Essential function, sophisticated regulation and pathological impact of the selective RNA-binding protein QKI in CNS myelin development [0.03%]
RNA结合蛋白QKI在CNS髓鞘发育中的基本功能、精细调控及病理影响
Katrina Bockbrader,Yue Feng
Katrina Bockbrader
The selective RNA-binding protein QKI play a key role in advancing oligodendrocyte-dependent myelination, which is essential for the function and development of the CNS. The emerging evidence that QKI abnormalities are associated with schiz...
Experience--a double edged sword for restorative neural plasticity after brain damage [0.03%]
经历是一把双刃剑：利于脑损伤后的修复性神经可塑性
Rachel P Allred,Theresa A Jones
Rachel P Allred
During the time period following damage, the brain undergoes widespread reorganizational processes. Manipulations of behavioral experience can be potent therapeutic interventions for shaping this reorganization and enhancing long-term funct...
Corticotropin-Releasing Hormone (CRH) Programs the Fetal and Maternal Brain [0.03%]
促肾上腺皮质激素释放激素（CRH）编程胎儿和母体大脑
Curt A Sandman,Laura M Glynn
Curt A Sandman
Heather Melrose
Heather Melrose
The etiology of Parkinson's disease (PD) was long thought to be due to environmental factors. Following the discovery of autosomal-dominant mutations in the α-synuclein gene, and later recessive mutations in the DJ-1, Parkin and PINK-1 gen...
Growth factor regulation of remyelination: behind the growing interest in endogenous cell repair of the CNS [0.03%]
生长因子与再生髓鞘：中枢神经系统内源性细胞修复的研究进展
Regina C Armstrong
Regina C Armstrong
Remyelination facilitates recovery of saltatory conduction along demyelinated axons and may help prevent axon damage in patients with demyelinating diseases, such as multiple sclerosis. The extent of remyelination in multiple sclerosis lesi...
Autophagy in neuroprotection and neurodegeneration: A question of balance [0.03%]
自噬在神经保护和神经变性中的作用：平衡的问题
Salvatore J Cherra rd,Charleen T Chu
Salvatore J Cherra rd
A central issue in developing therapies for neurodegenerative diseases involves understanding why adaptive responses to stress or injury fail to prevent synaptic dysfunction and neuronal cell death. Macroautophagy is a major, evolutionarily...