Inflammation and human cerebral aneurysms: current and future treatment prospects [0.03%]
炎症与人类脑动脉瘤：目前和未来的治疗前景
Joseph S Hudson,Danielle S Hoyne,David M Hasan
Joseph S Hudson
The formation of cerebral aneurysms and their rupture propensity is of immediate clinical importance. Current management includes observation with expectant management, microsurgical clipping and/or endovascular coiling. The surgical option...
Shinghua Ding
Shinghua Ding
Astrocytes are the predominant glial cell type in the CNS. Although astrocytes are electrically nonexcitable, their excitability is manifested by their Ca2+ signaling, which serves as a mediator of neuron-glia bidirectional interactions via...
Recent Progress in Rett Syndrome and MeCP2 Dysfunction: Assessment of Potential Treatment Options [0.03%]
近年瑞特综合征及相关甲基胞嘧啶结合蛋白2功能障碍的研究进展及潜在治疗手段评估
Christopher A Chapleau,Jane Lane,Jennifer Larimore et al.
Christopher A Chapleau et al.
Synaptic communication is highly regulated process of contact between cells allowing information to be stored and modified. Synaptic formation and maturation is the result of interactions between intrinsic genetic/molecular factors and the ...
Jane S Paulsen
Jane S Paulsen
Huntington disease (HD) is a devastating illness, although its autosomal dominant genetic transmission allows a unique opportunity to study apparently healthy individuals before manifest disease. Attempts to study early disease are not uniq...
Therapy development for neuromuscular diseases: translating hope into promise [0.03%]
神经肌肉疾病的治疗研究：化希望为现实
Carmen Bertoni
Carmen Bertoni
The Second Muscular Dystrophy Association Scientific Meeting was held on 21-24 April 2013 in Washington (DC, USA). The meeting provided an opportunity for research scientists, clinicians, government agencies and industry experts to highligh...
Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains? [0.03%]
CD200及其受体的神经生物学研究：控制人类大脑炎症的治疗靶点？
Douglas G Walker,Lih-Fen Lue
Douglas G Walker
CD200 and its receptor, CD200 receptor (CD200R), have uniaue roles in controlling damaging inflammatory processes. At present, the only identified function for CD200 is as a ligand for CD200R. These proteins interact resulting in the activa...
Advances in the treatment of visual hallucinations in neurodegenerative diseases [0.03%]
神经退行性疾病的视觉幻觉治疗进展
Daniel Collerton,John-Paul Taylor
Daniel Collerton
Treatment of visual hallucinations in neurodegenerative disorders is not well advanced. The complexity of underlying mechanisms presents a number of potential avenues for developing treatments, but also suggests that any single one may be o...
Phillip L Pearl,Thomas R Hartka,Jessica L Cabalza et al.
Phillip L Pearl et al.
The inherited disorders of γ-amino butyric acid (GABA) metabolism require an increased index of clinical suspicion. The known genetic disorders are GABA-transaminase deficiency, succinic semialdehyde dehydrogenase (SSADH) deficiency and ho...
Alexei Verkhratsky,José J Rodríguez,Vladimir Parpura
Alexei Verkhratsky
Astroglia encompass a subset of versatile glial cells that fulfill a major homeostatic role in the mammalian brain. Since any brain disease results from failure in brain homeostasis, astroglial cells are involved in many, if not all, aspect...
The expanding genomic landscape of autism: discovering the 'forest' beyond the 'trees' [0.03%]
自闭症的基因组景观：见森林而不仅仅树木
Valerie W Hu
Valerie W Hu
Autism spectrum disorders are neurodevelopmental disorders characterized by significant deficits in reciprocal social interactions, impaired communication and restricted, repetitive behaviors. As autism spectrum disorders are among the most...