Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity [0.03%]
P21激活激酶1和4的抑制通过促进抗肿瘤免疫协同抑制胰腺癌生长
Yi Ma,Chelsea Dumesny,Li Dong et al.
Yi Ma et al.
Background: Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal types of cancer, and KRAS oncogene occurs in over 90% of cases. P21-activated kinases (PAK), containing six members (PAK1 to 6), function downst...
Yumeng Li,Xutong Tian,Juyue Luo et al.
Yumeng Li et al.
Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic d...
The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling [0.03%]
CD6互作蛋白网络调控配体非依赖性T细胞抑制信号转导
Rita F Santos,Annika de Sousa Linhares,Peter Steinberger et al.
Rita F Santos et al.
Background: T-cell membrane scaffold proteins are pivotal in T cell function, acting as versatile signaling hubs. While CD6 forms a large intracellular signalosome, it is distinguished from typical scaffolds like LAT or P...
APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition [0.03%]
APC/C调控的CPT1C通过上调能量供应和加速G1 / S转换促进肿瘤进程
Huihui Zhao,Xinxin Cheng,Liping Yan et al.
Huihui Zhao et al.
Background: In addition to functioning as a precise monitoring mechanism in cell cycle, the anaphase-promoting complex/cyclosome (APC/C) is reported to be involved in regulating multiple metabolic processes by facilitatin...
An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells [0.03%]
端粒酶反转录酶表达上调与树突状细胞免疫耐受破坏之间的关联研究
Xuejie Xu,Lihua Mo,Yun Liao et al.
Xuejie Xu et al.
Background: To elucidate the mechanism of dysfunction of tolerogenic dendritic cells (DCs) is of significance. Telomerase involves the regulation of the cell fate and activities. The objective of this study is to investig...
Extracellular vesicles promote migration despite BRAF inhibitor treatment in malignant melanoma cells [0.03%]
细胞外囊泡促进恶性黑色素瘤细胞迁移尽管使用BRAF抑制剂治疗
Afrodité Németh,Gréta L Bányai,Nikolett K Dobos et al.
Afrodité Németh et al.
Extracellular vesicles (EVs) constitute a vital component of intercellular communication, exerting significant influence on metastasis formation and drug resistance mechanisms. Malignant melanoma (MM) is one of the deadliest forms of skin c...
O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology [0.03%]
O-连接的N-乙酰葡萄糖胺（O-GlcNAc）化在骨生理病理中的作用及潜在治疗靶点
Xiaohan Yan,Jingjing Zheng,Wenhao Ren et al.
Xiaohan Yan et al.
O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O-GlcNAcylation levels are regulated by the activity of two enzymes, O-G...
Conversion of dendritic cells into tolerogenic or inflammatory cells depends on the activation threshold and kinetics of the mTOR signaling pathway [0.03%]
依赖于mTOR信号通路的活化阈值和动力学，树突状细胞向耐受性或炎症性细胞转化
Viktor Wixler,Yvonne Boergeling,Rafael Leite Dantas et al.
Viktor Wixler et al.
Background: Restoring impaired peripheral immune tolerance is the primary challenge in treating autoimmune diseases. Our previous research demonstrated the effectiveness of small spleen peptides (SSPs), a fraction of low ...
Metabolic self-feeding in HBV-associated hepatocarcinoma centered on feedback between circulation lipids and the cellular MAPK/mTOR axis [0.03%]
以循环脂质和细胞MAPK/mTOR轴之间的反馈作用为中心的乙肝相关肝癌代谢自养特性研究
Ying Zhu,Yingke Zhao,Zhouyu Ning et al.
Ying Zhu et al.
Introduction: Hepatitis B Virus (HBV) is widely recognized as a "metabolic virus" that disrupts hepatic metabolic homeostasis, rendering it one of the foremost risk factors for hepatocellular carcinoma (HCC). Except for a...
Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB [0.03%]
角鲨烯环氧酶通过(S)-2,3-环氧角鲨烯激活的NF-κB促进结直肠癌耐药性
Qi Liu,Yajuan Zhang,Huimin Li et al.
Qi Liu et al.
Background: While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood. ...