A novel prognostic model based on MVIRGs identifies ANGPT2 as a key target driving the malignant progression of HCC [0.03%]
基于MVIRGs的新型预后模型鉴定出ANGPT2是驱动肝癌恶性进展的关键靶点
Xian Li,Zhouli Tan,Shanru Feng et al.
Xian Li et al.
Background: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with high recurrence and limited therapies. Microvascular invasion (MVI) is a critical prognostic factor, but its molecular mechanisms and precise p...
Lipid Metabolic Rewiring During Continuous Prostate Cancer Progression Defines a Biologically Relevant Four-Gene Prognostic Signature [0.03%]
连续前列腺癌进展期间的脂质代谢重构定义了一个具有生物学相关性的四基因预后标志物
Rongna Li,Hongying He,Hui Sun et al.
Rongna Li et al.
Background: Lipid metabolic reprogramming is increasingly recognized as a critical feature of prostate cancer progression, but the lipid metabolism-related genes that remain continuously dysregulated from normal tissue to...
Targeting Hyaluronan Signaling Overcomes Primary Effusion Lymphoma Cells Resistance to Rapamycin [0.03%]
靶向透明质酸信号可克服雷帕霉素对原发性渗出性淋巴瘤细胞的耐药性
Jungang Chen,Margaret Qin,Jiaojiao Fan et al.
Jungang Chen et al.
The oncogenic γ-herpesvirus known as the Kaposi's sarcoma-associated herpesvirus (KSHV) is a principal causative agent of several cancers arising in patients with compromised immune systems. One of KSHV-related malignancies, primary effusi...
Activation of PPARγ and CPT1A Mediates the Hepatoprotective Effect of Ginsenoside CK against NAFLD in Rats [0.03%]
人参皂苷CK通过激活PPARγ和CPT1A介导对大鼠NAFLD的保护作用
Danfeng Lan,Guishun Sun,Zhiyong Dong et al.
Danfeng Lan et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is a significant underlying driver of hepatocellular carcinoma; however, current clinical treatment options remain limited. Ginsenoside CK (CK), a natural bioactive com...
Ethnopharmacological evaluation and metabolic mechanism of Sanjie Xiaoliu Granule in breast cancer with depression [0.03%]
三捷消瘤颗粒治疗抑郁型乳腺癌的民族药理学评价及代谢机制研究
Zhuo Liu,Tianhao Tong,Renyi Yang et al.
Zhuo Liu et al.
Background: Sanjie Xiaoliu Granule (XJXLG), a traditional multi-herbal prescription widely used in Chinese medicine, has been historically applied to "disperse nodules, soothe the liver, and relieve depression." It is cli...
Identification and validation of serum SLIT1 as a biomarker for predicting anti-PD-1/PD-L1 resistance in non-small cell lung cancer [0.03%]
非小细胞肺癌抗PD-1/PD-L1耐药预测标志物SLIT1的鉴定和验证
Huisi Qiu,Cong Peng,Ziao Gao et al.
Huisi Qiu et al.
Background: Non-small cell lung cancer (NSCLC), the predominant subtype of lung cancer, contributes greatly to cancer-related mortality worldwide. Although inhibitors of programmed cell death protein 1 (PD-1) and its liga...
Prognostic Significance and Immune Landscape of Neuroendocrine Differentiation-Related Genes in Non-Small Cell Lung Cancer [0.03%]
非小细胞肺癌中神经内分泌分化相关基因的预后意义及免疫图谱
Tong Li,Meidan Luo,Sibo Peng et al.
Tong Li et al.
Background: Immunotherapy resistance represents a current research hotspot. Previous studies found that neuroendocrine differentiation (NED) might significantly contribute to the initiation and development of non-small ce...
4-Hydroxychalcone Exert the Anti-cancer Potential in Colorectal Cancer Through Targeting CDK6 [0.03%]
4-羟基查尔酮通过靶向CDK6在结直肠癌中发挥抗癌作用
Chenxin Yang,Mingxuan Huangfu,Xintong Dai et al.
Chenxin Yang et al.
Background: Colorectal cancer (CRC) is a prevalent and highly lethal malignancy characterized by frequent recurrence and high mortality. 4-Hydroxychalcone (4HC), a common chalcone abundant in daily foods, exhibits multipl...
Integrated Genomic and Single-Cell Analysis Identifies Notch1 as a Metastasis Suppressor in Nasopharyngeal Carcinoma Targeted by the AKT/Smad3 Axis [0.03%]
整合基因组和单细胞分析识别出Notch1是通过AKT/Smad3轴作用的鼻咽癌转移抑制子
Jingjing Zuo,Shiyong Huang,Mengyuan Dai et al.
Jingjing Zuo et al.
Background: Notch1 exhibits a high mutation rate in head and neck squamous cell carcinoma (HNSCC), but its functional role in nasopharyngeal carcinoma (NPC) invasion and metastasis remains incompletely understood. This st...
Evolutionary Trajectory of Radioresistance in Lung Cancer Brain Metastasis Organoids [0.03%]
肺癌脑转移类器官放疗抵抗的进化轨迹研究
Jianing Chen,Cize Gao,Li Wang et al.
Jianing Chen et al.