TRIM47 catalyzes MAVS SUMOylation to safeguard chronic viral infections and tissue inflammation [0.03%]
TRIM47通过催化MAVS的SUMO化来守护慢性病毒感染和组织炎症
Wenting Lu,Junji Xing,Junying Wang et al.
Wenting Lu et al.
Background: Chronic tissue inflammation causes progressive tissue damage, organ dysfunction, and increased susceptibility to inflammatory diseases. Viral infections are major drivers of this process, but the molecular mec...
Harnessing tumor-associated exosomal aminopeptidase N as a dual-function tool for monitoring and tackling chemoresistance in gastric cancer [0.03%]
利用肿瘤相关外泌体氨基肽酶N作为监测和治疗胃癌化疗耐药性的双重功能工具
Wangyu Cai,Zheru Ma,Wen Xie et al.
Wangyu Cai et al.
Chemoresistance remains a major obstacle to effective treatment in gastric cancer (GC), with a notable scarcity of clinically applicable biomarkers and therapeutic targets. In this study, we employed an integrated proteomic approach analyzi...
Correction: Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress [0.03%]
订正：奥氮平通过抑制前额叶皮层活动-去甲肾上腺素释放来缓解慢性压力下CLOCK增强的癌症干细胞特性
Jinxin Lu,Xiaoyu Zhang,Keyu Su et al.
Jinxin Lu et al.
IGF2R: a new player in the IGF2 loop sustaining adrenocortical carcinogenesis [0.03%]
IGF2R在维持肾上腺皮质癌发生发展中的IGF2回路中的新作用
Emma Nozza,Emanuela Esposito,Sonia Di Bari et al.
Emma Nozza et al.
Background: Most of adrenocortical carcinomas (ACC) are characterized by IGF2 overexpression; therefore, several studies have focused on its two oncogenic effectors, the tyrosine-kinase receptors IGF1R and IR. However, th...
Trophoblast cells rewire the epigenetic landscape of vascular smooth muscle cells to modulate plasticity: a regulatory axis disrupted in intrauterine growth restriction [0.03%]
滋养细胞重塑血管平滑肌细胞表观遗传景观以调节其转分化能力：胎儿宫内生长受限中功能失调的调控轴心
Poulomi Sarkar,Rupasri Ain
Poulomi Sarkar
Background: Uterine spiral artery remodelling (SAR) is a fundamental developmental process that facilitates optimal placental perfusion and supports fetal growth. Central to SAR is the phenotypic transformation of vascula...
Free mitochondrial transfer enhances bone regeneration through cathepsin H mediated cysteine cycle [0.03%]
基于半胱氨酸代谢的自由线粒体移植促进骨再生作用及机制研究
Jiayong Diao,Qixuan He,Quanzhen Liu et al.
Jiayong Diao et al.
Background: Mitochondria, as crucial organelles in eukaryotic cells, are deeply involved in cellular energy metabolism and biogenesis. Currently, mitochondria have been found to transfer between cells and regulate a range...
A ROS/HIF-1α/JMY signaling axis drives radiation-induced migration and invasion of neural progenitor cells [0.03%]
ROS/HIF-1α/JMY信号轴驱动放射诱导的神经前体细胞迁移和侵袭
Oriane Bergiers,Hayet Bensalah-Pigeon,Oscar Gitton-Quent et al.
Oriane Bergiers et al.
Background: Neural progenitor cell (NPC) migration is essential for proper cortical development, and its disruption contributes to severe brain malformations such as lissencephaly, polymicrogyria, and microcephaly. Althou...
Oncogenic PIK3CA reprograms glutamine metabolism to drive bladder cancer progression [0.03%]
致癌性PIK3CA重新编程谷氨酰胺代谢以促进膀胱癌进展
Karthik Reddy Kami Reddy,Vasanta Putluri,Danthasinghe Waduge Badrajee Piyarathna et al.
Karthik Reddy Kami Reddy et al.
Background: Genomic analysis has revealed that approximately 40% of bladder cancer (BLCA) tumors harbor alterations in the PI3K/AKT pathway, with PIK3CA mutations occurring in 15-25% of cases. PIK3CA, which encodes the ca...
AI-driven multi-omics deciphering of extrachromosomal circular DNA rescues hidden targets in colorectal cancer [0.03%]
人工智能驱动的表观基因多组学破解染色体外环状DNA揭示隐藏的结直肠癌靶点
Lili Zhang,Jian Cui,Tianhan Sun et al.
Lili Zhang et al.
Background: Extrachromosomal circular DNA (eccDNA) is an emerging tumor biomarker notable for its tumor-specific amplification and contribution to genomic heterogeneity. However, the substantial heterogeneity of eccDNAs p...
Parkinson's disease as a multi-axis systems disorder: integrating molecular pathology and circuit-level therapeutics [0.03%]
帕金森病作为多轴系统障碍：分子病理和电路水平治疗的整合
Duc-Hiep Bach,Thanh Liem Nguyen
Duc-Hiep Bach
Parkinson's disease (PD) has generated extensive mechanistic insight, yet nearly all candidate disease-modifying therapies have failed in clinical trials. Antibodies targeting α-synuclein, mitochondrial antioxidants, lysosomal intervention...