Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling [0.03%]
内皮细胞-间质相互作用通过Notch信号驱动人成骨细胞的成骨分化
Perepletchikova Daria,Kuchur Polina,Basovich Liubov et al.
Perepletchikova Daria et al.
Background: Angiogenesis and osteogenesis are closely interrelated. The interaction between endothelial and bone-forming cells, such as osteoblasts, is crucial for normal bone development and repair. Juxtacrine and paracr...
Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects [0.03%]
CD8＋T细胞固有的STING调控自身代谢重编程和记忆以发挥抗肿瘤效应
Qiuli Xu,Xin Hua,Bingbing Li et al.
Qiuli Xu et al.
Background: Our team has previously found that the stimulator of interferon genes (STING) plays a more significant anti-tumor role in host immune cells than in tumor cells. Although STING is necessary for CD8 + T cells to...
Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome [0.03%]
Cullin-RING连接酶BioE3揭示了分子胶诱导的新底物以及内源性Cereblon泛素组的重新布线
Laura Merino-Cacho,Orhi Barroso-Gomila,Mónica Pozo-Rodríguez et al.
Laura Merino-Cacho et al.
Background: The specificity of the ubiquitination process is mediated by the E3 ligases. Discriminating genuine substrates of E3s from mere interacting proteins is one of the major challenges in the field. We previously d...
Silja Wessler,Nicole Meisner-Kober
Silja Wessler
Cells from organisms across all kingdoms of life continuously release a diverse repertoire of extracellular vesicles (EVs) into their extracellular environment as an elegant strategy for both, cellular homeostasis and communication with oth...
Functions of the Muscleblind-like protein family and their role in disease [0.03%]
肌肉盲基因家族的功能及其在疾病中的作用
Hui Zhou,Jiachi Xu,Liusheng Pan
Hui Zhou
Conserved proteins are characterized by their functions remaining nearly constant throughout evolutionary history, both vertically through time and horizontally across species. In this review, we focus on a class of conserved proteins known...
The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway [0.03%]
与癌症关联的纤维细胞和凋亡癌细胞相互作用通过WISP-1-整联蛋白ανβ3-STAT1信号通路抑制肺癌细胞生长
Shinyoung Kim,Kyungwon Yang,Kiyoon Kim et al.
Shinyoung Kim et al.
Background: Cell death within the tumor microenvironment (TME) plays a crucial role in controlling cancer by influencing the balance of tumor-specific immunity. Cancer-associated fibroblasts (CAFs) significantly contribut...
REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling [0.03%]
肿瘤周围腺泡细胞分泌的REG3A通过激活EGFR信号促进胰腺导管腺癌的发展
Xiaojing Ren,Yunfei Teng,Kunxin Xie et al.
Xiaojing Ren et al.
Background: Regenerating family member 3A (REG3A) is involved in the development of multiple malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). However, any role of REG3A in PDAC remains controversial du...
COVID-19 patient serum-derived extracellular vesicles deliver miR-20b-5p induces neutrophil extracellular traps [0.03%]
COVID-19患者血清来源的外泌体递送miR-20b-5p诱导中性粒细胞外陷阱形成
Yao Liao,Yuheng Liu,Dinghao Li et al.
Yao Liao et al.
Background: Severe cases of COVID-19 are characterized by an excessive presence of neutrophils. Neutrophil extracellular traps (NETs), released by activated neutrophils due to SARS-CoV-2 infection, contribute to lung epit...
Adenosine A2A receptor-mediated interactions between Th1+ T cells and the choroid plexus epithelium via IFN-γ signalling control T-Cell infiltration in experimental autoimmune encephalomyelitis [0.03%]
腺苷A2A受体通过IFN-γ信号传导介导Th1+T细胞与脉络丛上皮之间的相互作用以控制实验性自身免疫性脑脊髓炎中的T细胞浸润
Chenxing Qi,Yuwen Yang,Ping Tang et al.
Chenxing Qi et al.
Background: Adenosine A2A receptor (A2AR) antagonists have been consistently demonstrated to protect against multiple sclerosis (MS) pathology, but A2AR knockout (A2AR-/-) mice exhibit exacerbated immune injury, raising c...
Microglial depletion decreases Müller cell maturation and inner retinal vascular density [0.03%]
小胶质细胞耗竭降低穆勒细胞的成熟度和内视网膜血管密度
Nathaniel Rowthorn-Apel,Naveen Vridhachalam,Kip M Connor et al.
Nathaniel Rowthorn-Apel et al.
Background: The neuroretinal vascular system is comprised of three interconnected layers. The initial superficial vascular plexus formation is guided by astrocytes around birth in mice. The formation of the deep and inter...