What can post-mortem studies tell us about the pathoetiology of suicide? [0.03%]
尸体解剖研究能告诉我们关于自杀发病机制的哪些信息？
Ghanshyam N Pandey,Yogesh Dwivedi
Ghanshyam N Pandey
Suicide is a major public health concern; however, its neurobiology is unclear. Post-mortem brain tissue obtained from suicide victims and normal controls offers a useful method for studying the neurobiology of suicide. Despite several limi...
Recent trends in rehabilitation interventions for visual neglect and anosognosia for hemiplegia following right hemisphere stroke [0.03%]
近期右侧半球卒中后视觉忽略和偏瘫无意识康复干预的最新趋势
Kathleen B Kortte,Argye E Hillis
Kathleen B Kortte
This article highlights the most recent findings regarding the rehabilitation interventions for the syndromes of visual neglect and anosognosia for hemiplegia that occur following right hemisphere stroke. We review papers published in the p...
Neural pathways for language in autism: the potential for music-based treatments [0.03%]
自闭症的语言神经通路：基于音乐的治疗方法的潜力
Catherine Y Wan,Gottfried Schlaug
Catherine Y Wan
Language deficits represent the core diagnostic characteristics of autism, and some of these individuals never develop functional speech. The language deficits in autism may be due to structural and functional abnormalities in certain langu...
Gottfried Schlaug,Andrea Norton,Sarah Marchina et al.
Gottfried Schlaug et al.
It has been reported for more than 100 years that patients with severe nonfluent aphasia are better at singing lyrics than they are at speaking the same words. This observation led to the development of melodic intonation therapy (MIT). How...
Inter-relationships among behavioral markers, genes, brain and treatment in dyslexia and dysgraphia [0.03%]
阅读和书写障碍中的行为标志、基因、大脑及治疗间的相互关系
Virginia Berninger,Todd Richards
Virginia Berninger
Cross-country, longitudinal twin studies provide strong evidence for both the biological and environmental basis of dyslexia, and the stability of genetic influences on reading and spelling, even when skills improve in response to instructi...
Estimating and disclosing the risk of developing Alzheimer's disease: challenges, controversies and future directions [0.03%]
阿尔茨海默病发病风险的评估与披露：挑战、争议及未来方向
J Scott Roberts,Sarah M Tersegno
J Scott Roberts
With Alzheimer's disease increasing in prevalence and public awareness, more people are becoming interested in learning their chances of developing this condition. Disclosing Alzheimer's disease risk has been discouraged because of the limi...
Insights into neurogenesis and aging: potential therapy for degenerative disease? [0.03%]
神经发生与衰老研究新进展：退行性疾病治疗的可能途径？
Robert A Marr,Rosanne M Thomas,Daniel A Peterson
Robert A Marr
Neurogenesis is the process by which new neural cells are generated from a small population of multipotent stem cells in the adult CNS. This natural generation of new cells is limited in its regenerative capabilities and also declines with ...
Amyloid precursor protein and tau transgenic models of Alzheimer's disease: insights from the past and directions for the future [0.03%]
阿尔茨海默病的淀粉样前体蛋白和tau转基因模型：过去的经验与未来的方向
Naruhiko Sahara,Jada Lewis
Naruhiko Sahara
During the last 20 years, our understanding of the mechanisms underlying Alzheimer's disease (AD) has considerably improved, in part owing to both in vitro and in vivo model systems. Studies in mice expressing both human amyloid precursor p...
Scott Edwards,George F Koob
Scott Edwards
The progression from recreational drug use to drug addiction impacts multiple neurobiological processes and can be conceptualized as a transition from positive to negative reinforcement mechanisms driving both drug-taking and drug-seeking b...
Jonathan R Weinstein,Ines P Koerner,Thomas Möller
Jonathan R Weinstein
Microglia are resident CNS immune cells that are active sensors in healthy brain and versatile effectors under pathological conditions. Cerebral ischemia induces a robust neuroinflammatory response that includes marked changes in the gene-e...