Clinical and Biochemical Characteristics of Patients with Somatic HRAS-mutant Pheochromocytoma and Paraganglioma [0.03%]
HRAS基因突变型嗜铬细胞瘤及副神经瘤患者的临床和生化特征分析
Kun Wang,Zhi Li,Jing Zhang et al.
Kun Wang et al.
Objective: The frequency of pathogenic variants (PVs) in HRAS in Caucasian populations with pheochromocytoma and paraganglioma (PPGL) is significantly lower than that in Chinese, which reflects the ethnic difference in ge...
Hypoxia signaling pathway activation in osteoblasts suppresses osteocalcin production but does not alter male fertility in mice [0.03%]
小鼠成骨细胞活化缺氧信号通路可抑制骨钙素产生但不影响雄性生育能力
Seppe Melis,Naomi Dirckx,Karen De Samblancx et al.
Seppe Melis et al.
Introduction/objective: Bone can contribute to systemic and extra-skeletal processes through bone-derived hormones. The osteoblast-specific protein osteocalcin (OCN) has been reported to positively regulate male fertility...
The effects of acute and chronic exercise on lipocalin-2 in middle-aged and older adults: a randomised control trial [0.03%]
急性及长期运动对中老年人脂连蛋白2的影响——随机对照试验
Carlie Bauer,Marc Sim,Cassandra Smith et al.
Carlie Bauer et al.
Objective: Chronically elevated circulating lipocalin-2 (LCN2) levels are implicated in poor energy regulation, increased cardiometabolic disease risk and poor physical function. Exercise is known to improve these factors...
Empirical hormonal treatments for idiopathic male infertility: a network meta-analysis comparing antiestrogens and FSH [0.03%]
男性特发性不育症的激素治疗方法：网络meta分析比较抗雌激素和促卵泡激素疗法的效果
Daniele Santi,Francesco Pallotti,Daniele Tienforti et al.
Daniele Santi et al.
Background: Idiopathic male infertility, characterized by impaired spermatogenesis without identifiable etiology, lacks targeted therapeutic strategies. Empirical hormonal treatments such as aromatase inhibitors (AIs), se...
Comparative Study
European journal of endocrinology. 2025 Nov 26;193(6):S95-S105. DOI:10.1093/ejendo/lvaf246 2025
New directions in MEN1 management: navigating the new clinical practice guidelines [0.03%]
MEN1管理的新方向：解读新的临床实践指南
Olga Papalou,Márta Korbonits
Olga Papalou
Multiple endocrine neoplasia type 1 (MEN1) remains a clinically challenging syndrome due to its genetic heterogeneity, variable penetrance, and lifelong surveillance needs. The newly published 2025 MEN1 guidelines introduce important refine...
International Consensus on the Requirements for Definitions of Complete Remission and Recurrence of Differentiated Thyroid Cancer: a Delphi Study (ICON-DTC) [0.03%]
国际共识意见：分化型甲状腺癌完全缓解和复发定义的要求（ICON-DTC）德尔菲调查研究结果
Daniël J van de Berg,Hanneke M van Santen,Sarah C Clement et al.
Daniël J van de Berg et al.
Objective: Recurrence is a key outcome measure of treatment for differentiated thyroid carcinoma (DTC). In international guidelines and current literature, a consistent definition is lacking, which hinders comparison of t...
GH replacement therapy in adults stimulates Fibroblast Activation Protein-α activity [0.03%]
生长激素替代疗法可激活成人纤维活化蛋白-α
Amanda Bæk,Anne Kathrine Nissen Pedersen,Tine Borum Billeskov et al.
Amanda Bæk et al.
Background: Growth hormone (GH) potently stimulates collagen turnover which underlies its anabolic effects on bone in children, whereas it may promote fibrosis in adults. Fibroblast activation protein-α (FAPα) is a seri...
Plasma osmolality affects ACTH and cortisol regulation besides magnocellular vasopressin [0.03%]
高渗盐水对血管加压素巨细胞外的ACTH和皮质醇的调节的影响
Lucila L K Elias,Paula C L Elias,José Antunes-Rodrigues et al.
Lucila L K Elias et al.
The recently published article entitled "Disrupted ACTH and cortisol response to osmotic and non-osmotic stress in patients with arginine vasopressin deficiency," authored by Nikaj et al. evaluated the HPA axis response to osmotic and non-o...
Normalization of hyponatremia in hospitalized patients decreases osteoclast activity [0.03%]
通过规范住院患者的低钠血症治疗降低破骨细胞活性
Laura Potasso,Julie Refardt,Sophie Monnerat et al.
Laura Potasso et al.
Objective: Hyponatremia, the most common electrolyte disorder in hospitalized patients, has been largely associated with increased risk of osteoporosis. Preclinical studies suggest that hyponatremia stimulates osteoclast ...
Laura Potasso,Mirjam Christ-Crain,Julie Refardt
Laura Potasso
Hyponatremia is one of the most common electrolyte disorders encountering both in hospitalized and in outpatients. Across the past decades, several cross-sectional and observational studies have shown a strong association between low serum ...