Somapacitan in children born small for gestational age: a randomized controlled phase 3 trial [0.03%]
一项关于小胎龄儿的随机对照三期试验：索马帕西坦的效果
Agnès Linglart,Volker Böttcher,Michael Højby et al.
Agnès Linglart et al.
Objective: Short stature in children born small for gestational age (SGA) is treated with daily injections of recombinant growth hormone (GH), a significant treatment burden. The objective of this study is to demonstrate ...
Once-weekly Somapacitan in Children with Noonan Syndrome: Randomised Controlled Phase 3 Trial [0.03%]
诺伦综合征患儿接受索马匹单抗每周一次给药的随机对照III期试验
Alexander A L Jorge,Assunta Albanese,Michael Højby et al.
Alexander A L Jorge et al.
Objective: Daily growth hormone (GH) injections are indicated for the treatment of short stature in children with Noonan syndrome, which presents a treatment burden for the child and their parents/caregivers. Somapacitan ...
Clinical performance of an IGF1 LC-MS/MS assay and associated normative dataset in routine endocrinology [0.03%]
一种IGF1液相串联质谱检测在内分泌临床检验中的性能及参考区间的建立研究
Michel J Vos,Mark R Postma,Eef G Lentjes et al.
Michel J Vos et al.
Background: Accurate interpretation of IGF1 requires both analytically robust measurement and appropriate reference data. Most available IGF1 normative datasets are based on ligand-binding assays (LBA), limiting their app...
Combined effect of MASLD and low muscle strength on the risk of osteoporotic fractures: A UK Biobank cohort study [0.03%]
MASLD合并低肌量对骨质疏松性骨折风险的影响：一项英国生物样本库队列研究
Yongin Cho,Jong Hyun Jhee,Jong Ho Jhee et al.
Yongin Cho et al.
Background: The relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporotic fractures risk remains controversial. Low muscle strength (LMS), a key component of sarcopenia and an ...
Subtype- and treatment-based analysis of calcium dynamics in primary aldosteronism [0.03%]
原发性醛固酮增多症的亚型和治疗基线的钙动力学分析
Toshifumi Nakamura,Isao Kurihara,Yosuke Mizutani et al.
Toshifumi Nakamura et al.
Objective: Primary aldosteronism (PA) adversely affects cardiovascular and renal health and has been linked to increased urinary calcium excretion, elevated parathyroid hormone (PTH) levels, and reduced bone mineral densi...
Response to the comments on normalization of hyponatremia in hospitalized patients decreases osteoclast activity [0.03%]
针对“正钠血症的住院患者规范化治疗减少破骨细胞活性”的评论回复
Laura Potasso,Julie Refardt,Sophie Monnerat et al.
Laura Potasso et al.
IGF-PAPP-A-Stanniocalcin Axis and Androgenic Anabolic Steroid Use in Men and Women [0.03%]
男性和女性中的胰岛素样生长因子结合蛋白酶PAPP-A和stanniocalcin轴与雄激素使用的关系
Laust Frisenberg Buhl,Louise Lehmann Christensen,Yeliz Bulut et al.
Laust Frisenberg Buhl et al.
Objective: Anabolic androgenic steroids (AAS) may exert effects through the insulin-like growth factor (IGF) system. We compared the IGF system in male and female recreational athletes who were current or former AAS users...
Somapacitan in children with idiopathic short stature: a randomised controlled phase 3 study [0.03%]
司美帕坎坦治疗不明原因矮小症儿童的三期随机对照研究
M Jennifer Abuzzahab,Andrew Dauber,Michael Højby et al.
M Jennifer Abuzzahab et al.
Objective: Daily growth hormone (GH) injections restore normal growth and improve psychological outcomes in children with idiopathic short stature (ISS) but treatment burden is significant. The objective of this study is ...
Determinants of extracellular fluid calcium concentration in patients with chronic hypoparathyroidism [0.03%]
慢性低甲状旁腺素血症患者细胞外液钙浓度的影响因素分析
Arthur Michon-Colin,Théau Blanchard,Elise Bouderlique et al.
Arthur Michon-Colin et al.
Objective: To assess, in patients with chronic hypoparathyroidism, the relative contribution to serum calcium value of intestinal calcium absorption, renal tubular calcium reabsorption, and net bone calcium release, alter...
Exome Findings in Children with Short Stature Evaluated by Growth Hormone Stimulation Testing [0.03%]
生长激素刺激试验评估的身材矮小儿童的外显子组发现
Idoia Martinez de Lapiscina,Matthias Zürcher,Tanja Zingg et al.
Idoia Martinez de Lapiscina et al.
Objective: Short stature is the most common reason for referral to pediatric endocrinology. Diagnosis primarily relies on history, physical exam and auxological assessment. Although growth hormone (GH) stimulation tests (...