Michael Wong
Michael Wong
Current treatments for epilepsy suffer from significant limitations, including medical intractability and lack of disease-modifying or anti-epileptogenic actions. As most current seizure medications modulate ion channels and neurotransmitte...
ADVANCES IN THE CELL-BASED TREATMENT OF NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY [0.03%]
细胞疗法治疗新生儿缺氧缺血性脑损伤的研究进展
Mibel M Pabon,Cesar V Borlongan
Mibel M Pabon
Stem cell therapy for adult stroke has reached limited clinical trials. Here, we provide translational research guidance on stem cell therapy for neonatal hypoxic-ischemic brain injury requiring a careful consideration of clinically relevan...
Persistent region-dependent neuroinflammation, NMDA receptor loss and atrophy in an animal model of penetrating brain injury [0.03%]
穿通性脑损伤动物模型中的持续区域依赖性神经炎症、N-甲基-D天冬氨酸受体丢失和萎缩
Rachel Grossman,Charles M Paden,Pamela A Fry et al.
Rachel Grossman et al.
Dynamic changes in neuroinflammation and glutamate NMDA receptors (NMDAR) have been noted in traumatic and ischemic brain injury. Aim: Here we investigate...
M Matthew Oh,John F Disterhoft
M Matthew Oh
Getting gray hair is part of the natural progression of aging. People expect it and they can change their hair color, if they choose. People also expect increases in memory lapses and learning difficulties as they get older. However, unlike...
Ehren L Newman,Christopher F Shay,Michael E Hasselmo
Ehren L Newman
In this article, we will describe the malignant synaptic growth hypothesis of Alzheimer's disease. Originally presented in 1994, the hypothesis remains a viable model of the functional and biophysical mechanisms underlying the development a...
Kathy R Magnusson
Kathy R Magnusson
Our elderly population is growing and declines in cognitive abilities, such as memory, can be costly, because it can interfere with a person's ability to live independently. The NMDA receptor is very important for many different forms of me...
Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders [0.03%]
打开潘多拉的盒子：CRMP2在多种神经退行性疾病、感觉和运动神经元以及中枢系统疾病中潜在作用综述
Rajesh Khanna,Sarah M Wilson,Joel M Brittain et al.
Rajesh Khanna et al.
CRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein that mediates axon/dendrite specification and axonal growth. Mapping the CRMP2 interactome has revealed previously unappreciated functions subserved by th...
The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease [0.03%]
胞内转运及VPS10d受体在阿尔茨海默病中的作用
Christiane Reitz
Christiane Reitz
In Alzheimer's disease, the key pathological culprit is the amyloid-β protein, which is generated through β- and γ-secretase cleavage of the amyloid-β precursor protein (APP). Both the secretases and amyloid-β precursor protein are tra...
A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR [0.03%]
神经性疾病中的关键激酶级联反应：PI 3-K、Akt和mTOR
Zhao Zhong Chong,Yan Chen Shang,Shaohui Wang et al.
Zhao Zhong Chong et al.
Neurodegenerative disorders lead to disability and death in a significant proportion of the world's population. However, many disorders of the nervous system remain with limited effective treatments. Kinase pathways in the nervous system th...
Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress [0.03%]
阿尔茨海默病的分子神经病理发生机制：一个强调氧化应激中心作用的交互模型
Roberto Rodrigues,Mark A Smith,Xinglong Wang et al.
Roberto Rodrigues et al.
Alzheimer's disease (AD) exhibits a complex etiology that simultaneously manifests as a complex cellular, neurobiological, molecular, anatomic-physiological and clinical entity. Other significant psychiatric conditions, such as depression a...