in colorectal carcinoma [0.03%]
Rap2B介导的PI3K / AKT信号轴重编程驱动结直肠癌对西妥昔单抗靶向治疗的耐药性
Shanshan Zhang,Ying Wei,Tingting Liu et al.
Shanshan Zhang et al.
Background: Targeted therapy resistance represents a significant clinical challenge in cancer treatment. Rap2B, a member of the Ras superfamily of small GTPases, is frequently overexpressed in various cancers and has been...
Impact of different mating and surgical protocols on the establishment of a mouse model for fetal scarless skin healing [0.03%]
不同交配和手术方案对建立胎儿伤口无瘢痕愈合小鼠模型的影响
Lu Huang,Xinran Ye,Yifan Zhang et al.
Lu Huang et al.
Background: The mouse fetal intrauterine wound healing model is crucial and commonly used for investigating mechanisms and evaluating potential therapies for scarless skin regeneration compared to fibrotic healing. Howeve...
Sheet Protector Strategy for Western Blot to Reduce Antibody Consumption and Incubation Time [0.03%]
Western印迹中使用膜保护器减少抗体消耗和孵育时间的策略
Sunmin Kwon,So Yeong Lee,Gun Kim
Sunmin Kwon
Background: Western blot is one of the most routinely conducted biochemical assays due to its technical ease and relatively low cost. The use of antibody is at the center of Western blot assay, providing great sensitivity...
SOCS3: An Immunological Biomarker Offering Potential Therapeutic Targets for Malignant Tumors [0.03%]
SOCS3：一个潜在的治疗恶性肿瘤免疫生物标志物及靶点
Yan Zhang,Meiling Chu,Meina Ye et al.
Yan Zhang et al.
Suppressor of Cytokine Signaling 3 (SOCS3) is a critical regulator of cytokine signaling, primarily acting through the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. It plays a significant role in the de...