Empirical hormonal treatments for idiopathic male infertility: a network meta-analysis comparing antiestrogens and FSH [0.03%]
男性特发性不育症的激素治疗方法：网络meta分析比较抗雌激素和促卵泡激素疗法的效果
Daniele Santi,Francesco Pallotti,Daniele Tienforti et al.
Daniele Santi et al.
Background: Idiopathic male infertility, characterized by impaired spermatogenesis without identifiable etiology, lacks targeted therapeutic strategies. Empirical hormonal treatments such as aromatase inhibitors (AIs), se...
Comparative Study
European journal of endocrinology. 2025 Nov 26;193(6):S95-S105. DOI:10.1093/ejendo/lvaf246 2025
New directions in MEN1 management: navigating the new clinical practice guidelines [0.03%]
MEN1管理的新方向：解读新的临床实践指南
Olga Papalou,Márta Korbonits
Olga Papalou
Multiple endocrine neoplasia type 1 (MEN1) remains a clinically challenging syndrome due to its genetic heterogeneity, variable penetrance, and lifelong surveillance needs. The newly published 2025 MEN1 guidelines introduce important refine...
International Consensus on the Requirements for Definitions of Complete Remission and Recurrence of Differentiated Thyroid Cancer: a Delphi Study (ICON-DTC) [0.03%]
国际共识意见：分化型甲状腺癌完全缓解和复发定义的要求（ICON-DTC）德尔菲调查研究结果
Daniël J van de Berg,Hanneke M van Santen,Sarah C Clement et al.
Daniël J van de Berg et al.
Objective: Recurrence is a key outcome measure of treatment for differentiated thyroid carcinoma (DTC). In international guidelines and current literature, a consistent definition is lacking, which hinders comparison of t...
GH replacement therapy in adults stimulates Fibroblast Activation Protein-α activity [0.03%]
生长激素替代疗法可激活成人纤维活化蛋白-α
Amanda Bæk,Anne Kathrine Nissen Pedersen,Tine Borum Billeskov et al.
Amanda Bæk et al.
Background: Growth hormone (GH) potently stimulates collagen turnover which underlies its anabolic effects on bone in children, whereas it may promote fibrosis in adults. Fibroblast activation protein-α (FAPα) is a seri...
Plasma osmolality affects ACTH and cortisol regulation besides magnocellular vasopressin [0.03%]
高渗盐水对血管加压素巨细胞外的ACTH和皮质醇的调节的影响
Lucila L K Elias,Paula C L Elias,José Antunes-Rodrigues et al.
Lucila L K Elias et al.
The recently published article entitled "Disrupted ACTH and cortisol response to osmotic and non-osmotic stress in patients with arginine vasopressin deficiency," authored by Nikaj et al. evaluated the HPA axis response to osmotic and non-o...
Normalization of hyponatremia in hospitalized patients decreases osteoclast activity [0.03%]
通过规范住院患者的低钠血症治疗降低破骨细胞活性
Laura Potasso,Julie Refardt,Sophie Monnerat et al.
Laura Potasso et al.
Objective: Hyponatremia, the most common electrolyte disorder in hospitalized patients, has been largely associated with increased risk of osteoporosis. Preclinical studies suggest that hyponatremia stimulates osteoclast ...
Laura Potasso,Mirjam Christ-Crain,Julie Refardt
Laura Potasso
Hyponatremia is one of the most common electrolyte disorders encountering both in hospitalized and in outpatients. Across the past decades, several cross-sectional and observational studies have shown a strong association between low serum ...
Integrating Histology and Biomarkers to Predict Clinical Outcomes in Parathyroid Tumors: A Multicenter Study [0.03%]
整合组织学和生物标志物预测甲状旁腺肿瘤临床结局的多中心研究
Pablo Rodríguez de Vera Gómez,Jesús Machuca Aguado,Beatriz Rodríguez-Jiménez et al.
Pablo Rodríguez de Vera Gómez et al.
Aim: To evaluate clinical, biochemical, and histopathological determinants of disease severity and postoperative outcomes in parathyroid tumors, and to assess whether a composite histology-biomarker Risk Score provides an...
Response to Dr. Sarah C.J. Jorgensen's letter: Addressing Immortal Time Bias and Methodological Concerns in Testosterone Therapy Research [0.03%]
对Sarah C.J. Jorgensen博士来信的回复：解决睾酮治疗研究中的永生时间偏倚及方法学问题
Fabrice Bonnet,Laurent Fauchier
Fabrice Bonnet
European clinical guidance for the management of adrenal and extra-adrenal paraganglioma in children and adolescents: a consensus by the EXPeRT group [0.03%]
儿童和青少年肾上腺及肾上腺外副神经瘤的欧洲临床诊疗指南：EXPeRT组专家共识
Michaela Kuhlen,Calogero Virgone,Charlotte Rigaud et al.
Michaela Kuhlen et al.
Background: Adrenal (formerly termed pheochromocytomas) and extra-adrenal paragangliomas (PGLs) in children and adolescents are rare neuroendocrine tumours characterized by unique biological behaviour, a strong hereditary...