Felice Petraglia,Silvia Vannuccini,Marie-Madeleine Dolmans et al.
Felice Petraglia et al.
Endometriosis is a chronic gynecologic disease of reproductive-age women, causing menstrual pain and infertility. Endocrine and inflammatory mechanisms drive its development, with estrogen/progesterone imbalance contributing to extrauterine...
Natural history of non-functioning pituitary microadenomas: a systematic review and individual participant data meta-analysis [0.03%]
垂体非功能性微腺瘤的自然史：系统评价和个体患者数据meta分析
V B Boesen,T H Hansen,M Motawea et al.
V B Boesen et al.
Objective: Increased frequency of neuroimaging has led to enhanced identification of small non-functioning pituitary adenomas (NFPAs) leading, in many cases, to extensive follow-up. However, the value of ongoing monitorin...
Serum steroid metabolome dynamics in infancy: a longitudinal cohort study of healthy infants [0.03%]
婴儿期血清类固醇代谢组的动态变化：健康婴儿的纵向队列研究
Alexander Siegfried Busch,Marie Lindhardt Ljubicic,Emmie N Upners et al.
Alexander Siegfried Busch et al.
Objective: The circulating steroid metabolome exhibits significant changes in both girls and boys during infancy, reflecting structural and functional changes in the adrenal cortex as well as the transient activation of t...
Estimated Global Prevalence of Genetic Carriers of Hereditary Pheochromocytoma-Paraganglioma Syndrome in a Large Multiethnic Genomic Database [0.03%]
估计的大规模多民族基因组数据库中遗传性嗜铬细胞瘤副神经节瘤综合征携带者的全球患病率
Nipith Charoenngam,Taweesak Wannachalee
Nipith Charoenngam
Objectives: To estimate the global prevalence of genetic carriers of pheochromocytoma-paraganglioma syndromes (PPGLs) in a large multiethnic genomic database. ...
Romy van der Groef,Sophie Veldhuijzen van Zanten,Denise van Beekveld et al.
Romy van der Groef et al.
Objective: Pasireotide LAR, a long-acting somatostatin receptor ligand, has shown potential antitumour activity in somatotroph pituitary tumours, as indicated by increased T2-signal intensity on MRI. However, long-term fo...
New routes to the neuroendocrine hypothalamus: the extracellular space [0.03%]
全新的神经内分泌下丘脑通路：细胞外空间通道
Jean Charles Nicolas,Sabrina J P Huwart,Dorothea Ziemens et al.
Jean Charles Nicolas et al.
The neuroendocrine hypothalamus integrates peripheral nutritional and hormonal cues to regulate essential physiological processes, including appetite, metabolism and reproduction. While the mechanisms by which hormones traverse the blood-br...
Use of skeletal muscle fiber composition to assess relationship between amino acid metabolism and insulin sensitivity [0.03%]
利用肌纤维组成评估氨基酸代谢与胰岛素敏感性的关系
Tova Eurén Magnusson,Sarah J Blackwood,Dominik Tischer et al.
Tova Eurén Magnusson et al.
Objective: Here we use skeletal muscle fiber composition to investigate whether defects in amino acid metabolism are involved in the early development of IR in healthy young individuals before onset of clinical manifestat...
World first hybrid neuroendocrine cell line sharing properties of NET G3 and dedifferentiated NEC [0.03%]
世界首个混合神经内分泌细胞系具有NET G3和去分化NEC的特性
Dorothee Rogoll,Laura-Sophie Landwehr,Jochen Schreiner et al.
Dorothee Rogoll et al.
Background: Current therapies for neuroendocrine neoplasms (NENs) are limited, especially for fast-growing dedifferentiated NECs, which exhibit low somatostatin receptor (SSTR) expression and poor prognosis. Well-differen...
A preliminary model to tailor osilodrostat in patients with ACTH-dependent Cushing's syndrome [0.03%]
柳西ドロスタットをACTH依存性クッシング症候群の患者さんに合わせて調製するための仮モデル
Cecilia Piazzola,Frederic Castinetti,Katharina von Fabeck et al.
Cecilia Piazzola et al.
Over the past 10 years, osilodrostat has become one of the most commonly used steroidogenesis inhibitors in Cushing's syndrome. The starting dose is usually determined based on the product characteristics, the prescriber's experience, and c...
Simone Kiel,Till Ittermann,Jean-François Chenot et al.
Simone Kiel et al.