Tumor exosomal miR-221-3p induces glycolysis through the LIFR/GLUT1 pathway to destroy the cerebral vascular endothelial cell barrier and promote breast cancer brain metastasis [0.03%]
肿瘤源小胶质细胞外囊泡介导miR-221-3p通过LIFR/GLUT1通路诱导糖酵解破坏脑血管内皮屏障促进乳腺癌脑转移
Kaitao Zhu,Hongru Yao,Jilong Hei et al.
Kaitao Zhu et al.
Background: Tumor-derived exosomal microRNAs mediate intercellular communication between malignant cells and distant organs and play a pivotal role in metastatic dissemination. Breast cancer brain metastasis (BCBM) poses ...
15,16-Dihydrotanshinone I, a novel β-catenin-targeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer [0.03%]
靶向抑制β-连环素并减少其下游CD36表达的抗癌新成分丹参酮I乙酸酯
Minting Chen,Baisen Chen,Qianyi He et al.
Minting Chen et al.
Background: Wnt/β-catenin signaling drives many cancers; however, current inhibition strategies have limitations. Direct β-catenin inhibitors that block nuclear translocation represent an alternative therapeutic approac...
Correction: Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma [0.03%]
纠正：补体C3a通过抑制Sirt1激活PI3K/PDK1/SGK3途径促进骨髓瘤患者破骨细胞的形成
Fengjuan Jiang,Yunhe Zhang,Fengping Peng et al.
Fengjuan Jiang et al.
Published Erratum
Journal of translational medicine. 2025 Nov 21;23(1):1329. DOI:10.1186/s12967-025-07335-z 2025
Feeding intelligence: comparative evaluation of ChatGPT and clinical guidelines for nutritional management in head and neck cancer [0.03%]
头颈部癌症营养管理中ChatGPT与临床指南的比较评价
Shasha Shen,Kai Zhou,Mingna Wu et al.
Shasha Shen et al.
Bridging pharmacovigilance and genetic insight: investigating drugs and indications for breast cancer risk in women with autoimmune diseases [0.03%]
药理警戒和基因洞察的桥梁作用：在自身免疫性疾病女性患者中研究药物和乳腺癌风险适应证
Ningning Song,Xinquan Xi,Kejian Zhang et al.
Ningning Song et al.
Background: Women with autoimmune diseases (AIDs) experience chronic immune dysregulation and hormonal fluctuations, both of which may influence breast cancer risk. However, it remains unclear whether this risk is driven ...
Cisplatin-mediated activation of NF-κB promotes lung cancer stem cell formation via DNA repair pathways [0.03%]
顺铂介导的NF-κB活化通过DNA修复途径促进肺癌干细胞的形成
Lingyu Zhang,Qiumei Li,Chunjiang Liu et al.
Lingyu Zhang et al.
Background: Cisplatin (DDP) an effective DNA-damaging agent, is fundamental in treating non-small cell lung cancer (NSCLC). Resistance to DDP remains a significant challenge in the treatment of NSCLC. This study aimed to ...
Immune cell dynamics, cytokines, and extracellular vesicles in systemic inflammatory response syndrome (SIRS): a multiparametric analysis [0.03%]
全身炎症反应综合征(SIRS)中免疫细胞动力学、细胞因子和胞外囊泡的多参数分析
Gerardo J Martí-Chillón,Sandra Muntión,Juan Flores-Montero et al.
Gerardo J Martí-Chillón et al.
Background: The systemic inflammatory response syndrome (SIRS) is a complex and multifactorial life-threatening reaction triggered by trauma or infection (sepsis). Since the dynamics of immune cells, cytokines and novel m...
Radiation meets inflammation: NLRP3 inflammasome at the core of radiation-induced cardiac injury [0.03%]
辐射与炎症：NLRP3炎性小体在放射诱发的心脏损伤中的核心作用
Caterina Boncompagni,Stefania Giacovazzi,Mariasole Perrone et al.
Caterina Boncompagni et al.
Radiation therapy is a widely used and effective treatment for various types of cancer; however, it is associated with several side effects, including an increased risk of cardiovascular disease. While the molecular mechanisms underlying RT...
Machine learning-powered discovery of a novel berberine derivative inducing SCD-dependent ferroptosis in osteosarcoma [0.03%]
一种新型小分子巴马汀衍生物通过诱导软骨肉瘤细胞中柠檬酸合成酶依赖的铁死亡的研究发现
Mingyu He,Yanyan Liu,Tao Li et al.
Mingyu He et al.
Background: Despite decades of therapeutic development, osteosarcoma survival remains poor. Although berberine (BBR) shows anti-tumor activity, its efficacy is limited. We addressed this through structural modification an...
Triad of homocysteine, ROCK2 and vimentin as a convergent biomarker signature in pseudoexfoliation [0.03%]
以假性剥脱为模型的眼内同型半胱氨酸、ROCK2和波形蛋白的汇聚生物标志物谱型研究
Lipsa Sahoo,Pranjya Paramita Mohanty,Debasmita Pankaj Alone
Lipsa Sahoo
Background: Pseudoexfoliation (PEX) is a complex age-related disorder traditionally considered ocular in origin but increasingly recognized as a systemic condition involving extracellular matrix (ECM) dysregulation, oxida...