Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis [0.03%]
生长因子受体依赖性信号的昼夜节律及其对肿瘤发生的影响
Emanuele Murgo,Giorgia Falco,Gaetano Serviddio et al.
Emanuele Murgo et al.
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and membrane-bound enzyme-linked receptors, such as receptor tyrosine kinases and serine-threonine...
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases [0.03%]
治异疗法：活性氧依赖的NLRP3炎性小体介导的疾病治疗中的染料木素效应研究
Wenhao Liao,Yuchen Li,Jingwen Liu et al.
Wenhao Liao et al.
Background: Aberrant inflammatory responses drive the initiation and progression of various diseases, and hyperactivation of NLRP3 inflammasome is a key pathogenetic mechanism. Pharmacological inhibitors of NLRP3 represen...
The FABD domain is critical for the oncogenicity of BCR/ABL in chronic myeloid leukaemia [0.03%]
FABD结构域对慢性髓性白血病中BCR/ABL致癌性至关重要
Renren Zheng,Wei Wei,Suotian Liu et al.
Renren Zheng et al.
Background: Abnormally expressed BCR/ABL protein serves as the basis for the development of chronic myeloid leukaemia (CML). The F-actin binding domain (FABD), which is a crucial region of the BCR/ABL fusion protein, is a...
Correction: Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells [0.03%]
关于：子痫前期通过向系膜内皮细胞递送胎盘衍生的外泌体阻碍胎儿肾脏发育的更正公告
Mengqi Gu,Pengzheng Chen,Dongmei Zeng et al.
Mengqi Gu et al.
Published Erratum
Cell communication and signaling : CCS. 2024 Jun 7;22(1):316. DOI:10.1186/s12964-024-01697-5 2024
Altered glia-neuron communication in Alzheimer's Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq [0.03%]
阿尔茨海默病中改变的胶质细胞-神经元通讯影响WNT，p53和NFkB信号通路（由snRNA测序确定）
Tabea M Soelter,Timothy C Howton,Amanda D Clark et al.
Tabea M Soelter et al.
Background: Alzheimer's disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. Although neuronal loss is a primary hallmark of Alzheimer's ...
Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis [0.03%]
整合素αVβ1活化的PYK2通过STAT3-VGF轴促进非小细胞肺癌进展
Zhengyan Wu,Min Jiao,Chenying Shu et al.
Zhengyan Wu et al.
Background: Non-small-cell lung cancer (NSCLC) accounts for 80-85% of all lung cancer and is the leading cause of cancer-related deaths globally. Although various treatment strategies have been introduced, the 5-year surv...
Correction: Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2 [0.03%]
订正：内皮穆司林通过与AP2的相互作用特异性地调节血管内皮生长因子受体-2的内吞作用
Issahy Cano,Melissa Wild,Urvi Gupta et al.
Issahy Cano et al.
Published Erratum
Cell communication and signaling : CCS. 2024 Jun 6;22(1):311. DOI:10.1186/s12964-024-01696-6 2024
LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors [0.03%]
LKB1生物学：评估LKB1抑制剂的治疗相关性
Charles B Trelford,Trevor G Shepherd
Charles B Trelford
Liver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 (STK11), is a master kinase that regulates cell migration, polarity, proliferation, and metabolism through downstream adenosine monophosphate-activated protein kinase (AMPK) and ...
A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo [0.03%]
橄榄素是一种罕见的橄榄化合物，可作为TrkB激动剂并减轻体内和体外的神经炎症作用
Daiki Wakasugi,Shinji Kondo,Farhana Ferdousi et al.
Daiki Wakasugi et al.
Background: Neuroinflammation is widely acknowledged as a characteristic feature of almost all neurological disorders and specifically in depression- and anxiety-like disorders. In recent years, there has been significant...
Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF [0.03%]
活化AMPK通过PCAF使H3K9高乙酰化来抑制宫颈癌生长
Botao Pan,Can Liu,Jiyan Su et al.
Botao Pan et al.
Background: Dysregulation in histone acetylation, a significant epigenetic alteration closely associated with major pathologies including cancer, promotes tumorigenesis, inactivating tumor-suppressor genes and activating ...