Mark B Meyer,J Wesley Pike
Mark B Meyer
The vitamin D receptor (VDR) is a ligand-activated nuclear receptor that mediates the biological actions of vitamin D and is a critical regulator of mineral homeostasis, cellular differentiation, immune function, and metabolism. VDR is a hi...
Attenuation of Diet-Induced Obesity and Impaired Glucose Homeostasis by IL-2/Anti-IL-2 Complex and Hyperbaric Oxygen [0.03%]
白细胞介素2/抗白细胞介素2复合物和高压氧减轻饮食诱导的肥胖和糖代谢紊乱
Eun-Jeong Choi,Hyung-Ran Kim,Jeong-Hae Kie et al.
Eun-Jeong Choi et al.
Obesity is characterized by chronic inflammation and impaired glucose homeostasis. Regulatory T cells (Tregs) preserve immunometabolic balance, and their reduction contributes to metabolic disturbances. Although IL-2/anti-IL-2 complex (IL-2...
Rapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner [0.03%]
氯喹通过依赖ERRα的方式减轻雷帕霉素诱导的小鼠脂肪肝效应
Wafa B&#x;chir,Catherine R Dufour,Sylvia Andrzejewski et al.
Wafa B&#x;chir et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), remains a major health concern world-wide. Hepatic steatosis manifests by the aberrant accumulation of lipids i...
Scutellarin ameliorates PCOS mouse model by restoring mitochondrial function and inhibiting granulosa cell apoptosis [0.03%]
锦灯笼素通过恢复线粒体功能和抑制颗粒细胞凋亡改善PCOS小鼠模型
Zhi Li,Xiaoping Yang,Weifen Deng et al.
Zhi Li et al.
Background: Polycystic ovary syndrome (PCOS), a common endocrine-metabolic disorder, lacks effective therapeutic options. Granulosa cell (GC) apoptosis and mitochondrial dysfunction are critical drivers of ovarian dysfunc...
Renal Vdr deletion drives urinary calcium loss with intestinal and skeletal compensatory responses [0.03%]
肾Vdr缺失通过肠道和骨骼的代偿反应导致尿钙丢失
Lieve Verlinden,Stefanie Doms,Iris Janssens et al.
Lieve Verlinden et al.
1,25-dihydroxyvitamin D3 [1,25(OH)2D3], parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23) are endocrine regulators of calcium homeostasis. To assess the contribution of 1,25(OH)2D3-mediated renal calcium reabsorption to sys...
Ramírez Nicolás David,Schulman Fernández Martín,Torres Pedro Javier et al.
Ramírez Nicolás David et al.
Controlled ovarian hyperstimulation (COH) is essential in assisted reproductive technologies, although some studies have associated it with reduced reproductive success. We recently demonstrated that COH increases circulating ghrelin; howev...
Exendin-4 improves high glucose-induced mitochondrial dysfunction of pancreatic β-cells via PKA/Drp1 signaling [0.03%]
exendin-4通过PKA/Drp1信号改善高糖诱导的胰岛β细胞线粒体功能障碍
Jiahao Zhao,Xin Ling,Siwen Fan et al.
Jiahao Zhao et al.
The development of type 2 diabetes mellitus is closely associated with mitochondrial dysfunction of pancreatic β-cells, but the mechanisms by which glucagon-like peptide-1 receptor activation preserves mitochondrial homeostasis under gluco...
Chronic hyperinsulinemia accelerates adipose senescence via mitochondrial dysfunction and cGAS-STING signalling [0.03%]
慢性高胰岛素血症通过线粒体功能障碍和cGAS-STING信号促进脂肪组织衰老
Astha Singh,Nilesh Khandelwal,Prashant Rai et al.
Astha Singh et al.
Prediabetes and Type 2 Diabetes represent major global health challenges and have escalated to pandemic levels. Adipose tissue functions as a critical endocrine organ, playing a central role in maintaining glucose homeostasis during fasting...
Probiotic Lactobacillus Reuteri KUB-AC5 Provides Cardioprotection via Mitigating Cardiac Mitochondrial Dysfunction in Obese Rats [0.03%]
益生菌乳酸菌罗伊氏杆菌KUB-AC5通过缓解肥胖大鼠心脏线粒体功能障碍提供心脏保护作用
Chanisa Thonusin,Titikorn Chunchai,Parameth Thiennimitr et al.
Chanisa Thonusin et al.
Cardiac mitochondrial dysfunction is a crucial mechanism underlying obesity-induced cardiovascular diseases. A close link between obesity and gut microbiota has been revealed, and the benefits of gut microbiota modulation by probiotics have...
Relationship between hypothalamic astrocytes and gonadotropin-releasing hormone-neurons in the female plains vizcacha [0.03%]
雌性平原大豪猪下丘脑星形胶质细胞与 GnRH-神经元之间的关系
Micaela Inés Llanos Dumont,Alejandro Raúl Schmidt,Ileana Abigail Burd et al.
Micaela Inés Llanos Dumont et al.
Astrocytes play an essential role in the control of gonadotropin-releasing hormone (GnRH) neurons. However, limited information is available in non-conventional animal models. This study aimed to explore hypothalamic astrocyte distribution ...