DEPDC7 couples homologous chromosome segregation to asymmetric cytokinesis through recruiting ARP2/3 complex in oocyte meiosis [0.03%]
DEPDC7通过募集ARP2/3复合物在卵母细胞减数分裂中将同源染色体分离与不对称胞质分裂偶联起来
Jia-Ni Guo,Si-Min Sun,Xue-Mei Yang et al.
Jia-Ni Guo et al.
During mammal meiosis, proper cytokinesis is essential for oocyte maturation. This process depends on actin cap formation and cortical polarity establishment. In this study, we reported that DEP domain-containing protein 7 (DEPDC7) function...
Dual targeting of interlocked PTK2B and MAPK signaling triggers synergistic ferroptosis via autophagic flux disruption in BRAFV600E glioma [0.03%]
双靶向PTK2B和MAPK信号诱导自噬流紊乱触发铁死亡协同抑制BRAFV600E胶质瘤
Min Wang,Chengyan Xu,Shanshan Xie et al.
Min Wang et al.
Background: BRAFV600E mutation is one of the most common oncogenic drivers in gliomas, sharing the highest incidence in pediatric low-grade gliomas (~ 20%) and being frequently associated with poor prognosis. Although com...
Repurposed anticancer drugs disrupt cancer-like traits of Theileria annulata and suppress Leishmania donovani [0.03%]
抗肿瘤药物再利用可干扰安氏泰勒虫的癌变特性并抑制唐氏利什曼原虫
Samoel Lareb,Madhusmita Subudhi,Akash Suresh et al.
Samoel Lareb et al.
Protozoan parasites remain a major threat to global health, affecting both humans and livestock. Theileria annulata, an apicomplexan parasite of cattle, transforms host leukocytes into a cancer-like state, while Leishmania donovani causes v...
Crosstalk of noradrenergic Ca2+ and cAMP signaling in astrocytes of the murine olfactory bulb [0.03%]
小鼠嗅球星形胶质细胞去甲肾上腺素Ca2+和cAMP信号串扰
Jessica Sauer,Antonia Beiersdorfer,Franz Lennart Schmidt et al.
Jessica Sauer et al.
Cyclic adenosine monophosphate (cAMP) and Ca²⁺ are ubiquitous second messengers that regulate gene expression, metabolism, and synaptic plasticity. Here, we identified a complex interplay between Ca²⁺ and cAMP signaling pathways in mous...
S100A4 promotes collective invasion of pancreatic ductal adenocarcinoma and its blockade suppresses metastasis [0.03%]
S100A4促进胰腺导管腺癌的集体侵袭及其阻断可抑制转移
Dong Woo Son,Ye-Jin Lim,Chae Won Yu et al.
Dong Woo Son et al.
Most solid tumors invade peritumoral tissues as multicellular units while maintaining cell-cell interactions and epithelial characteristics, a process known as collective invasion. Our previous proteomic analysis revealed that S100-family p...
8-gingerol from Zingiber officinale induces ER stress-mediated ferroptosis and apoptosis in ovarian cancer involving TRPV1 activation [0.03%]
从姜黄中提取的八姜酚通过瞬时受体电位香草素1激活诱导内质网应激介导的铁死亡和卵巢癌中的凋亡
Tae Woo Kim
Tae Woo Kim
Background: Ovarian cancer remains among the most lethal gynecological malignancies, primarily due to the persistent challenges of chemotherapy resistance and limited effectiveness of existing therapeutic strategies. ...
Home-based high-intensity exercise training during neoadjuvant chemotherapy is associated with favorable chemotherapy outcomes and tumor microenvironment remodeling in breast cancer [0.03%]
居家高强度锻炼与乳腺癌新辅助化疗的良好疗效及肿瘤微环境重塑相关性研究
Diana Skorinkina,Kristaps Eglītis,Pawel Zayakin et al.
Diana Skorinkina et al.
Background: A growing number of studies show that physical exercise is feasible and safe for cancer patients and enhances various physical and cognitive capabilities, thus improving the quality of life and disease outcome...
Stress-induced CD55 supports homologous recombination capacity and drives oxaliplatin resistance in colorectal cancer [0.03%]
应激诱导的CD55促进同源重组修复并驱动结直肠癌患者顺铂耐药性产生
Tianyang Wang,Xiaoyan Zhang,Xiaocan Yan et al.
Tianyang Wang et al.
Background: Acquired resistance to oxaliplatin limits the efficacy of first-line chemotherapy in colorectal cancer (CRC), yet the stress-responsive signaling mechanisms that enable tumor cells to adapt to platinum-induced...
Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease [0.03%]
常染色体显性多囊肾病中肌成纤维细胞特异性自噬驱动囊肿生长
Abeda Jamadar,Viji Remadevi,Meekha M Varghese et al.
Abeda Jamadar et al.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst expansion, fibrosis and inflammation, leading to kidney failure. Myofibroblasts (MFs) often accumulate around cysts and...
P2X4 receptor limits adverse cardiac remodeling following ischemia-reperfusion through regulation of autophagy in cardiac fibroblasts [0.03%]
缺血再灌注诱导的心室重构中P2X4通过心房纤维母细胞自噬调控限制不良心室重构发生的发展作用及机制研究
Ana Valeria Vinhais da Silva,Juliette Strella,Simon Chesseron et al.
Ana Valeria Vinhais da Silva et al.
Background: Pathological ventricular remodeling is an adverse tissue response following acute myocardial infarction (AMI), characterized by an exaggerated fibrosis leading to tissue disorganization and chronic heart failu...