Aberrant activation of TGF-β/ROCK1 enhances stemness during prostatic stromal hyperplasia [0.03%]
TGF-β/ROCK1异常活化促进前列腺间质增生病程中的干细胞特性增强现象
Youyou Li,Jiaren Li,Liang Zhou et al.
Youyou Li et al.
Benign prostatic hyperplasia (BPH) is a multifactorial disease in which abnormal growth factor activation and embryonic reawakening are considered important factors. Here we demonstrated that the aberrant activation of transforming growth f...
NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma [0.03%]
NRN1通过与诺奖的相互作用增强黑色素瘤中的致癌信号转导及统计学3信号传导
Lucia Devitt,Dana Westphal,Katharina Pieger et al.
Lucia Devitt et al.
Background: Melanoma is a highly heterogeneous cancer, in which frequent changes in activation of signaling pathways lead to a high adaptability to ever changing tumor microenvironments. The elucidation of cancer specific...
E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα [0.03%]
E3连接酶RNF128通过促进IL-3RαK27位赖氨酸多泛素化抑制IL-3/STAT5信号通路
Jingge Yu,Jianguo Li,Ao Shen et al.
Jingge Yu et al.
IL-3/STAT5 signaling pathway is crucial for the development and activation of immune cells, contributing to the cellular response to infections and inflammatory stimuli. Dysregulation of the IL-3/STAT5 signaling have been associated with in...
Marco Cordani,Ilaria Dando,Giulia Ambrosini et al.
Marco Cordani et al.
Cancer's complexity is in part due to the presence of intratumor heterogeneity and the dynamic nature of cancer cell plasticity, which create substantial obstacles in effective cancer management. Variability within a tumor arises from the e...
DJ-1 preserves ischemic postconditioning-induced cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1 subcellular translocation [0.03%]
DJ-1保护STZ诱导的1型糖尿病大鼠缺血后处理的心肌保护作用：PTEN和DJ-1亚细胞易位的作用
Wei Li,Yan Leng,Yonghong Xiong et al.
Wei Li et al.
Background: Ischemic postconditioning (IPostC) has been reported as a promising method for protecting against myocardial ischemia-reperfusion (MI/R) injury. Our previous study found that the infarct-limiting effect of IPo...
Correction: High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer [0.03%]
纠正：高雌激素受体α表达与结直肠癌不良预后相关并促进转移
Geriolda Topi,Shakti Ranjan Satapathy,Souvik Ghatak et al.
Geriolda Topi et al.
Published Erratum
Cell communication and signaling : CCS. 2024 May 2;22(1):253. DOI:10.1186/s12964-024-01631-9 2024
Signaling controversy and future therapeutical perspectives of targeting sphingolipid network in cancer immune editing and resistance to tumor necrosis factor-α immunotherapy [0.03%]
针对癌症免疫编辑和抗肿瘤坏死因子α免疫治疗耐药性靶向鞘脂类网络的信号争议及未来治疗展望
Olga A Sukocheva,Margarita E Neganova,Yulia Aleksandrova et al.
Olga A Sukocheva et al.
Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) pathways. The pro-inflammatory cytokine TNF...
Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA [0.03%]
Helicobacter pylori中的两种显著的丝氨酸/亮氨酸多态性：对热休克蛋白HtrA和粘附素BabA的功能重要性
Steffen Backert,Nicole Tegtmeyer,Anselm H C Horn et al.
Steffen Backert et al.
Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobacter pylori. However, data on the effects of specific SNPs in pathogen-host interactions a...
Ying Feng,Zhibo Yang,Jianpeng Wang et al.
Ying Feng et al.
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress and dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known ce...
Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling [0.03%]
肿瘤衍生的SMAD4丢失通过BMP4信号增强原发性肿瘤生长但不影响转移
Lap Hing Chi,Andrew D Redfern,Suraya Roslan et al.
Lap Hing Chi et al.
Background: Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive. ...