Targeting the IL-17C-M2 macrophage axis ameliorates fibrosis in endometriosis through MAPK/ERK signaling [0.03%]
靶向IL-17C-M2巨噬细胞轴通过MAPK/ERK信号通路改善子宫内膜异位症纤维化
Jingling Li,Bo Yao,Liuying Chu et al.
Jingling Li et al.
Background: Endometriosis is characterized by inflammation and fibrosis, in which cytokines and cytokine-macrophage interactions serve as critical mediators. However, the specific mechanisms that initiate the fibrotic cas...
ICH E21: from landmark guidance to specific action for maternal and child health [0.03%]
国际人用药物注册技术要求国际协调会E21号指导原则：从重要指导到具体的行动——促进孕产妇和儿童健康药物的注册
Myriam El Gaaloul;Collaborative Group on Global Maternal and Child Health
Myriam El Gaaloul;Collaborative Group on Global Maternal and Child Health
Supplementation of αKG along with TGFβ/HIF1α antagonist rescues lung fibrosis in mice with severe SARS-CoV-2 infection [0.03%]
α酮基丁酸联合TGFβ / HIF1α拮抗剂可修复严重SARS-CoV-2感染小鼠的肺纤维化
Garima Joshi,Gulistan Parveen,Simran Kaur et al.
Garima Joshi et al.
Background: Pulmonary fibrosis and acute respiratory distress syndrome (ARDS) are the clinical challenges among patients with post-acute sequelae of COVID-19 (PASC), affecting ~ 10% of the survivors worldwide. PASC manife...
A comparative mutation-selection reanalysis of colon and rectal adenocarcinoma highlights PIK3CA variants and BRAF V600E [0.03%]
对结肠癌和直肠腺癌的比较突变选择再分析强调了PIK3CA变异体和BRAF V600E
Liangze Ke,Michael Cecchini,Jeffrey P Townsend
Liangze Ke
Interaction between p-AMPK and RIPK3 reveals a mechanism by which AdipoAI suppresses necroptosis to attenuate periodontitis [0.03%]
p-AMPK与RIPK3互作揭示了AdipoAI通过抑制坏死性凋亡来缓解牙周病的机制
Wei Qiu,Dian Ding,Jun Shao et al.
Wei Qiu et al.
Background: Necroptosis is implicated in the pathogenesis of various inflammatory diseases, including periodontitis. This study aimed to investigate the molecular mechanisms underlying necroptosis in gingival fibroblasts ...
Paola Manzo,Anna Lisa Cammarota,Anna Basile et al.
Paola Manzo et al.
Impaired NADH-linked mitochondrial respiration disrupts ventral midbrain neuronal programs in POLG disease [0.03%]
线粒体呼吸链NADH连接障碍干扰POLG病患者中脑腹区神经元程序
Anbin Chen,Tsering Yangzom,Gareth John Sullivan et al.
Anbin Chen et al.
Background: POLG (DNA polymerase γ catalytic subunit)-related mitochondrial diseases are among the most severe primary mitochondrial disorders and are characterized by progressive neurodegeneration with prominent dopamin...
Chemotherapy-driven gut microbiota remodeling in ovarian cancer: a prospective longitudinal study [0.03%]
化疗驱动的卵巢癌肠道微生态重塑：一项前瞻性纵向研究
Wenpei Shi,Na Li,Shanshan Cheng et al.
Wenpei Shi et al.
Background: The gut microbiome shapes chemotherapy efficacy and outcomes in several cancers, but evidence in ovarian cancer (OC) remains limited and largely cross-sectional. Despite high initial response rates, long-term ...
Modulating mesenchymal stromal cells chondrogenesis through TGF-β1 pre-conditioning during monolayer expansion in pellet culture and in a 3D mechanical load model [0.03%]
TGF-β1预处理调节单层细胞在聚集体培养和三维力学模型中的软骨分化性能
Maja Schlittler,Guoliang Chen,Lauma Ievina et al.
Maja Schlittler et al.
Background: Bone marrow-derived mesenchymal stem cells (MSCs) represent a promising source for cell-based regenerative cartilage therapies. However, in vitro chondrogenic differentiation of MSCs varies widely between dono...
Endostatin, chronic kidney disease (CKD) and anemia among older people: a secondary analysis of the screening for CKD among older people across Europe (SCOPE) study [0.03%]
内皮抑素、慢性肾脏病（CKD）和老年人贫血：欧洲老年人群中筛查CKD的二次分析（SCOPE研究）
Andrea Corsonello,Luca Soraci,Johan Ärnlöv et al.
Andrea Corsonello et al.
Background: Anemia is a common and debilitating complication of chronic kidney disease (CKD), but its pathogenesis remains incompletely understood. Endostatin, an anti-angiogenic peptide that is elevated in CKD, may impai...