BAMBI acts as a molecular switch to determine cell fate of C2C12 myoblasts [0.03%]
BAMBI充当分子开关以决定C2C12肌管细胞命运
Xiangping Yao,Liwei Xie
Xiangping Yao
Myogenesis is a tightly regulated process by a cascade of well-coordinated events and pathways. Other than the known myogenic regulator factor (MRF) family including Myf5, MyoD, Myogenin and MRF4, our previous study identified BAMBI is invo...
Toxic Crossroads: Environmental Pesticides and their Endocrine Footprints in Global Metabolic Health [0.03%]
毒物十字路口：全球代谢健康中的环境农药及其内分泌足迹
Sunday Amos Onikanni,Marjorie Dardis Murucci,Talis Gonçalves da Costa et al.
Sunday Amos Onikanni et al.
Endocrine-disrupting pesticides (EDPs) exert deleterious effects on the endocrine system, with documented evidence implicating specific pesticides in endocrine disruption, resulting in developmental delays during puberty and thyroid gland d...
Chloride-permeable channels in white adipocytes: their role in adipogenesis and membrane potential [0.03%]
白色脂肪细胞中的氯离子通透性通道及其在膜电位和脂肪发生中的作用
Yan Meng,Paul A Smith
Yan Meng
Ion fluxes, regulated by membrane potential (Vm), are vital to white fat adipocyte (WFA) function and adipogenesis. These processes present a novel target to intervene in obesity. To explore this possibility we applied transcriptomics, immu...
A literature overview of age- and Tanner stage-specific reference intervals for sex hormones for children aged 0 - 18 years [0.03%]
儿童性激素年龄和坦纳分期特异参考区间的文献综述（0-18岁）
Anouk Olthof,Anita Boelen,Jacquelien J Hillebrand et al.
Anouk Olthof et al.
Study objective: This study aims to provide a comprehensive overview of age- and Tanner stage-specific reference intervals (RIs) for testosterone, estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), a...
Diabetes compromises DNA damage repair and telomere maintenance in adipose tissue stromal cells leading to cellular senescence [0.03%]
糖尿病通过损害脂肪组织间充质干细胞中的DNA修复和端粒维持功能而导致细胞衰老
Saiuree Govender,Kelly S Petersen-Ross,Carola U Niesler et al.
Saiuree Govender et al.
Diabetes mellitus (DM) is characterized by chronic metabolic stress that promotes oxidative damage, genomic instability, and premature cellular aging, with adipose tissue senescence being a pivotal contributor to metabolic dysfunction. Yet ...
Vagal and splenic influences on hepcidin-iron homeostasis of lean and hypothalamic obese male rats after anemia induction [0.03%]
迷走神经和脾脏对雄性轻度和下丘脑肥胖大鼠缺铁诱导后肝肽-铁稳态的影响
Ellen Carolina Zawoski Gomes,Amanda Rocha Fujita,Marianela Díaz Urrutia et al.
Ellen Carolina Zawoski Gomes et al.
The vagus nerve (VN) and spleen are involved in the anti-inflammatory vagal reflex, which influences the metabolic state, with unknown effects on iron metabolism. Here, we evaluate the impact of subdiaphragmatic vagotomy (SV) and splenectom...
ROS-driven mitochondrial and mtDNA release as a novel pathway of metabolic injury in diabetes [0.03%]
ROS诱导的线粒体和mtDNA释放是糖尿病中代谢损伤的新途径
Dandan Chen,Yuxin Jia,Xiaohong Duan et al.
Dandan Chen et al.
Mitochondrial dysfunction driven by chronic hyperglycemia is a hallmark of diabetes, yet how this metabolic stress communicates pathological signals beyond individual cells remains poorly understood. In this study, we identified a novel mec...
CRISPR activation of DLX5 drives neural progenitors to the GnRH cell fate [0.03%]
CRISPR激活DLX5驱动神经祖细胞走向GnRH细胞命运
Shrinidhi Madhusudan,Nazli Eskici,Celia Gomez-Sanchez et al.
Shrinidhi Madhusudan et al.
Gonadotropin-releasing hormone (GnRH) neurons regulate the hypothalamic-pituitary-gonadal (HPG) axis and are required for puberty onset and reproductive competence. However, the transcriptional regulators governing GnRH neuron specification...
Novel gain-of-function CLCN2 germline mutation associated with nonclassical lateralizing primary aldosteronism [0.03%]
新型CLCN2生殖细胞增益功能突变与非经典的醛固酮瘤相关性偏向性症状关联的研究
Ssu-Ju Fu,Kang-Yung Peng,Ya-Hui Hu et al.
Ssu-Ju Fu et al.
Primary aldosteronism (PA) is commonly caused by somatic and germline mutations in various genes. Patients with unilateral PA may display classical or nonclassical histopathologic features in adrenal tumors. Somatic and germline mutations a...
A Computational Systems Biology View on the Role of the Menstrual Cycle in Endocrine Health and Disease [0.03%]
计算系统生物学在月经周期的内分泌健康和疾病中的作用分析
Susanna Röblitz
Susanna Röblitz
In the era of personalized and precision medicine, sex is an important biological variable that needs to be taken into account in biomedical research. However, the role of the menstrual cycle has long been neglected because it requires clin...