What have novel imaging techniques revealed about metabolism in the aging brain? [0.03%]
新的影像技术揭示了什么关于衰老大脑中的代谢的信息？
Ai-Ling Lin,Douglas L Rothman
Ai-Ling Lin
Brain metabolism declines with age and do so in an accelerated manner in neurodegenerative disorders. Noninvasive neuroimaging techniques have played an important role to identify the metabolic biomarkers in aging brain. Particularly, PET w...
Insights into synaptic function from mouse models of human cognitive disorders [0.03%]
来自人类认知障碍小鼠模型的突触功能洞察
Jessica L Banko,Justin Trotter,Edwin J Weeber
Jessica L Banko
Modern approaches to the investigation of the molecular mechanisms underlying human cognitive disease often include multidisciplinary examination of animal models engineered with specific mutations that spatially and temporally restrict exp...
Towards an Understanding of Neuropsychiatric Manifestations in Fragile X Premutation Carriers [0.03%]
脆性X综合征前突变携带者的神经精神表现初探
Aaron D Besterman,Scott A Wilke,Tua-Elisabeth Mulligan et al.
Aaron D Besterman et al.
Fragile X-associated disorders (FXD) are a group of disorders caused by expansion of non-coding CGG repeat elements in the fragile X (FMR1) gene. One of these disorders, fragile X syndrome (FXS), is the most common heritable cause of intell...
Ana Recober,B Lee Peterlin
Ana Recober
Axonal tract tracing for delineating interacting brain regions: implications for Alzheimer's disease-associated memory [0.03%]
轴索追踪法界定阿尔茨海默病相关记忆相互作用脑区的作用
Thomas van Groen,Pasi Miettinen,Inga Kadish
Thomas van Groen
We are studying the projections from the entorhinal cortex to the hippocampal formation in the mouse. The dentate gyrus is innervated by the lateral entorhinal cortex (lateral perforant path) and medial entorhinal cortex (medial perforant p...
Neurodegeneration in spinal muscular atrophy: from disease phenotype and animal models to therapeutic strategies and beyond [0.03%]
脊髓性肌萎缩的神经退行性变：从疾病表型和动物模型到治疗策略及未来展望
Umrao R Monani,Darryl C De Vivo
Umrao R Monani
Of the numerous inherited diseases known to afflict the pediatric population, spinal muscular atrophy (SMA) is among the most common. It has an incidence of approximately one in 10,000 newborns and a carrier frequency of one in 50. Despite ...
Molecular contributions to neurovascular unit dysfunctions after brain injuries: lessons for target-specific drug development [0.03%]
脑损伤后的神经血管单元功能障碍的分子病因及药物治疗靶点研究
Amandine Jullienne,Jérôme Badaut
Amandine Jullienne
The revised 'expanded' neurovascular unit (eNVU) is a physiological and functional unit encompassing endothelial cells, pericytes, smooth muscle cells, astrocytes and neurons. Ischemic stroke and traumatic brain injury are acute brain injur...
Diffusion tensor imaging and related techniques in tuberous sclerosis complex: review and future directions [0.03%]
结节性硬化症复杂型的弥散张量成像及相关的技术：综述与未来方向
Jurriaan M Peters,Maxime Taquet,Anna K Prohl et al.
Jurriaan M Peters et al.
In this article, the authors aim to introduce the nonradiologist to diffusion tensor imaging (DTI) and its applications to both clinical and research aspects of tuberous sclerosis complex. Tuberous sclerosis complex is a genetic neurocutane...
Neuronal adhesion and synapse organization in recovery after brain injury [0.03%]
脑损伤后的神经元黏附和突触组织的恢复机制研究
Kellie Park,Thomas Biederer
Kellie Park
Few specific therapeutic targets exist to manage brain injury, despite the prevalence of stroke or traumatic brain injury. With traumatic brain injury, characteristic neuronal changes include axonal swelling and degeneration, and the loss o...
The genetics of progressive hearing loss: a link between hearing impairment and dysfunction of mechanosensory hair cells [0.03%]
进行性听力损失的遗传学：听觉损伤和机械感觉毛细胞功能障碍之间的联系
Ulrich Müller,Nicolas Grillet
Ulrich Müller