The development of probiotics and prebiotics therapy to ulcerative colitis: a therapy that has gained considerable momentum [0.03%]
益生菌和益生元治疗溃疡性结肠炎的研究进展：一种迅速崛起的治疗方法
Jing Guo,Liping Li,Yue Cai et al.
Jing Guo et al.
Ulcerative colitis (UC) is increasingly common, and it is gradually become a kind of global epidemic. UC is a type of inflammatory bowel disease (IBD), and it is a lifetime recurrent disease. UC as a common disease has become a financial bu...
Integrins as the pivotal regulators of cisplatin response in tumor cells [0.03%]
整合素是肿瘤细胞顺铂反应的关键调节因子
Arya Nasimi Shad,Meysam Moghbeli
Arya Nasimi Shad
Cisplatin (CDDP) is a widely used first-line chemotherapeutic drug in various cancers. However, CDDP resistance is frequently observed in cancer patients. Therefore, it is required to evaluate the molecular mechanisms associated with CDDP r...
PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression [0.03%]
过氧化物酶体增殖激活受体γ激动剂活化ALDOC-NR2F1轴增强胶质母细胞瘤对替莫唑胺敏感性抑制肿瘤进展
Yu-Chan Chang,Ming-Hsien Chan,Chien-Hsiu Li et al.
Yu-Chan Chang et al.
Glioblastoma (GBM) is a type of brain cancer categorized as a high-grade glioma. GBM is characterized by limited treatment options, low patient survival rates, and abnormal serotonin metabolism. Previous studies have investigated the tumor ...
Integrin-linked kinase mRNA expression in circulating mononuclear cells as a biomarker of kidney and vascular damage in experimental chronic kidney disease [0.03%]
整合素连接激酶mRNA在循环单个核细胞中的表达作为实验性慢性肾脏病肾和血管损伤的生物标志物
Sofía Campillo,Elena Gutiérrez-Calabrés,Susana García-Miranda et al.
Sofía Campillo et al.
Background: Traditional biomarkers of chronic kidney disease (CKD) detect the disease in its late stages and hardly predict associated vascular damage. Integrin-linked kinase (ILK) is a scaffolding protein and a serine/th...
Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3 [0.03%]
幽门螺旋杆菌通过激活巨噬细胞分泌CCL3破坏胃粘膜稳态
Yan-Fei Wei,Xue Li,Meng-Ran Zhao et al.
Yan-Fei Wei et al.
Background: Helicobacter pylori (H. pylori) is the predominant etiological agent of gastritis and disrupts the integrity of the gastric mucosal barrier through various pathogenic mechanisms. After H. pylori invades the ga...
Emerging strategies for treating autoimmune disease with genetically modified dendritic cells [0.03%]
利用基因编辑的树突状细胞治疗自身免疫病的新策略
Yunhan Ma,Ruobing Shi,Fujun Li et al.
Yunhan Ma et al.
Gene editing of living cells has become a crucial tool in medical research, enabling scientists to address fundamental biological questions and develop novel strategies for disease treatment. This technology has particularly revolutionized ...
Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells [0.03%]
一种人IL-6受体α的小分子阻断多肽可抑制肿瘤细胞增殖和迁移
Yaroslava Groza,Lukáš Lacina,Milan Kuchař et al.
Yaroslava Groza et al.
Background: Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) ...
Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion [0.03%]
脱泛素酶：肿瘤微环境的潜在调节因子及其免疫逃逸机制意义
Sheng-Kai Hsu,Chon-Kit Chou,I-Ling Lin et al.
Sheng-Kai Hsu et al.
Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes (DUBs), a protein superfamily consisting of more than 100 members, deconjugate ubiquitin cha...
Outcomes of physical exercises on initiation, progression, and treatment of breast cancer [0.03%]
身体锻炼对乳腺癌的预防、发展和治疗的影响
Junwei Xu,Xiance Jiao,Reyhaneh Bayat
Junwei Xu
The emergence of drug resistance is a substantial obstacle to the effective management of breast cancer, which is the primary cause of cancer-related deaths in women worldwide. To facilitate the development of targeted therapies that can ef...
NCX1/Ca2+ promotes autophagy and decreases bortezomib activity in multiple myeloma through non-canonical NFκB signaling pathway [0.03%]
NCX1/钙离子促进多发性骨髓瘤非经典NF-κB信号途径介导的自噬并降低硼替佐米活性
Tingting Li,Pingping Xiao,Dongbiao Qiu et al.
Tingting Li et al.
Although bortezomib (BTZ) is the cornerstone of anti-multiple myeloma (MM) therapy, the inevitable primary and secondary drug resistance still seriously affects the prognosis of patients. New treatment strategies are in need. Sodium-calcium...