Kathleen Ka Cho,Mark F Bear
Kathleen Ka Cho
The modification of synapses by neural activity has been proposed to be the substrate for experience-dependent brain development, learning, and recovery of visual function after brain injury. The effectiveness or 'strength' of synaptic tran...
L Christine Turtzo,Louise D McCullough
L Christine Turtzo
Stroke is a sexually dimorphic disease, with differences between males and females observed both clinically and in the laboratory. While males have a higher incidence of stroke throughout much of the lifespan, aged females have a higher bur...
Development of histone deacetylase inhibitors as therapeutics for neurological disease [0.03%]
组蛋白去乙酰化酶抑制剂治疗神经疾病的开发工作
Joel M Gottesfeld,Massimo Pandolfo
Joel M Gottesfeld
Postsynthetic modifications of histone and other chromosomal proteins by reversible acetylation and/or methylation regulate many aspects of chromatin dynamics, such as transcription, replication and DNA repair. Aberrant modification states ...
Rong Chen,Cheryse A Furman,Margaret E Gnegy
Rong Chen
The dopamine transporter (DAT) is a primary determinant of the concentration of dopamine in the synapse and is involved in a number of psychiatric and neurological diseases. The transporter actively takes up its physiological substrate, dop...
Evidence for RNA-mediated toxicity in the fragile X-associated tremor/ataxia syndrome [0.03%]
脆性X染色体相关震颤/共济失调综合征的RNA介导毒性的证据
Jocelyn N Galloway,David L Nelson
Jocelyn N Galloway
Fragile X premutation carriers are at risk for developing a late-onset, progressive neurodegenerative disorder termed fragile X-associated tremor/ataxia syndrome (FXTAS). A growing body of evidence suggests the characteristic excess CGG rep...
Deborah E Barnes,Kristine Yaffe
Deborah E Barnes
There are currently more than 5 million people in the USA living with Alzheimer's disease and other forms of dementia, and prevalence is expected to triple over the next 40 years. As new strategies for prevention and treatment are developed...
Michael Seidenberg,Dalin T Pulsipher,Bruce Hermann
Michael Seidenberg
Comorbid health conditions are common among people with epilepsy. Proposed explanations for this association include the possibility that first, epilepsy (including its treatment) causes the comorbid condition; second, the comorbid conditio...
Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing [0.03%]
听力损失干扰突触抑制：对听觉处理的影响
Anne E Takesian,Vibhakar C Kotak,Dan H Sanes
Anne E Takesian
Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses, which play a fundamental role in all aspec...
Hoby Hetherington
Hoby Hetherington
As the concept of a network of injury has emerged in the treatment of epilepsy, the importance of evaluating that network noninvasively has also grown. Recently, studies utilizing magnetic resonance spectroscopic imaging, manganese-enhanced...
Thomas M Jeitner,Nancy A Muma,Kevin P Battaile et al.
Thomas M Jeitner et al.
The following review examines the role of calcium in promoting the in vitro and in vivo activation of transglutaminases in neurodegenerative disorders. Diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease exhib...