Linoleic acid reduces Sodium-Iodide Symporter by inhibiting endoplasmic reticulum stress in papillary thyroid carcinoma [0.03%]
油酸通过抑制内质网应激减少乳头状甲状腺癌中的钠碘转运蛋白表达
Nianting Ju,Yumin Liu,Fan Yu et al.
Nianting Ju et al.
Novel biomarkers are imperative for predicting radioactive iodine (RAI) avidity in metastatic lesions of differentiated thyroid carcinoma (DTC), and mechanisms regulating RAI uptake remain incompletely understood. This study aimed to identi...
Therapeutic effect of IL-11 inhibition on the pathogenesis of thyroid eye disease [0.03%]
针对甲状腺相关性眼病发病机制的IL-11抑制治疗效果研究
Hee Joo Yoon,Hyun Young Park,Ji-Young Kim et al.
Hee Joo Yoon et al.
Thyroid eye disease (TED), a major extrathyroidal manifestation of Graves' disease, is driven by the underlying autoimmune responses. This study aimed to elucidate the pathological role of IL-11 in TED and evaluate the therapeutic potential...
Retinoic Acid Receptor β Deletion in Podocytes Causes Kidney and Liver Dysfunction Modeling Nephrotic Syndrome [0.03%]
podocyte 中 Retinoic Acid Receptor β 缺失导致的肾脏和肝脏功能障碍模型化肾病综合征
Yuling Chi,Krysta M DiKun,Xiao-Han Tang et al.
Yuling Chi et al.
Differentially altered expression of transcripts of retinoic acid receptors α, β, γ (Rarα, β, γ), which mediate the actions of all-trans retinoic acid (RA), is observed in glomeruli of nephrotic syndrome (NS) patients vs normal indivi...
Profiling of Plasma Extracellular Vesicles miRNA Reveals the Association of miR-3120-5p with Type 2 Diabetes Mellitus [0.03%]
基于血浆外泌体的miRNA筛选及miR-3120-5p与2型糖尿病关联性研究
Xiaoying Ren,Yuqian Li,Yujie Jiang et al.
Xiaoying Ren et al.
Background: Extracellular vesicles (EVs) miRNAs play pivotal roles in metabolic disorders. This study aimed to describe the plasma EV miRNA profiling of type 2 diabetes mellitus (T2DM) and evaluate the association between...
An ovine model shows that subcutaneous adipose tissue fibrosis occurs early in polycystic ovary syndrome (PCOS) [0.03%]
绵羊模型显示，纤维化在多囊卵巢综合征(subcutaneous adipose tissue)中早期发生(PCOS)
Yuan Wang,Giovanni Levate,Michael T Rae et al.
Yuan Wang et al.
Prenatally androgenised (PA) sheep are a clinically realistic model of polycystic ovary syndrome (PCOS). They have dysfunctional subcutaneous adipose tissue (SAT) with reduced adipogenesis in adolescence and enlarged adipocytes with increas...
Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes [0.03%]
利用增生性或凋亡性药物靶向衰老细胞以影响糖尿病
Mari van de Vyver,Saiuree Govender,Kelly Petersen-Ross et al.
Mari van de Vyver et al.
Type 2 diabetes mellitus (DM) is closely associated with cellular senescence (SnC), a state of irreversible cell cycle arrest marked by functional decline. Preventing cellular senescence in already diagnosed DM patients is crucial for limit...
HNF1α-Q125ter-mediated mitochondrial dysfunction and impaired mitophagy in β-cells [0.03%]
β细胞中由HNF1α-Q125ter介导的线粒体功能障碍和线粒体自噬受损
Fei Jiang,Jie Huang,Xinyan Chen et al.
Fei Jiang et al.
Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes caused by single-gene mutations. MODY3, the most common subtype, results from mutations in the hepatocyte nuclear factor 1-alpha (HNF1α) gene. HNF1α is a transcri...
MicroRNA-411-5p alleviates hepatic insulin resistance via suppressing transcription factor Sp2 in MASLD mice [0.03%]
MicroRNA-411-5p通过抑制转录因子Sp2缓解MASLD小鼠的肝脏胰岛素抵抗
Chunli Song,Jinglin Shao,Qingquan Xiong et al.
Chunli Song et al.
Insulin resistance is often characterized as the factor that contributes to the emergence of metabolic diseases. Hepatic microRNAs (miRNAs) played critical roles in the development of metabolic-associated steatotic liver disease (MASLD) and...
Antioxidant, Bioenergetic, and Metabolic Effects of Novel Mitochondria-Targeted Estrogens [0.03%]
新型线粒体靶向雌激素的抗氧化、生物能量和代谢效应
Geovanni Alberto Ruiz-Romero,Johanna Bernáldez-Sarabia,Magdiel Orozco-Valdivia et al.
Geovanni Alberto Ruiz-Romero et al.
Estrogens are steroid hormones that regulate antioxidant and mitochondrial bioenergetic metabolism in addition to activating nuclear genomic pathways. Concentrating these effects within the mitochondria is a novel strategy for ameliorating ...
Intronic IGF1R Variant Causing Aberrant Splicing, Short Stature and Neurological Impairments [0.03%]
IGF1R内含子变异导致剪接异常、矮小和神经功能障碍
Liya Kerem,Jonathan Rips,Adam Zaretsky et al.
Liya Kerem et al.