Dynamic m6A epitranscriptomic remodeling coordinates host transcriptional reprogramming during MPXV infection [0.03%]
Mpox病毒感染期间动态的m6A表转录组重塑协调宿主转录重编程
Ruixia Tang,Jindi Huang,Wenhai Yu et al.
Ruixia Tang et al.
Background: The global emergence of monkeypox virus (MPXV) highlights the urgent need for a deeper understanding of host-pathogen interactions. Although transcriptional responses to MPXV infection have been characterized,...
SPP1-positive macrophages drive trastuzumab resistance in HER2-positive breast cancer [0.03%]
HER2阳性乳腺癌中SPP1阳性巨噬细胞驱动赫赛汀耐药性
Donghui Wang,Guodong Li,Yajie Lu et al.
Donghui Wang et al.
Trastuzumab-based HER2-targeted therapy remains the cornerstone treatment for HER2-positive breast cancer. However, its clinical efficacy is significantly modulated by the tumor microenvironment (TME). Our single-cell sequencing analysis of...
Glycolysis drives vascular hyperpermeability in acute lung injury via lactate-GPR81 axis in endothelial cells [0.03%]
糖酵解通过乳酸-GPR81轴驱动内皮细胞急性肺损伤中的血管高通透性
Kun Chen,Kerui Fan,Jiao Wang et al.
Kun Chen et al.
A growing body of evidence suggests that enhanced glycolysis profoundly reprograms inflammatory response in acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS), but the underlying mechanisms largely remain unclear. Lactate i...
Notch receptors in breast cancer: context-dependent roles and therapeutic targeting [0.03%]
诺特赫受体在乳腺癌中的作用及治疗靶向性研究
Mei Wang,Yue Mi,Qinong Ye
Mei Wang
Breast cancer (BC) development is influenced by multifactorial mechanisms. Despite significant advancements in early diagnostic techniques and comprehensive therapeutic approaches, BC continues to pose a substantial threat to women's health...
Dual-recognizing antibodies targeting CEACAMs in the tumor microenvironment: towards more precise targeting [0.03%]
靶向肿瘤微环境中的CEACAMs的双重识别抗体：更精确的靶向治疗
Jiayi Ye,Yijun Zhao,Shuyang Mao et al.
Jiayi Ye et al.
The tumor microenvironment (TME) is a dynamic and constantly evolving milieu surrounding cancer cells, comprising numerous components that influence tumor growth. The Carcinoembryonic Antigen-Related Cell Adhesion Molecule (CEACAM) family h...
The IGF2-ERK-Fos axis drives a Müller cell glial-mesenchymal transition-like response to disrupt retinal homeostasis in early myopia [0.03%]
IGF2-ERK-Fos轴驱动Müller胶质细胞类似间充质转化的反应以干扰早期近视的眼内稳态
Jiaojiao Feng,Xiaoqi Gong,Yibo Han et al.
Jiaojiao Feng et al.
Myopia is increasingly recognized as a complex pathology involving retinal remodeling, yet the cellular mechanisms linking early visual stress to this process remain unclear. This study investigated whether Müller glial (MG) cells undergo ...
Platelet homeostasis and heterogeneity in inflammation and sepsis: mechanisms, biological effects, and clinical potential [0.03%]
炎症和脓毒症中的血小板稳态与异质性：机制、生物学效应及临床潜力
Yiyun Pan,Wenling Zhao,Beibei Yu et al.
Yiyun Pan et al.
Sepsis is a life-threatening syndrome resulting from a dysregulated host immune response to infection and is frequently accompanied by coagulation abnormalities and multiple organ dysfunction. As central regulators at the intersection of he...
IqgD is a Rac1-interacting IQGAP required for efficient growth of Dictyostelium discoideum on bacterial lawns [0.03%]
IQGD是Dictyostelium discoideum高效生长所需的与Rac1相互作用的IQGAP家族蛋白
Anja Čizmar,Darija Putar,Marija Šimić et al.
Anja Čizmar et al.
Background: Phagocytosis of surface-bound microbes is essential for host defence and environmental feeding, yet the mechanism by which macrophages remove surface-bound particles has only recently been described. This proc...
Targeting astrocyte-mediated neurotoxicity induced by ALS/FTD-associated RNA binding proteins [0.03%]
靶向ALS/FTD相关RNA结合蛋白诱导的星形胶质细胞介导的神经毒性
Myungjin Jo,Seyeon Kim,Junghwa Woo et al.
Myungjin Jo et al.
Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders characterized by reactive astrocytes that contribute to neuronal injury through TAR DNA-binding protein 43 ...
TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies [0.03%]
神经退行性疾病和急性神经系统损伤中的TREM2：机制及靶向治疗
Haixia Wang,Ruiming Wen,Emily Parker et al.
Haixia Wang et al.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a critical myeloid receptor expressed on the surface of central nervous system microglia, capable of integrating signals from lipids, damage-associated molecular patterns, and abno...