Targeting AIF to trigger RIPKs/MLKL necroptosis: a disulfiram-based strategy to reverse paclitaxel resistance in ovarian cancer [0.03%]
二硫辛醇通过诱导线粒体介导的坏死性凋亡克服卵巢癌紫杉醇耐药性的研究
Jiaofeng Li,Wei Zhou,Hualong Tang et al.
Jiaofeng Li et al.
Objective: Paclitaxel is a cornerstone first-line therapy for ovarian cancer, but its efficacy is limited by chemoresistance. Disulfiram (DSF), an FDA-approved alcohol-aversion drug, shows promising antitumor activity. Ho...
Compositional recalibrations of cardiolipin integrate loss of stearoyl-CoA desaturase 1 activity with mitochondrial decay in lipid-laden pancreatic β-cells [0.03%]
脂质积聚的胰岛β细胞中,缺少硬脂酰辅酶a去饱和酶1活性与线粒体衰老通过卵磷脂相互整合
Justyna Janikiewicz,Magdalena Lebiedzinska-Arciszewska,Maria E Kendziorek et al.
Justyna Janikiewicz et al.
Type 2 diabetes (T2D) is driven by pancreatic β-cell failure, often in the metabolic context of overweight, obesity, and systemic insulin resistance. Importantly, the accumulation of excess lipids in the pancreas accelerates mitochondrial ...
A bispecific-aptamer TSHR-CD80-1 treats thyroid eye disease by inhibiting CD8+ T cell-fibroblast interactions [0.03%]
一种双特异性适体TSHR-CD80-1通过抑制CD8+T细胞-成纤维细胞相互作用治疗甲状腺眼病
Jiamin Cao,Zhaochangci Chen,Lemeng Feng et al.
Jiamin Cao et al.
Thyroid eye disease (TED), an autoimmune disorder, involves critical interactions among immune cells that drive disease progression. However, the underlying mechanisms and their therapeutic potential remain unclear. This study profiled leuk...
Programmable aging function-related mitochondrial DNA 5-methylcytosine (m5C) modification with a TALE-directed methyltransferase [0.03%]
TALE导向的甲基转移酶介导的线粒体DNA上与可编程衰老功能相关的5-胞嘧啶甲基化(m5C)修饰
Guo Li,Xinzhi Zhou,Guanglin Zhu et al.
Guo Li et al.
Mitochondrial epigenetic editing offers a potential strategy for modulating disease-causing mitochondrial genes while leaving the underlying DNA sequence unchanged. In this study, we present MEE, a mitochondrial epigenetic editor consisting...
PIGBOS-CLCC1 interaction shapes cellular calcium dynamics and energy metabolism [0.03%]
PIGBOS-CLCC1相互作用调节细胞钙信号和能量代谢
Seemanti Aditya,Amal Kanti Bera
Seemanti Aditya
PIGBOS is a recently identified 54-amino acid microprotein localized to the mitochondrial outer membrane and implicated in the endoplasmic reticulum (ER) stress response. Here, we identify a previously unrecognized role for PIGBOS in cellul...
Patronin facilitates neurite remodeling via epithelial-to-neuronal signaling [0.03%]
Patronin通过上皮到神经元信号传导促进神经突重塑
Wanyue Xu,Su Wang,Xinting Lv et al.
Wanyue Xu et al.
During development, the formation of precise neuronal connections and the refinement of neural circuits involves neurite pruning, a process that eliminates superfluous axons and dendrites without losing their parental cells. In Drosophila, ...
Amino-acids-mTORC1-driven DDA1 phosphorylation promotes DNA repair and glioblastoma progression [0.03%]
氨基酸-mTORC1驱动的DDA1磷酸化促进DNA修复和胶质母细胞瘤进展
Xing Chen,Zhixing Wang,An Yan et al.
Xing Chen et al.
Background: DDA1 is a protein involved in protein degradation, cell cycle regulation, and DNA damage repair. Although its expression varies across tumor types, the precise role of DDA1 in gliomagenesis remains unclear. ...
Avian Foxp3 acts as a switch for IL-10 by directly binding the T3G motif: revealing a novel epigenetic modulation paradigm [0.03%]
鸟类Foxp3通过直接结合T3G基序充当IL-10的开关：揭示了一种新的表观遗传调控范例
Tianxu Li,Shouwen Du,Yaxin Wu et al.
Tianxu Li et al.
Background: Foxp3 is the master transcription factor for regulatory T (Treg) cell differentiation and function, essential for immune homeostasis and tolerance. While its role is well-characterized in mammals, its function...
Saihao Wang,Yan Wang,Ting Zhao et al.
Saihao Wang et al.
tRNAs, one of the most conserved and abundant RNAs, are central components of protein synthesis, transferring genetic information from DNA to proteins through a precise base-pairing mechanism. Post-transcriptional modifications of tRNAs by ...
Bacterial extracellular vesicles modulate epithelial antiviral responses via macrophage-mediated immunomodulation [0.03%]
细菌外泌体通过巨噬细胞介导的免疫调节来调节上皮细胞的抗病毒反应
Jeff Bierwagen,Mosche Lückhof,Miriam Ruth Heindl et al.
Jeff Bierwagen et al.
Bacterial extracellular vesicles (bEVs) are nano-sized, mostly spherical, double-membrane structures secreted by bacteria throughout their life cycle. In addition to their role in many prokaryotic processes, they can interact with cells of ...