Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis [0.03%]
Gasdermin D缺乏通过驱动狼疮性肾炎中粒细胞生成来终止髓系钙离子流入
Jiani Shen,Feng Li,Xu Han et al.
Jiani Shen et al.
Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly elevated GSDMD in human and mouse LN kidneys, predominantly in CD1...
NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression [0.03%]
NEDD4L介导ITGB4泛素化及降解抑制食管癌进展
Yijun Shi,Na Fang,Yutong Wu et al.
Yijun Shi et al.
The ubiquitination-mediated protein degradation exerts a vital role in the progression of multiple tumors. NEDD4L, which belongs to the E3 ubiquitin ligase NEDD4 family, is related to tumor genesis, metastasis and drug resistance. However, ...
ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity [0.03%]
内质网压力抑制增强三酰甘油的形成并保护内皮细胞免受脂毒性侵害
Igor Kovacevic,Paula Henriette Schmidt,Annkatrin Kowalski et al.
Igor Kovacevic et al.
Elevated concentrations of palmitate in serum of obese individuals can impair endothelial function, contributing to development of cardiovascular disease. Although several molecular mechanisms of palmitate-induced endothelial dysfunction ha...
GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma [0.03%]
GLUT1通过与表皮生长因子受体磷酸化形式结合并稳定其在肺腺癌中促进细胞增殖
Zhiqing Zhou,Yu Li,Sijie Chen et al.
Zhiqing Zhou et al.
Background: While previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to discover if GLUT1 promotes tumor progression through a non-metabolic pathway....
Interleukin-22 receptor 1-mediated stimulation of T-type Ca2+ channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway [0.03%]
白细胞介素22受体1通过淋巴细胞酪蛋白激酶Lyn依赖型蛋白激酶A通路调节瞬时受体电位V族3通道活化增强伤害性感觉神经元兴奋性
Hua Cai,Siyu Chen,Yufang Sun et al.
Hua Cai et al.
Background: Interleukin 24 (IL-24) has been implicated in the nociceptive signaling. However, direct evidence and the precise molecular mechanism underlying IL-24's role in peripheral nociception remain unclear. ...
STING agonists as promising vaccine adjuvants to boost immunogenicity against SARS-related coronavirus derived infection: possible role of autophagy [0.03%]
STING激动剂有望作为疫苗佐剂以增强对SARS相关冠状病毒衍生感染的免疫原性：自噬可能起到一定作用
Aysa Rezabakhsh,M Reza Sadaie,Alireza Ala et al.
Aysa Rezabakhsh et al.
As a major component of innate immunity and a positive regulator of interferons, the Stimulator of interferon gene (STING) has an immunotherapy potential to govern a variety of infectious diseases. Despite the recent advances regarding vacc...
Human amnion mesenchymal stem cells promote endometrial repair via paracrine, preferentially than transdifferentiation [0.03%]
人胎盘羊膜间充质干细胞通过旁分泌促进子宫内膜修复的作用优于转分化作用
Xiyue Huang,Xiao Yang,Jinglin Huang et al.
Xiyue Huang et al.
Background: Intrauterine adhesion (IUA) is one of the most severe causes of infertility in women of childbearing age with injured endometrium secondary to uterine performance. Stem cell therapy is effective in treating da...
Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis [0.03%]
低浓度saracatinib通过抑制FAK-YAP信号轴促进确定性内胚层分化
Ruiyang Ma,Huanjing Bi,Ying Wang et al.
Ruiyang Ma et al.
Optimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the generation of diverse organ-like structures. In this study, we used the small molecule inhibitor saracatinib (SAR) to enhance DE differentiation of h...
Deciphering the dual nature of nesfatin-1: a tale of zinc ion's Janus-faced influence [0.03%]
解开nesfatin-1的双重性质：锌离子的矛盾作用机制的故事
Rafał Lenda,Lilia Zhukova,Andrzej Ożyhar et al.
Rafał Lenda et al.
Background: Nucleobindin-2 (Nucb2) and nesfatin-1 (N1) are widely distributed hormones that regulate numerous physiological processes, from energy homeostasis to carcinogenesis. However, the role of nesfatin-2 (N2), the s...
Ephs in cancer progression: complexity and context-dependent nature in signaling, angiogenesis and immunity [0.03%]
Ephs在癌症进展中的作用：信号传导、血管生成和免疫应答的复杂性和依赖性
Xiaoting Guo,Yanyi Yang,Jingqun Tang et al.
Xiaoting Guo et al.
Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiological processes, accumulating evid...