Glutamate accumulation in myelofibrosis microenvironment rewires mesenchymal stromal cells metabolic and epigenetic profiles [0.03%]
谷氨酸在骨髓纤维化微环境中的积累重塑了间充质基质细胞的代谢和表观遗传特征
Sebastiano Giallongo,Lucia Longhitano,Cesarina Giallongo et al.
Sebastiano Giallongo et al.
Background: Myelofibrosis (MF) is a clonal myeloproliferative neoplasm characterized by bone marrow (BM) fibrosis, osteosclerosis, and a proinflammatory tumor microenvironment (TME). The interplay between malignant hemato...
Molecular switches in cell death: the interplay of apoptosis and pyroptosis in cancer [0.03%]
细胞死亡中的分子开关：癌症中凋亡与焦亡的相互作用
Yanfang Liu,Yi Xie
Yanfang Liu
Programmed cell death in cancer encompasses apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy-dependent cell death and other interconnected programs. Within this broader landscape, apoptosis and pyroptosis are especially important ...
Calcium signaling in human and mouse microglia exhibit differential susceptibility to phytocannabinoids [0.03%]
人和小鼠的小胶质细胞对植物大麻素的钙信号反应具有不同的敏感性
Ivana Pilchova,Andrea Fleig,Reinhold Penner
Ivana Pilchova
Background: Neurological disorders affect over 40% of the global population and are driven in part by microglia-mediated neuroinflammation that depends on calcium (Ca²⁺) signaling. Cannabis-derived compounds (CBx) modul...
Usnic acid inhibits colorectal cancer liver metastasis by targeting CRYAB phosphorylation and inducing ferroptosis [0.03%]
乌术酸通过靶向CRYAB磷酸化并诱导铁死亡来抑制结直肠癌肝转移
Ziyuan Wan,Tingting Chen,Xiaotong Xu et al.
Ziyuan Wan et al.
Background: Colorectal cancer liver metastasis (CCLM) presents a significant challenge in oncology, characterized by aggressive progression and poor prognosis. Usnic acid (UA), a secondary metabolite derived from the lich...
Terahertz wave stimulation improves visual recognition memory via the activation of excitatory neurons in the perirhinal cortex [0.03%]
太赫兹波刺激通过旁海马区兴奋性神经元的激活来改善视觉识别记忆
Hui Wang,Zhiwei He,Lequan Song et al.
Hui Wang et al.
Terahertz (THz) waves, with frequencies between those of microwaves and infrared light, can excite nonlinear resonance and affect cellular function. However, the effects and underlying mechanism of terahertz radiation on neurons and rodent ...
Specific bile acids can elicit the type-I interferon response through the cGAS-STING pathway [0.03%]
特定胆酸可以通过cGAS-STING途径激发I型干扰素反应
Jianan He,Ziyan Huang,Caiwan Xiong et al.
Jianan He et al.
Bile acids are metabolites crucial to lipid metabolism and immune regulation, yet their biological functions and mechanistic underpinnings remain largely elusive. In this study, we demonstrate that specific bile acids DCA, CDCA and LCA can ...
Distinct roles of AdipoR1 and AdipoR2 in modulating neuronal firing homeostasis in response to adiponectin and AdipoRon [0.03%]
脂联素及其受体激动剂通过ADIPOR1和ADIPOR2调节神经元稳态放电的差异作用机制研究
Xiaoli Jia,Chengyou Zheng,Qichao Gong et al.
Xiaoli Jia et al.
Background: The regulation of neuronal network activity depends on interactions between intrinsic circuit mechanisms and metabolic signals. Adiponectin (APN) is a peripheral adipokine whose receptors are present in the ce...
GSK'872 mitigates ischemia-reperfusion injury in rat lung transplants by regulating PANoptosis and inflammation in cell type specific manner [0.03%]
GSK'872通过调节细胞类型特异性PANoptosis和炎症减轻大鼠肺移植中的缺血再灌注损伤
Jinsheng Li,Xingjie Ma,Jinghao Huang et al.
Jinsheng Li et al.
Background: Ischemia-reperfusion injury (IRI) greatly impairs lung transplantation (LTx) outcomes, with no effective treatments. Although existing studies have confirmed that cell death and inflammation responses are crit...
Sex differences in non-reproductive cancers: mechanistic roles of sex-hormone signaling [0.03%]
性别差异与非生殖系统癌症：性激素信号机制作用
Jingsheng Xu,Xinyu Zhang,Zhenyu Li et al.
Jingsheng Xu et al.
Sex differences in the incidence and outcomes of non-reproductive cancers persist across many tumor types, even after adjustment for major exposure- and care-related factors. This review examines how sex-hormone signaling may contribute to ...
SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor [0.03%]
SHP2通过使TGF-βI型受体去稳定化而负调控TGF-β信号转导路径
Cen Zhao,Ihor Yakymovych,Mariya Yakymovych et al.
Cen Zhao et al.
Background: SRC homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), acting as a central node of many signaling pathways, has an emerging role in many diseases, including cancer. Transforming growth factor ...