The hippocampo-prefrontal pathway: a possible therapeutic target for negative and cognitive symptoms of schizophrenia [0.03%]
海马前额通路可能成为治疗精神分裂症阴性和认知症状的靶点
Ayan Ghoshal,P Jeffrey Conn
Ayan Ghoshal
The hippocampo-prefrontal (H-PFC) pathway has been linked to cognitive and emotional disturbances in several psychiatric disorders including schizophrenia. Preclinical evidence from the NMDA receptor antagonism rodent model of schizophrenia...
Anatomical, functional and molecular biomarker applications of magnetic resonance neuroimaging [0.03%]
磁共振神经影像的解剖、功能和分子生物标志物应用
Christina H Liu
Christina H Liu
MRI and magnetic resonance spectroscopy (MRS) along with computed tomography and PET are the most common imaging modalities used in the clinics to detect structural abnormalities and pathological conditions in the brain. MRI generates super...
Human-derived natural antibodies: biomarkers and potential therapeutics [0.03%]
人类来源的天然型抗体：生物标志物和潜在药物分子
Xiaohua Xu,Sher May Ng,Eamonn Hassouna et al.
Xiaohua Xu et al.
The immune system generates antibodies and antigen-specific T-cells as basic elements of the immune networks that differentiate self from non-self in a finely tuned manner. The antigen-specific nature of immune responses ensures that normal...
Facial neuropathy with imaging enhancement of the facial nerve: a case report [0.03%]
面部神经病伴面神经影像增强1例报告
Sehreen Mumtaz,Matthew B Jensen
Sehreen Mumtaz
A young women developed unilateral facial neuropathy 2 weeks after a motor vehicle collision involving fractures of the skull and mandible. MRI showed contrast enhancement of the facial nerve. We review the literature describing facial neur...
Animal models of stroke: translational potential at present and in 2050 [0.03%]
卒中动物模型：目前及未来对转化研究的潜力
Paco S Herson,Richard J Traystman
Paco S Herson
Translation from basic science bench research in ischemic stroke to bedside treatment of patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of compounds and interventions that provide benefit in exp...
Christiane Reitz
Christiane Reitz
The article by Lambert et al. reports the identification of 11 novel susceptibility loci for late-onset Alzheimer's disease. The observations of this study significantly enhance the field since they further disentangle the genetic causes an...
In vivo characterization of brain iron with magnetic field correlation imaging [0.03%]
基于磁场相关性的脑铁体模和在体表征研究
Jens H Jensen,Joseph A Helpern
Jens H Jensen
Brian A Gordon,Tyler Blazey,Tammie Ls Benzinger
Brian A Gordon
Alleviating brain stress: what alternative animal models have revealed about therapeutic targets for hypoxia and anoxia [0.03%]
缓解脑部压力：替代动物模型对缺氧和无氧治疗靶点的启示
Sarah L Milton,Ken Dawson-Scully
Sarah L Milton
While the mammalian brain is highly dependent on oxygen, and can withstand only a few minutes without air, there are both vertebrate and invertebrate examples of anoxia tolerance. One example is the freshwater turtle, which can withstand da...
Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia [0.03%]
小脑皮质神经元生理学及其在显性遗传共济失调中的应用进展
Ravi Chopra,Vikram G Shakkottai
Ravi Chopra
The cerebellum is an important structure for accurate control and timing of movement, and Purkinje neurons in the cerebellar cortex are key players in cerebellar motor control. Cerebellar dysfunction can result in ataxia, a disorder charact...