BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo [0.03%]
BI-2865（一种泛KRAS抑制剂）逆转体内外P-糖蛋白诱导的多药耐药性
Qihong Yang,Kenneth Kin Wah To,Guilin Hu et al.
Qihong Yang et al.
Background: Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will in...
Correction: Human amnion mesenchymal stem cells promote endometrial repair via paracrine, preferentially than transdifferentiation [0.03%]
纠正：人胎盘羊膜间充质干细胞通过旁分泌促进子宫内膜修复而非跨分化优先
Xiyue Huang,Xiao Yang,Jinglin Huang et al.
Xiyue Huang et al.
Correction: Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF [0.03%]
订正：活化的AMPK通过PCAF使H3K9高乙酰化从而抑制宫颈癌生长
Botao Pan,Can Liu,Jiyan Su et al.
Botao Pan et al.
Mitochondrial DNA release via the mitochondrial permeability transition pore activates the cGAS-STING pathway, exacerbating inflammation in acute Kawasaki disease [0.03%]
线粒体过渡孔介导的线粒体DNA释放激活cGAS-STING信号通路加重急性川崎病炎症反应
Ke Wei,Tao Chen,Hao Fang et al.
Ke Wei et al.
Background: Kawasaki disease (KD) is an immune vasculitis of unknown origin, characterized by transient inflammation. The activation of the cGAS-STING pathway, triggered by mitochondrial DNA (mtDNA) release, has been impl...
Podoplanin depletion in tonsil-derived mesenchymal stem cells induces cellular senescence via regulation of the p16Ink4a/Rb pathway [0.03%]
podoplanin通过调控p16ink4a/rb通路诱导来源于扁桃体间充质干细胞的细胞衰老
Ha Yeong Kim,Han Su Kim
Ha Yeong Kim
Background: Mesenchymal stem cells (MSCs) are widely used in the development of therapeutic tools in regenerative medicine. However, their quality decreases during in vitro expansion because of heterogeneity and acquired ...
KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination [0.03%]
基于 tepotinib 和奥美拉唑联合疗法的 KRAS 突变非小细胞肺癌(NSCLC)治疗
Rafael Rosell,Eloisa Jantus-Lewintre,Peng Cao et al.
Rafael Rosell et al.
Background: KRAS-mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS-G12C selective inhibitors, leading to short median progression-free survival, and ove...
Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation [0.03%]
ADAM10或ADAM17下调可促进破骨细胞分化
Aaron Babendreyer,Julia Kieselhorst,Cindy Rinkens et al.
Aaron Babendreyer et al.
Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-Β ligand (RANKL). We noted that a disintegrin and metalloproteinase (ADAM) 10 and A...
Motor skill learning modulates striatal extracellular vesicles' content in a mouse model of Huntington's disease [0.03%]
运动技能学习调节亨廷顿舞蹈病小鼠模型纹状体细胞外囊泡的内容物
Júlia Solana-Balaguer,Pol Garcia-Segura,Genís Campoy-Campos et al.
Júlia Solana-Balaguer et al.
Huntington's disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene (HTT). HD pathology mostly affects striatal medium-sized spiny neurons and results in an altered cortico-striatal function. Recent studies...
Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy [0.03%]
靶向MM的mTOR信号途径：生物学特性与治疗意义
Yanmeng Wang,Niels Vandewalle,Kim De Veirman et al.
Yanmeng Wang et al.
Multiple Myeloma (MM), a cancer of terminally differentiated plasma cells, is the second most prevalent hematological malignancy and is incurable due to the inevitable development of drug resistance. Intense protein synthesis is a distincti...
The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating β-catenin [0.03%]
IL-33-ST2轴通过磷酸化β-连环蛋白促进上皮间质转化在子宫内膜异位症中起重要作用
Jingyao Ruan,Qi Tian,Siting Li et al.
Jingyao Ruan et al.
Objectives: Interleukin 33 (IL-33) is a crucial inflammatory factor that functions as an alarm signal in endometriosis (EMs). Epithelial-mesenchymal transition (EMT), a process related to inflammatory signals, intracellul...