PRKACA constitutional duplication: a specific cause of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) [0.03%]
PRKACA基因复制是原发性色素结节性肾上腺皮质病的特异性病因
Patricia Vaduva,Florian Violon,Albain Chansavang et al.
Patricia Vaduva et al.
Objective: Constitutional duplications of PRKACA (PRKACAdup) have been described in rare cases of bilateral nodular adrenocortical disease (BNAD). The aim here was to clarify the phenotype in case of PRKACAdup, through sy...
Recurrent CACNA1HE282K is a gain of function mutation associated with primary hyperaldosteronism [0.03%]
CACNA1H E282K复发突变与特发性原发性醛固酮增多症相关并为功能获得型mutation
Ruyi Li,Yiran Jiang,Qiujing Chen et al.
Ruyi Li et al.
Context: Germline CACNA1H mutations have been associated with primary aldosteronism (PA). Here we described three newly discovered CACNA1H variants and explored the possible pathogenic mechanisms as well as therapeutic st...
Hypoxia, iron, and ferroptosis: a novel perspective on pheochromocytoma progression and therapy [0.03%]
缺氧、铁和铁死亡：嗜铬细胞瘤进展与治疗的新视角
Yutaro Ruike,Sawako Suzuki,Rei Hashimoto et al.
Yutaro Ruike et al.
Objectives: All pheochromocytomas (PCCs) have metastatic potential, and inoperable cases often resist multidisciplinary treatment. Pheochromocytomas are broadly divided into cluster 1 (hypoxia signaling) and cluster 2 (ki...
Mingyan Jiang,Ulrich Stifel,Matthias Blüher et al.
Mingyan Jiang et al.
Adipose tissue closely interacts with the adrenal glands to regulate metabolism, energy balance and stress responses. While the adrenal cortex secretes glucocorticoids and mineralocorticoids that influence adipose tissue distribution, lipid...
Clinical and Biochemical Characteristics of Patients with Somatic HRAS-mutant Pheochromocytoma and Paraganglioma [0.03%]
HRAS基因突变型嗜铬细胞瘤及副神经瘤患者的临床和生化特征分析
Kun Wang,Zhi Li,Jing Zhang et al.
Kun Wang et al.
Objective: The frequency of pathogenic variants (PVs) in HRAS in Caucasian populations with pheochromocytoma and paraganglioma (PPGL) is significantly lower than that in Chinese, which reflects the ethnic difference in ge...
Hypoxia signaling pathway activation in osteoblasts suppresses osteocalcin production but does not alter male fertility in mice [0.03%]
小鼠成骨细胞活化缺氧信号通路可抑制骨钙素产生但不影响雄性生育能力
Seppe Melis,Naomi Dirckx,Karen De Samblancx et al.
Seppe Melis et al.
Introduction/objective: Bone can contribute to systemic and extra-skeletal processes through bone-derived hormones. The osteoblast-specific protein osteocalcin (OCN) has been reported to positively regulate male fertility...
The effects of acute and chronic exercise on lipocalin-2 in middle-aged and older adults: a randomised control trial [0.03%]
急性及长期运动对中老年人脂连蛋白2的影响——随机对照试验
Carlie Bauer,Marc Sim,Cassandra Smith et al.
Carlie Bauer et al.
Objective: Chronically elevated circulating lipocalin-2 (LCN2) levels are implicated in poor energy regulation, increased cardiometabolic disease risk and poor physical function. Exercise is known to improve these factors...
Empirical hormonal treatments for idiopathic male infertility: a network meta-analysis comparing antiestrogens and FSH [0.03%]
男性特发性不育症的激素治疗方法：网络meta分析比较抗雌激素和促卵泡激素疗法的效果
Daniele Santi,Francesco Pallotti,Daniele Tienforti et al.
Daniele Santi et al.
Background: Idiopathic male infertility, characterized by impaired spermatogenesis without identifiable etiology, lacks targeted therapeutic strategies. Empirical hormonal treatments such as aromatase inhibitors (AIs), se...
Comparative Study
European journal of endocrinology. 2025 Nov 26;193(6):S95-S105. DOI:10.1093/ejendo/lvaf246 2025
New directions in MEN1 management: navigating the new clinical practice guidelines [0.03%]
MEN1管理的新方向：解读新的临床实践指南
Olga Papalou,Márta Korbonits
Olga Papalou
Multiple endocrine neoplasia type 1 (MEN1) remains a clinically challenging syndrome due to its genetic heterogeneity, variable penetrance, and lifelong surveillance needs. The newly published 2025 MEN1 guidelines introduce important refine...
International Consensus on the Requirements for Definitions of Complete Remission and Recurrence of Differentiated Thyroid Cancer: a Delphi Study (ICON-DTC) [0.03%]
国际共识意见：分化型甲状腺癌完全缓解和复发定义的要求（ICON-DTC）德尔菲调查研究结果
Daniël J van de Berg,Hanneke M van Santen,Sarah C Clement et al.
Daniël J van de Berg et al.
Objective: Recurrence is a key outcome measure of treatment for differentiated thyroid carcinoma (DTC). In international guidelines and current literature, a consistent definition is lacking, which hinders comparison of t...