Re-evaluating GLP-1 receptor agonist-associated changes in copeptin [0.03%]
GLP-1受体激动剂相关copeptin变化的再评价
Chengli Jiang,Gang Tian
Chengli Jiang
Risk of bone overstimulation in long-term PTH(1-34) therapy for hypoparathyroidism [0.03%]
长期使用PTH(1-34)治疗低甲状旁腺素血症会导致骨过度刺激的风险
Rebecca Fischler,Anne-Lise Lecoq,Pascal Houillier et al.
Rebecca Fischler et al.
Objective: PTH(1-34), used off-label, effectively controls serum calcium in patients with chronic hypoparathyroidism inadequately managed by standard-of-care therapy. PTH(1-34) also strongly stimulates bone remodeling and...
Observational Study
European journal of endocrinology. 2026 Apr 6;194(4):500-509. DOI:10.1093/ejendo/lvag053 2026
Severe osteogenesis imperfecta due to homozygous glycine substitutions in COL1A1 and COL1A2 [0.03%]
COL1A1和COL1A2中的同型甘氨酸替代导致的严重成骨不全症
Alexandra Blaschitz,Rodrigo Montero-Lopez,Tamer A El-Sobky et al.
Alexandra Blaschitz et al.
Background: Osteogenesis imperfecta (OI) is a rare monogenic bone fragility disorder most often caused by heterozygous pathogenic variants in COL1A1 and COL1A2, typically showing autosomal dominant inheritance. Biallelic ...
Impaired insulin signaling limits osteogenic potential of bone marrow stromal cells in type 2 diabetes [0.03%]
胰岛素信号受损限制了2型糖尿病骨髓基质细胞的成骨潜能
Nina Wærling Hansen,Atenisa Caci,Eva Maria Wölfel et al.
Nina Wærling Hansen et al.
Objective: Type 2 diabetes (T2D) is associated with low bone turnover and increased fracture risk. Although impaired insulin signaling is a hallmark of T2D in classical metabolic tissues, it remains unclear whether simila...
Observational Study
European journal of endocrinology. 2026 Apr 6;194(4):527-543. DOI:10.1093/ejendo/lvag063 2026
DXA-measured truncal adiposity in adolescence but not in childhood longitudinally predicts worsening cardiac outcomes [0.03%]
青少年而非儿童期DEXA测量的躯干脂肪纵向预测心脏预后恶化
Andrew O Agbaje
Andrew O Agbaje
Background: Longitudinal evidence on the dual-energy X-ray absorptiometry measures of body composition from childhood with changes in cardiac structure and function in youth is scarce. ...
Laura Gerard,Charlotte Juin,Marine Perrier et al.
Laura Gerard et al.
Objective: The rising incidence of neuroendocrine tumors (NETs) and delayed motherhood raise concerns about pregnancy outcomes and management, yet data remain scarce. ...
Jie Liu,Xiang Zhou,Huijuan Zhu et al.
Jie Liu et al.
Objective: ACTH-dependent Cushing's syndrome (CS) causes profound immune dysfunction and severe infections. This study aimed to characterize immune cell phenotypes, develop predictive models for differentiating Cushing's ...
Novel HK1 intronic variant in congenital hyperinsulinism: impaired transactivation function for FOXA2 [0.03%]
FOXA2转录激活功能受损导致的新生HK1内含子变异与先天性高胰岛素血症有关
Kaori Yamoto,Sachiko Miyamoto,Shinichiro Sano et al.
Kaori Yamoto et al.
Recent studies have revealed multiple genetic variants affecting a highly conserved ∼50 bp region encompassing the putative NFAT-, NKX2-, and FOX-binding sites in HK1 intron 2 in congenital hyperinsulinism (CHI) with aberrant HK1 expressio...
Regional adrenalectomy completed by prophylactic hyperthermic intraperitoneal chemotherapy reduces the incidence of local and peritoneal recurrence after curative surgery for adrenocortical carcinoma [0.03%]
区域肾上腺切除术后，预防性腹腔内高温化疗可降低治愈术后局部和腹膜复发的发病率
Guido Alberto Massimo Tiberio,Giovanni Casole,Deborah Cosentini et al.
Guido Alberto Massimo Tiberio et al.
Background: Local and peritoneal recurrence (L/PR) after curative surgery for adrenocortical carcinoma has a high incidence and negatively affects the clinical course of the disease. We retrospectively reviewed our databa...
Incidence and hospital outcomes of acute adrenal crisis in a Swiss-wide cohort study [0.03%]
瑞士全国队列急性肾上腺危象发病率和住院结局分析研究
Sandra Gafner,Katja Leitner,Philipp Schuetz et al.
Sandra Gafner et al.
Background: Adrenal crises (AC) are life-threatening emergencies for which epidemiological data remain scarce, particularly in older adults. We analyzed nationwide data on AC-related hospitalizations in Switzerland betwee...