Ten-eleven translocation-2-mediated macrophage activation promotes liver regeneration [0.03%]
十一体位移-2介导的巨噬细胞活化促进肝脏再生
Yiyuan Chen,Lijun Meng,Nan Xu et al.
Yiyuan Chen et al.
Background: The remarkable regenerative capacity of the liver enables recovery after radical Hepatocellular carcinoma (HCC) resection. After resection, macrophages secrete interleukin 6 and hepatocyte growth factors to pr...
NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain [0.03%]
NLRP3通过依赖ROS的NET形成在小鼠脑中加重EAE严重程度
Da Jeong Byun,Jaeho Lee,Kyungryung Ko et al.
Da Jeong Byun et al.
Background: Neutrophil extracellular trap (NET) has been implicated in the pathology of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, the specific contributions of NLRP3, a NET-asso...
Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity [0.03%]
人CXCL10的天然羧基末端截短削弱了糖胺聚糖结合，CXCR3A信号传导和淋巴细胞化学趋向性，同时保留了抗血管生成活性
Luna Dillemans,Karen Yu,Alexandra De Zutter et al.
Luna Dillemans et al.
Background: Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupl...
Ferritin-mediated neutrophil extracellular traps formation and cytokine storm via macrophage scavenger receptor in sepsis-associated lung injury [0.03%]
铁蛋白通过巨噬斑清除受体介导中性粒细胞胞外陷阱的形成及脓毒血症相关肺损伤中的细胞因子风暴
Hao Zhang,Dan Wu,Yanghanzhao Wang et al.
Hao Zhang et al.
Background: Sepsis is a severe systemic inflammatory disorder manifested by a dysregulated immune response to infection and multi-organ failure. Numerous studies have shown that elevated ferritin levels exist as an essent...
Design of stable circular permutants of the GroEL chaperone apical domain [0.03%]
GroEL分子伴侣顶区的稳定圆形置换的设计
Tatiana N Melnik,Maria A Majorina,Daria E Vorobeva et al.
Tatiana N Melnik et al.
Enhancing protein stability holds paramount significance in biotechnology, therapeutics, and the food industry. Circular permutations offer a distinctive avenue for manipulating protein stability while keeping intra-protein interactions int...
T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration [0.03%]
遗传性视网膜变性的光感受器细胞死亡中T型电压门控通道，Na+/Ca2+交换子和钙蛋白酶-2的作用
Jie Yan,Lan Wang,Qian-Lu Yang et al.
Jie Yan et al.
Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology has been linked to an excessive activation of cyclic nucleotide-gated channels (...
Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells [0.03%]
大电导机械敏感通道促进施万细胞机械拉伸诱导的糖酵解和氧化代谢的上调作用
Fangzhen Shan,Nannan Zhang,Xiaoying Yao et al.
Fangzhen Shan et al.
Background: Physical exercise directly stretching the peripheral nerve promotes nerve regeneration; however, its action mechanism remains elusive. Our present study aimed to investigate the effects of mechanosensitive cha...
Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets [0.03%]
线粒体动态变化与结直肠癌生物学：机制及潜在靶点
Zihong Wu,Chong Xiao,Jing Long et al.
Zihong Wu et al.
Colorectal cancer (CRC) is a significant public health concern, and its development is associated with mitochondrial dysfunction. Mitochondria can adapt to the high metabolic demands of cancer cells owing to their plasticity and dynamic nat...
Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy [0.03%]
未折叠蛋白反应在治疗抵抗中新兴机制：从化疗到免疫治疗
Jiang He,You Zhou,Lunquan Sun
Jiang He
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR). As an adaptive cellular response to hostile microenvironments, such as hypoxia, nutrien...
Arginyltransferase 1 modulates p62-driven autophagy via mTORC1/AMPk signaling [0.03%]
精氨酰转移酶1通过mTORC1/AMPk信号调节p62驱动的自噬
Laura V Bonnet,Anabela Palandri,Jesica B Flores-Martin et al.
Laura V Bonnet et al.
Background: Arginyltransferase (Ate1) orchestrates posttranslational protein arginylation, a pivotal regulator of cellular proteolytic processes. In eukaryotic cells, two interconnected systems-the ubiquitin proteasome sy...