Wenxi Yu,Miriam L Greenberg
Wenxi Yu
Valproic acid and lithium are widely used to treat bipolar disorder, a severe illness characterized by cycles of mania and depression. However, their efficacy is limited, and treatment is often accompanied by serious side effects. The thera...
Parkinson's Disease: What role do pedunculopontine nucleus cholinergic neurons play? [0.03%]
皮层脑桥核胆碱能神经元在帕金森病中扮演什么角色？
Nicolaas I Bohnen,Martijn L T M Müller,William T Dauer et al.
Nicolaas I Bohnen et al.
A report of nontraumatic cortical subarachnoid hemorrhage and subsequent management [0.03%]
非创伤性脑皮层硬膜下出血的报告及后续处理措施研究
David Qiyuan Mao,Daniel Addess,Helen Valsamis
David Qiyuan Mao
Aim: Report a case of cortical subarachnoid hemorrhage (cSAH) and discuss its management. Patient & methods: A 66-year-old woman presen...
Neuroimaging chronic pain: what have we learned and where are we going? [0.03%]
慢性疼痛的神经影像学研究：我们已经了解了什么？未来的研究方向又是什么？
Katherine T Martucci,Pamela Ng,Sean Mackey
Katherine T Martucci
Advances in neuroimaging have helped illuminate our understanding of how the brain works in the presence of chronic pain, which often persists with unknown etiology or after the painful stimulus has been removed and any wounds have healed. ...
CNS autoimmune disease after Streptococcus pyogenes infections: animal models, cellular mechanisms and genetic factors [0.03%]
链球菌感染后中枢神经系统自身免疫病：动物模型、细胞机制和遗传因素
Tyler Cutforth,Mellissa Mc DeMille,Ilir Agalliu et al.
Tyler Cutforth et al.
Streptococcus pyogenes infections have been associated with two autoimmune diseases of the CNS: Sydenham's chorea (SC) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus infections (PANDAS). Despite the high f...
Christiane Reitz
Christiane Reitz
Late-onset Alzheimer's disease (AD), a highly prevalent neurodegenerative disorder characterized by progressive deterioration in cognition, function and behavior terminating in incapacity and death, is a clinically and pathologically hetero...
Cesar V Borlongan,Jukka Jolkkonen,Olivier Detante
Cesar V Borlongan
Maya Elias,Jaclyn Hoover,Hung Nguyen et al.
Maya Elias et al.
Unlocking truths of γ-secretase in Alzheimer's disease: what is the translational potential? [0.03%]
解锁与阿尔茨海默病有关的γ-分泌酶之谜：转化前景如何？
Michael S Wolfe
Michael S Wolfe
Considerable evidence, particularly from genetics, points to the aggregation-prone amyloid β-peptide as a pathogenic entity in Alzheimer's disease. Hence, the proteases that produce this peptide from its precursor protein have been prime t...
Evidence from the R6/2 Mouse Model of Huntington's Disease for Using Abnormal Brain Metabolism as a Biomarker for Evaluating Therapeutic Approaches for Treatment [0.03%]
利用R6/2亨廷顿舞蹈病小鼠模型研究异常脑代谢作为评估治疗措施的生物标志物证据
Anna Parievsky,Carlos Cepeda,Michael S Levine
Anna Parievsky
Huntington's disease (HD) is an autosomal dominant genetic disorder characterized by a progression of motor abnormalities as well as cognitive and psychiatric symptoms [1]. Presently, there is no cure for HD and no treatment to reverse its ...