SATB2 dysregulation generates a novel circular RNA and drives KRAS-like transcriptional reprogramming and transformation-associated phenotypes [0.03%]
SATB2 表达失调生成新型环状RNA并驱动KRAS样转录重编程和转化相关表型
Rebekah Eleazer,Smitha George,Luke J Shoemaker et al.
Rebekah Eleazer et al.
Background: Even though epigenetic factors contribute to oncogenesis, most human cancer models still assume that disease originates from driver DNA mutations. Thus, it is still unclear if non-genetic mechanisms are suffic...
A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence [0.03%]
由FERMT3编码的微蛋白调节内皮细胞蛋白质分解代谢并诱导细胞周期停滞和衰老
Manav Raheja,Beyza Güven,Witold Szymanski et al.
Manav Raheja et al.
Background: Endothelial cells express numerous microproteins (miPs) encoded by small open reading frames (smORFs), yet the biological function of most remains unknown. This study set out to characterize a novel 69 amino a...
MARVELD1 regulates hepatocyte transformation via maintaining NF-κB signaling homeostasis mediated by the CCL5/CCR5 axis between hepatic stellate cells and hepatocytes [0.03%]
MARVELD1通过维持肝星状细胞和肝细胞之间CCL5/CCR5轴介导的NF-κB信号稳态来调节肝细胞转化
Muhammad Luqman Akhtar,Haoxiu Sun,Liangyu Cao et al.
Muhammad Luqman Akhtar et al.
Background: Hepatocellular carcinoma (HCC) involves abnormal alterations in cellular homeostasis regulation and molecular crosstalk between hepatic stellate cells (HSCs) and hepatocytes, and the underlying mechanisms are ...
Glucose transport dependency defines a therapeutic vulnerability in JAK2V617F-driven myeloproliferative neoplasms [0.03%]
葡萄糖转运依赖性界定了JAK2V617F驱动的髓系增生性肿瘤的治疗弱点
Patrick Weiand,Nicolas Chatain,Marcelo A Szymanski de Toledo et al.
Patrick Weiand et al.
Background: Myeloproliferative neoplasms (MPN) comprise a heterogenous group of hematological malignancies that include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Current ther...
Structural insights into the specificity of adaptor proteins Dok5 and Dok6 Docking to Trk receptors [0.03%]
Trk受体与衔接蛋白Dok5和Dok6的特异性相互作用机制的结构研究
Yingyao Wu,Xiaojiao Sun,Hongyue Chen et al.
Yingyao Wu et al.
Specific neurotrophic signaling by Trk receptors relies on the selective recruitment of downstream adaptors such as Dok5 and Dok6, yet the structural basis underlying this selectivity has remained unresolved. Here, we elucidate the principl...
Mitochondria-associated endoplasmic reticulum membrane (MAM): roles in innate immunity dysregulation [0.03%]
线粒体相关内质网膜(MAM)在天然免疫失调中的作用
Qingqi Zhang,Junyan Gao,Yiting Yang et al.
Qingqi Zhang et al.
Mitochondria-associated endoplasmic reticulum membrane (MAM), which serves as a signaling hub for interactions between the endoplasmic reticulum (ER) and mitochondria, dynamically coordinates innate immune processes by regulating calcium ho...
Francesco De Giorgio,Luca Munaron,Emanuela Tolosano et al.
Francesco De Giorgio et al.
Heme is an essential iron-containing porphyrin of vital importance for all cells, including endothelial cell (EC). Indeed, due to its involvement in several biological processes, including gene transcription regulation, energy production, a...
Circadian rhythm of dendritic cells directs the time-dependent efficacy of photodynamic therapy [0.03%]
树突细胞的昼夜节律决定光动力治疗的效果变化规律
Rui Zhang,Sihan Dong,Yinghao Zheng et al.
Rui Zhang et al.
Background: While cancer treatment efficacy exhibits circadian differences, the role of circadian rhythms in photodynamic therapy (PDT) remains unclear. Understanding this relationship is crucial for treatment optimizatio...
How post-translational modifications impact glucocorticoid receptor function in human pathologies [0.03%]
泛素化修饰对糖皮质激素受体功能及人类疾病的影响机制研究
Zélie Bouveret,Ludivine Pruvost,Olivier Trédan et al.
Zélie Bouveret et al.
Glucocorticoid receptor (GR) is a member of the nuclear hormone receptor family, which acts as a transcription factor when bound by glucocorticoid (GC) ligands. GR is expressed in nearly all tissue types and regulates essential processes su...
Retinoic acid as a stage-specific modulator of hematopoietic lineage fate from human pluripotent stem cells [0.03%]
视黄酸通过调节人多能干细胞的造血谱系命运起到阶段特异性调节因子的作用
Seo-Hyun An,Ji-Yeon Kim,Ying-Ying Mao et al.
Seo-Hyun An et al.
Retinoic acid (RA), a bioactive metabolite of vitamin A, plays roles in early embryogenesis and hematopoietic development. However, its precise function in directing the hematopoietic lineage outcomes of human pluripotent stem cells (hPSCs)...