Biochemical control in young women with congenital adrenal hyperplasia taking oral contraceptives: a prospective observational study [0.03%]
口服避孕药对先天性肾上腺增生年轻女性的生化控制影响：一项前瞻性观察研究
Chrysanthi Kouri,Grit Sommer,Fernanda Cavalieri Costa et al.
Chrysanthi Kouri et al.
Objective: Androgen excess in 21-hydroxylase deficiency (21OHD) remains difficult to manage in adolescent females. Combined oral contraceptive(s) (OC) containing ethinylestradiol and progestin modulate ovarian and adrenal...
Observational Study
European journal of endocrinology. 2026 Aug 28;195(3):385-395. DOI:10.1093/ejendo/lvag160 2026
The Link Between Acromegaly, Liver Morphology, and MASLD: A Large Cohort Analysis [0.03%]
肢端肥大症与肝脏形态和MASLD之间的联系：一项大规模队列研究分析
Polat Ercan,Busra Firlatan Yazgan,Suleyman Nahit Sendur et al.
Polat Ercan et al.
Objective: To evaluate liver morphology and clinical determinants in acromegaly. Design: Retrospective single-center cohort study. ...
SGLT-2 inhibitors and risk of 59 long-term health conditions, hospitalization, and mortality [0.03%]
钠葡萄糖协同转运蛋白-2抑制剂与长期健康状况、住院和死亡率的风险关系
Jingya Wang,Jennifer Cooper,Eleanor Hathaway et al.
Jingya Wang et al.
Background: Type 2 diabetes mellitus (T2DM) is often the first condition on the pathway to patients developing multiple long-term conditions (MLTCs). The impact of sodium-glucose cotransporter 2 inhibitors (SGLT-2i), a ke...
Active vitamin D protects against osteoporosis by promoting VDR-dependent CDK2 transcription and P27 degradation [0.03%]
活性维生素D通过促进VDR依赖的CDK2转录和促进P27的降解来预防骨质疏松症
Fangrong Xu,Quan Liu,Mingxin Huang et al.
Fangrong Xu et al.
Objective: Osteoporosis is associated with reduced active vitamin D, but the molecular basis remains incompletely understood. This study investigated how active vitamin D preserves skeletal homeostasis and prevents bone l...
Impact of Oral Contraceptives and Metformin on Advanced Lipid Phenotyping in PCOS [0.03%]
口服避孕药和二甲双胍对多囊卵巢综合征患者血脂谱的影响
Iris T Lee,Daniel E Soffer,Alan T Remaley et al.
Iris T Lee et al.
Context: Combined oral contraceptives (OCPs) and metformin are commonly used in patients with polycystic ovary syndrome (PCOS), who are at elevated risk of dyslipidemia and cardiovascular disease (CVD), but their effects ...
Impact of oral contraceptives and metformin on advanced lipid phenotyping in polycystic ovary syndrome [0.03%]
口服避孕药和二甲双胍对多囊卵巢综合征患者血脂表型的影响
Iris T Lee,Daniel E Soffer,Alan T Remaley et al.
Iris T Lee et al.
Context: Combined oral contraceptives (OCPs) and metformin are commonly used in patients with polycystic ovary syndrome (PCOS), who are at elevated risk of dyslipidemia and cardiovascular disease (CVD), but their effects ...
Randomized Controlled Trial
European journal of endocrinology. 2026 Aug 3;195(2):302-311. DOI:10.1093/ejendo/lvag149 2026
Pan-CDK and PLK1 inhibitors as a novel approach for targeted treatment of adrenocortical carcinomas [0.03%]
针对肾上腺皮质癌靶向治疗的泛CDK和PLK1抑制剂的新方法
Emanuela Esposito,Emma Nozza,Anna Maria Barbieri et al.
Emanuela Esposito et al.
Background Adrenocortical carcinomas (ACC) are aggressive cancers with limited therapeutic options. Cyclin-dependent kinases (CDKs) 1/2/4 and polo-like kinase 1 (PLK1) are upregulated in ACC, suggesting their role as potential targets. Obje...
A Randomized First-in-human Study of a Novel Growth Hormone Receptor Peptide Antagonist ALXN2420 in Healthy Subjects [0.03%]
一种新型生长激素受体肽拮抗剂ALXN2420在健康志愿者中的随机首次人体研究
Soraya Allas,Guillaume Ravel,Colm Farrell et al.
Soraya Allas et al.
Context: Acromegaly is a rare disease typically caused by a growth hormone (GH) secreting pituitary adenoma. Somatostatin receptor ligand (SRL) monotherapy does not provide optimal control of circulating insulin-like grow...
Bone health in complete androgen insensitivity syndrome: a comprehensive assessment in a large adult cohort [0.03%]
完全雄激素不敏感综合征的骨骼健康状况：一大型成人队列的全面评估
Eriselda Profka,Alessandra Mangone,Laura Cocchi et al.
Eriselda Profka et al.
Objective: Low bone mineral density (BMD) has been reported in individuals with complete androgen insensitivity syndrome (CAIS), but data on bone health, particularly on morphometric fractures, remain limited and heteroge...