The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition [0.03%]
c-Abl-RACK1-FAK信号轴通过调节成纤维细胞肌成纤维细胞转化促进小鼠肾纤维化
Qianyi Bao,Anyu Wang,Wenxuan Hong et al.
Qianyi Bao et al.
Background: Renal fibrosis is a prevalent manifestation of chronic kidney disease (CKD), and effective treatments for this disease are currently lacking. Myofibroblasts, which originate from interstitial fibroblasts, aggr...
Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells [0.03%]
母猪心包脂肪组织单细胞核转录组揭示运动训练对常驻固有和适应性免疫细胞的影响
Irshad Ahmad,Shreyan Gupta,Patricia Faulkner et al.
Irshad Ahmad et al.
Background: Coronary artery disease (CAD) is a leading cause of death in women. Epicardial adipose tissue (EAT) secretes cytokines to modulate coronary artery function, and the release of fatty acids from EAT serves as a ...
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis [0.03%]
DEC1参与昼夜节律紊乱诱发的肺纤维化病理过程
Shuai-Jun Chen,Fan Yu,Xiao Feng et al.
Shuai-Jun Chen et al.
Background: The alveolar epithelial type II cell (AT2) and its senescence play a pivotal role in alveolar damage and pulmonary fibrosis. Cell circadian rhythm is strongly associated with cell senescence. Differentiated em...
Pan Zhou,Xingwen Meng,Zhimin Nie et al.
Pan Zhou et al.
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical tumor suppressor protein that regulates various biological processes such as cell proliferation, apoptosis, and inflammatory responses by controlling the phosphati...
Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds [0.03%]
靶向Wnt/β-catenin信号通路及其与TGF-β和Notch信号通路的相互作用以治疗慢性伤口
Dimakatso B Gumede,Heidi Abrahamse,Nicolette N Houreld
Dimakatso B Gumede
Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It is modulated by activation of pathways such as the transforming growth factor-beta (TGF-β), Notch, and Wnt/β-catenin signalin...
Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications [0.03%]
脓毒症诱导的急性肺损伤和急性呼吸窘迫综合征中的内皮细胞动态变化：发病机理与治疗意义
Xinyu Qiao,Junhao Yin,Zhihuan Zheng et al.
Xinyu Qiao et al.
Sepsis, a prevalent critical condition in clinics, continues to be the leading cause of death from infections and a global healthcare issue. Among the organs susceptible to the harmful effects of sepsis, the lungs are notably the most frequ...
PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation [0.03%]
PAX1抑制经典的Wnt信号通路并在内胚层分化中发挥双重作用
Danxiu Miao,Jie Ren,Yanhan Jia et al.
Danxiu Miao et al.
Background: Paired box 1 (PAX1) is a transcription factor and essential for the development of pharyngeal pouches-derived tissues, including thymus. PAX1 mutations are identified in Severe Combined Immunodeficiency (SCID)...
MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region [0.03%]
MSC来源的线粒体通过ROS诱导的DNA双链断裂上调Atf3基因促进轴突再生
Yingchi Zhang,Tao Xu,Jie Xie et al.
Yingchi Zhang et al.
Background: The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mito...
A promising frontier: targeting NETs for stroke treatment breakthroughs [0.03%]
充满希望的新领域——通过靶向细胞外诱捕网治疗卒中以取得新突破
Huijie Fang,Yunfei Bo,Zhongfei Hao et al.
Huijie Fang et al.
Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and release neutrophil extracellular...
Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future [0.03%]
治疗性细菌和病毒在抗癌中的作用：癌症治疗中的双刃剑：未来的新见解
Aref Yarahmadi,Mitra Zare,Masoomeh Aghayari et al.
Aref Yarahmadi et al.
Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges globally. The discovery and identific...