Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair [0.03%]
他汀类药物治疗多发性硬化症的潜力：免疫调节、神经保护和神经修复
Silva Markovic-Plese,Avtar K Singh,Inderjit Singh
Silva Markovic-Plese
Statins as inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A reductase are widely used as cholesterol-lowering drugs. Recent studies provide evidence that the anti-inflammatory activity of statins, which is independent of their cholester...
Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease? [0.03%]
阿尔茨海默病中轴突运输异常是病因还是结果？
Virgil Muresan,Zoia Muresan
Virgil Muresan
Axonal transport, the process by which membrane-bound organelles and soluble protein complexes are transported into and out of axons, ensures proper function of the neuron, including that of the synapse. As such, abnormalities in axonal tra...
Elena L Grigorenko
Elena L Grigorenko
Autism spectrum disorders (ASDs) are relatively infrequent but are devastating developmental conditions characterized by marked deficiencies in social, communicative and other behavioral domains. It has been known for a substantial period o...
Don Gilden,Maria A Nagel,Ravi Mahalingam et al.
Don Gilden et al.
A declining cell-mediated immunity to varicella zoster virus (VZV) with advancing age or immunosuppression results in virus reactivation from latently infected human ganglia anywhere along the neuraxis. Virus reactivation produces zoster, o...
Vidya Gopalakrishnan
Vidya Gopalakrishnan
Since its original discovery as a negative regulator of neuronal differentiation, the repressor element (RE)-1 silencing transcription factor (REST), also known as the neuron-restrictive silencer factor, has been implicated in novel process...
Receptor for advanced glycation end products: its role in Alzheimer's disease and other neurological diseases [0.03%]
晚期糖基化终产物受体在阿尔茨海默病及其他神经退行性疾病中的作用
Lih-Fen Lue,Douglas Gordon Walker,Sandra Jacobson et al.
Lih-Fen Lue et al.
The receptor for advanced glycation end products (RAGE) has been demonstrated to play a central role in the pathogenic mechanisms of a growing number of important neurological diseases, including Alzheimer's disease (AD) and stroke. Two fun...
It's all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection [0.03%]
TLR家族成员成为卒中神经保护治疗新靶点的潜力不容忽视
Philberta Y Leung,Amy Eb Packard,Mary P Stenzel-Poore
Philberta Y Leung
Ischemic tolerance is a biological process that can be utilized to unlock the brain's own endogenous protection mechanisms and, as such, holds true promise for patients at risk of ischemic injury. Experimentally, preconditioning with variou...
Antidepressant-coincident mania in children and adolescents treated with selective serotonin reuptake inhibitors [0.03%]
选择性5-羟色胺再摄取抑制剂治疗的儿童和青少年 antidepressant-coincident 躁狂症患者研究
Megan F Joseph,Eric A Youngstrom,Jair C Soares
Megan F Joseph
Several factors have amplified concern about the possibility that antidepressant medication may contribute to induction of pediatric mania. These include the high rate of antidepressant medication prescription, the recent surge in the rate ...
Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent [0.03%]
可溶性环氧化物水解酶抑制作用：一种药物同时靶向缺血性脑损伤的多种机制
Jeffrey J Iliff,Nabil J Alkayed
Jeffrey J Iliff
Soluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs). Genetic variations in the sEH gene, designated EPHX2, are associated with ischemic stro...
The Implications of the Cancer Stem Cell Hypothesis for Neuro-Oncology and Neurology [0.03%]
癌症干细胞假说对神经肿瘤学和神经病学的意义
Jeremy N Rich
Jeremy N Rich
The cancer stem cell hypothesis posits that cancers contain a subset of neoplastic cells that propagate and maintain tumors through sustained self-renewal and potent tumorigenecity. Recent excitement has been generated by a number of report...