Neural peer pressure: intercellular dynamics and emergent phenotypes in the mosaic Rett syndrome brain [0.03%]
神经压力：镶嵌式雷特综合征脑的细胞间动态和表型涌现
Jarno Koetsier,Chris P Reutelingsperger,Leopold M G Curfs et al.
Jarno Koetsier et al.
During female embryogenesis, each cell randomly inactivates either the maternal or paternal X chromosome, creating a natural mix, or mosaic, of cells with a different active X chromosome. In X-linked neurological disorders such as Rett synd...
The SHH/GLI target Netrin-1 supports self-renewal in medulloblastoma tumor cells [0.03%]
SHH/GLI靶点Netrin-1可支持髓母细胞瘤肿瘤干细胞的自我更新
P Falcón,E Fernández-Caniulén,J M Zúñiga-Hernández et al.
P Falcón et al.
Deregulation of the Sonic Hedgehog (SHH)/GLI signaling pathway has been strongly implicated in carcinogenesis, particularly in brain and skin tumors, through mutations affecting various pathway components. Given its central role in tumor de...
Small extracellular vesicle-mediated transfer of HPV16 transcripts from Ca Ski cells increases proliferation of HPV-negative recipient cancer cells [0.03%]
HPV16阳性的Ca Ski细胞分泌的小细胞外囊泡介导的转录组转移可促进HPV阴性受体癌细胞增殖
Sergen Arslan,Alexandre Barbaud,Jason Bernauer et al.
Sergen Arslan et al.
Background: Tumor-produced extracellular vesicles (EVs) are key players in cancer progression by transferring their bioactive cargo (nucleic acids, lipids, proteins) to target cells leading to increase their proliferation...
Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets [0.03%]
神经递质与癌症：如何通过受体信号传导和翻译后修饰调节肿瘤的进展并提供新的治疗靶点
Xuanyin Ding,Hele Liu,Weiran Zhang et al.
Xuanyin Ding et al.
Recent studies highlight the multifaceted roles of neurotransmitters in tumor immunomodulation, offering novel avenues for increasing therapeutic efficacy. These signaling molecules are classified into cholinergic agents, monoamines, amino ...
Post-translational modifications of mitochondrion-related proteins: integrative orchestrators of cell fate networks in cardiovascular disease [0.03%]
线粒体相关蛋白的翻译后修饰：整合调节心血管疾病中心理网络的关键因素
Lei Liu,Saiteng Wu,Lei Zhang et al.
Lei Liu et al.
Cardiovascular disease remains the leading cause of global mortality, with mitochondrial dysfunction playing a central pathogenic role. Post-translational modifications act as fundamental regulators of mitochondrial quality control. Yet, ho...
Liver sinusoidal endothelial cell fenestrations in metabolic liver disease: from molecular mechanisms to therapeutic perspectives [0.03%]
代谢性肝病的肝窦内皮细胞窗孔：从分子机制到治疗前景
Akram S Al-Mughalles,Junhu Ma,Hong Ma et al.
Akram S Al-Mughalles et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), constitute major causes of hepatic morbidity worldwide. Central to the pathophy...
The cGAS-STING pathway contributes to cisplatin-induced skeletal muscle atrophy through altered proteostasis and myogenic signaling [0.03%]
cGAS-STING途径通过改变蛋白质稳态和肌细胞信号通路促进顺铂诱导的骨骼肌萎缩
Xiaoguang Liu,Miaomiao Xu,Huan Wang et al.
Xiaoguang Liu et al.
Background: Cisplatin chemotherapy is widely used for cancer treatment but frequently induces skeletal muscle atrophy, which compromises physical function and patient outcomes. The molecular mechanisms underlying this pro...
From energy metabolic homeostasis to immune remodeling: the role and therapeutic potential of STING signaling in the tumor microenvironment [0.03%]
从能量代谢稳态到免疫重塑：STING信号通路在肿瘤微环境中的作用及治疗潜力
Kui Zhao,Xiaohua Wen,Lanyu Zheng et al.
Kui Zhao et al.
The stimulator of interferon genes (STING) pathway is a core regulatory axis of innate immunity. By sensing cytoplasmic DNA, it activates the transcription of type I interferons and pro-inflammatory cytokines, playing a pivotal role in medi...
Liver cancer derived high core fucosylation sEV elict malignancy by activating PI3K/AKT signaling pathway [0.03%]
肝癌来源核心高岩藻糖化的外泌体通过激活PI3K/AKT信号通路诱导恶性进展
Zhuo Li,Na Zhang,Wei Zhang et al.
Zhuo Li et al.
Small extracellular vesicles (sEV) play a key role in liver cancer (LC) by supporting cancer cell survival, local invasion, and distant metastasis. Although sEV surfaces are known to be richly glycosylated, how these glycans influence sEV f...
Tunneling nanotubes: a new dimension of intercellular communication and recent progress [0.03%]
隧道状纳米管：细胞间通讯的新维度及其近期进展
Xinyu Dong,Yan Xuan,Muning Wang et al.
Xinyu Dong et al.
Communication between cells can occur over long distances through the diffusion of soluble mediators and the delivery of extracellular vesicles (EVs), and over short distances through contact-dependent junctional structures formed between a...