Bacteria-derived glutarate mitigates Alzheimer's disease model pathology through autophagy-lysosomal pathway [0.03%]
细菌衍生的谷酰酸通过自噬溶酶体途径缓解阿尔茨海默病模型病理学
Cui Deng,Mingqin Qu,Wei Yao et al.
Cui Deng et al.
Probiotics exert neuroprotective effects against Alzheimer's disease (AD) by modulating gut-brain axis pathways, though disease-modifying therapies remain unavailable. Our study revealed that Escherichia coli (E. coli) strain HB101 ameliora...
Yuhan Jin,Yiran Liang,Mahsa Maghsoudy Kasvaei et al.
Yuhan Jin et al.
Breast cancer exhibits profound molecular and clinical heterogeneity, manifested through diverse subtypes, metastatic patterns, and therapeutic responses. Emerging evidence underscores that this complexity stems not merely from genetic and ...
ROR2 preserves alveolar bone homeostasis by orchestrating IRAK4-dependent suppression of CXCL8-driven osteolysis [0.03%]
ROR2通过调控IRAK4依赖的CXCL8介导的骨溶解抑制作用来维持牙槽骨稳态
Hong-Cheng Xing,Chen-Yang Qiu,Xiao-Yang Chu et al.
Hong-Cheng Xing et al.
Alveolar bone resorption, driven by imbalanced osteogenesis and osteolysis, is a hallmark of periodontitis and orthodontic complications, yet molecular mechanisms coordinating stromal-immune crosstalk remain elusive. Here, we identify recep...
Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and ciliary trafficking [0.03%]
巴尔德-毕舍综合征1型突变对BBSome完整性和纤毛转运的不同影响
Kristyna Maskova,Hana Hajsmanova,Sofiia Bykova et al.
Kristyna Maskova et al.
Background: Bardet-Biedl syndrome is a pleiotropic ciliopathy marked by retinal degeneration, obesity, polydactyly, renal and reproductive anomalies, and cognitive impairment. BBS1, the most frequently mutated gene in Bar...
CCL20-CCR6 axis in autoimmune disease and cancer progression: clinical and therapeutic implications [0.03%]
CCL20-CCR6轴在自身免疫病和肿瘤进展中的临床及治疗意义
Guanhua Yu,An Zhang,Yixiao Liu et al.
Guanhua Yu et al.
C-C motif chemokine ligand 20 (CCL20) is widely expressed in various human tissues and immune cells, playing a critical role in immune cell migration and inflammation. As the sole ligand of CCL20, C-C motif chemokine receptor 6 (CCR6) is a ...
Paraventricular oxytocin neurons attenuate post-ischemic brain injury by suppressing microglia-mediated neuroinflammation [0.03%]
室管膜下核催产素神经元通过抑制小胶质细胞介导的神经炎症减轻缺血性脑损伤
Rui Liu,Xinyu Yang,Haozhi Gong et al.
Rui Liu et al.
Background: Neuroinflammation is caused by the overactivation of microglia, contributing to secondary brain injury in ischemic stroke. Oxytocin (OXT), a neuropeptide synthesized by neurons in the paraventricular nucleus (...
Lipophagy in disease: signaling control, organelle communication, and therapeutic opportunities [0.03%]
脂质自噬与疾病：信号转导调控、细胞器互作及治疗机会
Yu-Yang Du,Xin-Yao Chen,Yue Fang et al.
Yu-Yang Du et al.
Lipid droplet (LD) accumulation and impaired lipid mobilization induce lipotoxic stress and contribute to metabolic, cardiovascular, cancer, and neurodegenerative diseases (NDDs). Although LD-selective autophagy (lipophagy) is being increas...
The multidimensional signaling of ELANE: from congenital hematopoietic failure to immune microenvironment crosstalk and targeted interventions [0.03%]
ELANE的多维度信号转导：从先天性造血失败到免疫微环境互作及靶向干预
Fu Zhang
Fu Zhang
Mutations in the neutrophil elastase gene (ELANE) have classically been established as the primary genetic etiology of severe congenital neutropenia (SCN) and cyclic neutropenia (CyN), characterized by early-stage granulocytic maturation ar...
FSTL4 interaction with Gαi proteins activates the Akt-mTOR pathway to drive malignant phenotypes in non-small cell lung cancer [0.03%]
FSTL4通过与Gαi蛋白的相互作用激活Akt-mTOR通路从而驱动非小细胞肺癌恶性表型的进展
Jiaxin Li,Wanghong Qi,Shansong Gao et al.
Jiaxin Li et al.
Non-small cell lung cancer (NSCLC) presents a critical challenge clinically; thus, identifying novel drivers and reliable prognostic biomarkers is imperative. Here, we investigated the clinical relevance, cell-type-specific localization, an...
SOX9: dosage- and context-dependent functions in pancreatic development and β-cell biology [0.03%]
SOX9：在胰腺发育和β细胞生物学中的剂量依赖性和上下文依赖性功能
Nour Sharar,Mohamed Eldaw,Zeyaul Islam et al.
Nour Sharar et al.
SOX9 is a highly conserved transcription factor (TF) belonging to the SRY-related HMG-box (SOX) family and the high-mobility group (HMG) class of DNA-binding proteins. SOX9 integrates structural flexibility, DNA-dependent dimerization, and ...