Gut microbiota-derived extracellular vesicles: bridging microbial-host crosstalk in metabolic disorders [0.03%]
肠道微生物衍生的外泌体：代谢紊乱中微生物与宿主互作的桥梁作用
Kaile Ma,Qiqi Zhang,Zishan Jin et al.
Kaile Ma et al.
Gut microbiota-derived extracellular vesicles have emerged as crucial mediators in microbe-host communication, not only facilitating intracellular communication, quorum sensing, and horizontal gene transfer among bacteria but also playing a...
Persistent NET states link lesion-related microbial signals to the cold tumor-related local restrictive environment: a context-dependent working model [0.03%]
持久性NET状态将与病灶相关的微生物信号链接到冷肿瘤相关局部限制性环境：一种上下文依赖的工作模型
Fanying Meng,ZhenLim Wong,Junyi Chen et al.
Fanying Meng et al.
Cold tumors often show poor effector immune cell entry or impaired effector function and therefore respond poorly to immunotherapy. Growing evidence suggests that neutrophil extracellular traps (NETs) are not simply by-products of tumor-ass...
R-loops and D-loops: a delicate balance in genomic stability and instability [0.03%]
R-loop和D-loop：基因组稳定与不稳定的微妙平衡
Zhendong Qin,Mingjun Lu,Jiaqi Zhao et al.
Zhendong Qin et al.
R-loops and D-loops are three-stranded nucleic acid structures that have emerged as central regulators of genome stability, gene expression, and DNA metabolism. R-loops form co-transcriptionally or post-transcriptionally when nascent RNA re...
Systematic AI-assisted screening of the cadhesome to map epithelial monolayer mechanics [0.03%]
系统性人工智能辅助筛选粘附斑蛋白素以绘制上皮单层力学图谱
Cristina Bertocchi,Juan José Alegría,Sebastián Vásquez-Sepúlveda et al.
Cristina Bertocchi et al.
Cadherin-mediated adhesions serve as key mechanical and signaling hubs in epithelial tissues, linking the actin cytoskeleton of adjacent cells. Their disruption is a hallmark of cancer progression. The "cadhesome" network comprises over 170...
Crosstalk collapse: mitochondria-centric organelle network disruption in ovarian aging [0.03%]
卵子老化中以线粒体为中心的细胞器网络退化现象
Wenhan Ju,Binghan Yan,Danping Li et al.
Wenhan Ju et al.
Ovarian aging defines the reproductive lifespan of females and exerts profound systemic effects on metabolism and overall health. However, its molecular basis remains incompletely understood. Traditional research has focused primarily on mi...
STIM-Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity [0.03%]
神经元中的STIM-Orai信号转导：整合钙离子动态变化和突触可塑性
Joanna Gruszczynska-Biegala
Joanna Gruszczynska-Biegala
Precise regulation of intracellular calcium signaling is essential for neuronal function and depends on tightly coordinated molecular mechanisms. Among them, endoplasmic reticulum-plasma membrane (ER-PM) junctions form dynamic signaling mic...
Qingyue Wang,Hang Xu,Xin Ding et al.
Qingyue Wang et al.
Background: Necroptosis is a regulated form of cell death mediated by the RIPK1/RIPK3-MLKL pathway. In humans, caspase (CASP) 8 negatively regulates the necroptotic pathway by inactivating RIPK1 and RIPK3. In teleosts and...
Integration of breaking-point transition probabilities and specific open chromatin region features for early cancer detection [0.03%]
结合临界点转移概率和特定开放染色质区域特征进行早期癌症检测
Jinwen Ji,Ke Xu,Yanru Li et al.
Jinwen Ji et al.
Background: Early detection of cancer using cell-free DNA (cfDNA) remains challenging due to the limited release of circulating tumor DNA (ctDNA) in early-stage disease. This study aimed to enhance detection sensitivity b...
A pan-cancer single-cell atlas uncovers the role of sex hormones and chromosomes in sex-divergent reprogramming of the tumor microenvironment [0.03%]
泛癌症单细胞图谱揭示性激素和性染色体在肿瘤微环境中重新编程的性别分化作用
Zhenyu Luo,Haoran Shi,Yingyi Shan et al.
Zhenyu Luo et al.
Background: Sex bias is pervasive in tumors; however, how sex chromosomes and hormone-responsive signaling shape the tumor microenvironment (TME) remains insufficiently characterized. Considering the critical impact of th...
HIV Tat-activated microglial extracellular vesicles induce neuronal iron dysregulation and synaptodendritic injury [0.03%]
HIV唐氏活化的小胶质细胞外泌体诱导神经元铁代谢紊乱和突触/树突损伤
Uma Maheswari Deshetty,Frida L Martínez-Cuevas,Poojashree Chettiar et al.
Uma Maheswari Deshetty et al.
Extracellular vesicles (EVs) are membrane-enclosed, nanoscale structures released by cells and play a key role in intercellular communication under both normal physiological and pathological conditions. They serve as conduits for transferri...