Curt A Sandman,Elysia P Davis
Curt A Sandman
The developmental origins of disease or fetal programming model predicts that early exposures to threat or adverse conditions have lifelong consequences that result in harmful outcomes for health. The vast majority of the studies in support...
Maria Melinda Tan,Jeanne Barbara Dy,Maria Jimena Salcedo-Arellano et al.
Maria Melinda Tan et al.
Mutations in the Fragile X Mental Retardation 1 (FMR1) gene create a spectrum of developmental disorders in children in addition to neurodegenerative problems in older populations. Two types of mutations are recognized in the FMR1 gene. The...
Motor neuron biology and disease: A current perspective on infantile-onset spinal muscular atrophy [0.03%]
运动神经元生物学和疾病：对婴儿期脊髓性肌肉萎缩症的当前认识
Narendra N Jha,Jeong-Ki Kim,Umrao R Monani
Narendra N Jha
Infantile-onset spinal muscular atrophy (SMA) is a prototypical disease in which to investigate selective neurodegenerative phenotypes. Caused by low levels of the ubiquitously expressed Survival Motor Neuron (SMN) protein, the disease main...
Motor neuron biology and disease: A current perspective on infantile-onset spinal muscular atrophy [0.03%]
运动神经元生物学和疾病：对婴儿期起病的脊髓性肌萎缩症的当前看法
Narendra N Jha,Jeong-Ki Kim,Umrao R Monani
Narendra N Jha
Infantile-onset spinal muscular atrophy (SMA) is a prototypical disease in which to investigate selective neurodegenerative phenotypes. Caused by low levels of the ubiquitously expressed Survival Motor Neuron (SMN) protein, the disease main...
Katya T Potkin,Steven G Potkin
Katya T Potkin
Huntington disease (HD) is an autosomal dominantly inherited neurodegenerative disease that affects motor, cognitive and psychiatric functions, and ultimately leads to death. The pathology of the disease is based on an expansion of CAG repe...
Swapna Putta,Page B Pennell
Swapna Putta
Child-bearing years are often the most precarious management period in the life of a woman with epilepsy. This article reviews the results of many different studies with findings that enable the healthcare team to make confident decisions a...
Jennifer L Griffith,Michael Wong
Jennifer L Griffith
Nearly a third of patients with epilepsy have seizures refractory to current medical therapies. In the search for novel drug targets, the mTOR pathway has emerged as key in the regulation of neuronal function, growth and survival, and other...
Optimizing mouse models of neurodegenerative disorders: are therapeutics in sight? [0.03%]
优化神经退行性疾病的小鼠模型：治疗方法会成为现实吗？
Cathleen M Lutz,Melissa A Osborne
Cathleen M Lutz
The genomic and biologic conservation between mice and humans, along with our increasing ability to manipulate the mouse genome, places the mouse as a premier model for deciphering disease mechanisms and testing potential new therapies. Des...
Comorbid autism spectrum disorder and anxiety disorders: a brief review [0.03%]
共病孤独症谱系障碍和焦虑障碍：综述性文章
Brian A Zaboski,Eric A Storch
Brian A Zaboski
Appearing in 40% of the cases of autism spectrum disorder (ASD), comorbid anxiety presents unique challenges for practitioners by amplifying problem behaviors such as social skills deficits, resistance to change and repetitive behaviors. Fu...
What goes up must come down: homeostatic synaptic plasticity strategies in neurological disease [0.03%]
涨必有跌：神经性疾病中的稳态突触可塑性策略
Emily A André,Patrick A Forcelli,Daniel Ts Pak
Emily A André
Brain activity levels are tightly regulated to minimize imbalances in activity state. Deviations from the normal range of activity are deleterious and often associated with neurological disorders. To maintain optimal levels of activity, reg...