Profiling of Plasma Extracellular Vesicles miRNA Reveals the Association of miR-3120-5p with Type 2 Diabetes Mellitus [0.03%]
基于血浆外泌体的miRNA筛选及miR-3120-5p与2型糖尿病关联性研究
Xiaoying Ren,Yuqian Li,Yujie Jiang et al.
Xiaoying Ren et al.
Background: Extracellular vesicles (EVs) miRNAs play pivotal roles in metabolic disorders. This study aimed to describe the plasma EV miRNA profiling of type 2 diabetes mellitus (T2DM) and evaluate the association between...
An ovine model shows that subcutaneous adipose tissue fibrosis occurs early in polycystic ovary syndrome (PCOS) [0.03%]
绵羊模型显示，纤维化在多囊卵巢综合征(subcutaneous adipose tissue)中早期发生(PCOS)
Yuan Wang,Giovanni Levate,Michael T Rae et al.
Yuan Wang et al.
Prenatally androgenised (PA) sheep are a clinically realistic model of polycystic ovary syndrome (PCOS). They have dysfunctional subcutaneous adipose tissue (SAT) with reduced adipogenesis in adolescence and enlarged adipocytes with increas...
Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes [0.03%]
利用增生性或凋亡性药物靶向衰老细胞以影响糖尿病
Mari van de Vyver,Saiuree Govender,Kelly Petersen-Ross et al.
Mari van de Vyver et al.
Type 2 diabetes mellitus (DM) is closely associated with cellular senescence (SnC), a state of irreversible cell cycle arrest marked by functional decline. Preventing cellular senescence in already diagnosed DM patients is crucial for limit...
HNF1α-Q125ter-mediated mitochondrial dysfunction and impaired mitophagy in β-cells [0.03%]
β细胞中由HNF1α-Q125ter介导的线粒体功能障碍和线粒体自噬受损
Fei Jiang,Jie Huang,Xinyan Chen et al.
Fei Jiang et al.
Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes caused by single-gene mutations. MODY3, the most common subtype, results from mutations in the hepatocyte nuclear factor 1-alpha (HNF1α) gene. HNF1α is a transcri...
MicroRNA-411-5p alleviates hepatic insulin resistance via suppressing transcription factor Sp2 in MASLD mice [0.03%]
MicroRNA-411-5p通过抑制转录因子Sp2缓解MASLD小鼠的肝脏胰岛素抵抗
Chunli Song,Jinglin Shao,Qingquan Xiong et al.
Chunli Song et al.
Insulin resistance is often characterized as the factor that contributes to the emergence of metabolic diseases. Hepatic microRNAs (miRNAs) played critical roles in the development of metabolic-associated steatotic liver disease (MASLD) and...
Antioxidant, Bioenergetic, and Metabolic Effects of Novel Mitochondria-Targeted Estrogens [0.03%]
新型线粒体靶向雌激素的抗氧化、生物能量和代谢效应
Geovanni Alberto Ruiz-Romero,Johanna Bernáldez-Sarabia,Magdiel Orozco-Valdivia et al.
Geovanni Alberto Ruiz-Romero et al.
Estrogens are steroid hormones that regulate antioxidant and mitochondrial bioenergetic metabolism in addition to activating nuclear genomic pathways. Concentrating these effects within the mitochondria is a novel strategy for ameliorating ...
Intronic IGF1R Variant Causing Aberrant Splicing, Short Stature and Neurological Impairments [0.03%]
IGF1R内含子变异导致剪接异常、矮小和神经功能障碍
Liya Kerem,Jonathan Rips,Adam Zaretsky et al.
Liya Kerem et al.
ERRATUM: Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells [0.03%]
ERRATUM：胰岛素样生长因子结合蛋白-1对人类乳腺癌细胞整合素信号传导及凋亡诱导的影响
C M Perks,P V Newcomb,M R Norman et al.
C M Perks et al.
Published Erratum
Journal of molecular endocrinology. 2025 Oct 3;75(3):x220141. DOI:10.1530/JME-22-0141e 2025
NR4A3 affects fibrotic activation of orbital fibroblasts and thyroid-associated ophthalmopathy through regulating NF-κB signaling [0.03%]
NR4A3通过调节NF-κB信号影响眼眶成纤维细胞的纤维化活化及甲状腺相关性眼病发生发展的作用及机制研究
Jinping Yi,Shenghua Liu,Shiyao Lu et al.
Jinping Yi et al.
Orbital fibroblast proliferation and activation contribute to the development of thyroid-associated ophthalmopathy (TAO). In this study, nuclear receptor subfamily 4 group A member 3 (NR4A3) was predicted to play a role in TAO based on bioi...
Single cell analysis of uterine artery endothelial cells reveals cytokine induced emergence of specific immunomodulatory subtypes: implications for preeclampsia [0.03%]
单细胞分析发现子宫动脉内皮细胞在细胞因子刺激下产生特定的免疫调节亚型：子痫前期的潜在机制
Dahn Rl,B M Lett,Clemente L et al.
Dahn Rl et al.
While pregnancy is known to be an inflammatory condition, preeclampsia (PE) is associated with higher chemokines and pro-inflammatory cytokines, and higher Th1/Th2 and Th17/Treg ratios. Since the uteroplacental space can secrete cytokines, ...